List of works - Josep Bassaganya-Riera

Abscisic Acid Regulates Inflammation via Ligand-binding Domain-independent Activation of Peroxisome Proliferator-activated Receptor γ ⬇️

scientific article published on November 18, 2010

Abscisic Acid: A Novel Nutraceutical for Glycemic Control

scientific article

Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall

scientific article

Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration

scientific article

Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR γ axis

scientific article

Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells

scientific article published on 06 November 2019

Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation

scientific article published on April 2009

Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease

scientific article

Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice ⬇️

scientific article published on May 31, 2011

Agent-Based Modeling and High Performance Computing

Agents and networks to model the dynamic interactions of intracellular transport

scientific article

An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease

scientific article published on 15 November 2016

Analysis of pomegranate seed oil for the presence of jacaric acid

Animal models of enteroaggregativeEscherichia coliinfection ⬇️

scientific article published on 02 May 2013

Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets

scientific article

Bistability analyses of CD4+ T follicular helper and regulatory cells during Helicobacter pylori infection

scientific article

CD4+ T-cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae-induced colitis in pigs

scientific article

CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD.

scientific article

Catalpic acid decreases abdominal fat deposition, improves glucose homeostasis and upregulates PPAR alpha expression in adipose tissue

scientific article

Challenges in Personalized Nutrition and Health

article

Computational Modeling

article

Computational modeling of heterogeneity and function of CD4+ T cells

scientific article

Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2

scientific article

Conjugated Linoleic Acid Ameliorates Viral Infectivity in a Pig Model of Virally Induced Immunosuppression ⬇️

scientific article published on October 1, 2003

Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma

scientific article

Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease ⬇️

scientific article published on April 20, 2012

Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization

scientific article published on 6 March 2017

Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease

scientific article published on 28 October 2010

Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets

scientific article

Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPARγ-dependent mechanism ⬇️

scientific article published on September 17, 2012

Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease

scientific article published on September 2010

Dietary modulation of inflammation-induced colorectal cancer through PPARγ.

scientific article published on 22 April 2009

Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome

scientific article published on 20 February 2008

Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ

scientific article

Dysregulated intracellular signaling and inflammatory gene expression during initial disease onset in Duchenne muscular dystrophy

scientific article published on June 2009

ENISI SDE: A New Web-Based Tool for Modeling Stochastic Processes

scientific article published in March 2015

ENISI multiscale modeling of mucosal immune responses driven by high performance computing

article

ENteric Immunity SImulator: a tool for in silico study of gastroenteric infections

scientific article published in September 2012

Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea

scientific article published in February 2010

Emerging significance of NLRs in inflammatory bowel disease

scientific article

Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide ⬇️

scientific article published on March 8, 2013

Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease

scientific article published on 26 May 2016

Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1

scientific article published on 25 October 2019

Expression of PPAR γ in intestinal epithelial cells is dispensable for the prevention of colitis by dietary abscisic acid ⬇️

scientific article published on October 1, 2012

From Big Data Analytics and Network Inference to Systems Modeling

Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension ⬇️

scientific article published on October 13, 2010

Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling ⬇️

scientific article published on March 5, 2011

Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice

scientific article

Goals in Nutrition Science 2015-2020

scientific article

Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice

scientific article

Helicobacter pylori Infection in a Pig Model Is Dominated by Th1 and Cytotoxic CD8+T Cell Responses ⬇️

scientific article published on July 29, 2013

Helicobacter pylori colonization ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism

scientific article

High-resolution computational modeling of immune responses in the gut.

scientific article published in June 2019

Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention

scientific article published on August 2009

Immunoinformatics Cyberinfrastructure for Modeling and Analytics

Immunomodulatory properties of conjugated linoleic acid

scientific article

Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease

scientific article

Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria

scientific article (publication date: 2012)

Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells

scientific article published in January 2004

Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection

scientific article published on 21 February 2017

Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes

scientific article

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

scientific article published on 6 July 2007

Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease

scientific article published on April 2010

Modeling Exercises

Modeling new immunoregulatory therapeutics as antimicrobial alternatives for treating Clostridium difficile infection

scientific article

Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa

scientific article

Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection

scientific article

Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection

scientific article

Modeling the Role of Peroxisome Proliferator-Activated Receptor γ and MicroRNA-146 in Mucosal Immune Responses to Clostridium difficile ⬇️

scientific article published on October 11, 2012

Modeling-Enabled Characterization of Novel NLRX1 Ligands

scientific article

Modeling-Enabled Systems Nutritional Immunology

scientific article

Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis

scientific article

Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection

scientific article

Modulation of inflammation and immunity by dietary conjugated linoleic acid

scientific article published on 15 May 2015

Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics

scientific article published on 30 May 2010

Multiscale Modeling

Multiscale modeling of mucosal immune responses

scientific article published on 25 August 2015

Mutations to essential orphan response regulator HP1043 of Helicobacter pylori result in growth-stage regulatory defects

scientific article

NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host-Gut Microbiota Interactions during Inflammatory Bowel Disease

scientific article published on 26 February 2018

NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-κB signaling

scientific article published on 20 April 2016

Novel Screening Tool for Stroke Using Artificial Neural Network

scientific article published on 24 April 2017

Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection

scientific article published on 22 April 2014

Nutritional protective mechanisms against gut inflammation ⬇️

scientific article published on March 27, 2013

Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid

scientific article

Ordinary Differential Equations (ODEs) Based Modeling

PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation

scientific article published on 06 May 2009

PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections

scientific article published on August 2010

Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis

scientific article

Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition

scientific article published on 18 October 2006

Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands

scientific article

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex

scientific article published on 8 May 2015

Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis

scientific article

Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori

scientific article

Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection

scientific article

Preventive and Prophylactic Mechanisms of Action of Pomegranate Bioactive Constituents ⬇️

scientific article published on April 30, 2013

Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis

scientific article published on 21 February 2012

Putting the pieces of the puzzle together - a series of hypotheses on the etiology and pathogenesis of type 1 diabetes

scientific article

Response to letter to the Editor – Implementation of integrative approaches to improve the design of Crohn's disease clinical trials ⬇️

scientific article published on October 31, 2012

Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection

scientific article published on September 2015

Soluble Fibers and Resistant Starch Ameliorate Disease Activity in Interleukin-10–Deficient Mice with Inflammatory Bowel Disease ⬇️

scientific article published on May 11, 2011

Solving Immunology?

scientific article published on 13 December 2016

Stopping anti-TNF agents in patients with Crohn's disease in remission: is it a feasible long-term strategy?

scientific article published on April 2014

Supervised Learning with the Artificial Neural Networks Algorithm for Modeling Immune Cell Differentiation

scholarly article published 2015

Supervised learning methods in modeling of CD4+ T cell heterogeneity

scientific article published on 4 September 2015

Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor γ expression ⬇️

scientific article published on February 4, 2011

Systemic effects of white adipose tissue dysregulation and obesity-related inflammation

scientific article published on 07 October 2010

Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection

scientific article published on 31 July 2015

Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity

scientific article

Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection

scientific article

Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis

scientific article

T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD ⬇️

scientific article published on December 15, 2010

The Role of Peroxisome Proliferator-Activated Receptor γ in Immune Responses to Enteroaggregative Escherichia coli Infection ⬇️

scientific article published on February 28, 2013

The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis

scientific article

The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease

scientific article

Translating nutritional immunology into drug development for inflammatory bowel disease

scientific article published on 26 September 2016

Translational research and efficacy of biologics in Crohn's disease: a cautionary tale

scientific article published on February 2014

Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists ⬇️

scientific article published on December 28, 2010

Virtual Screening as a Technique for PPAR Modulator Discovery

scientific article published on 2 September 2009

Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea

scientific article

List of works by Josep Bassaganya-Riera

Abscisic Acid Regulates Inflammation via Ligand-binding Domain-independent Activation of Peroxisome Proliferator-activated Receptor γ ⬇️

Abscisic Acid: A Novel Nutraceutical for Glycemic Control

Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall

Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration

Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR γ axis

Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells

Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation

Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease

Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice ⬇️

Agent-Based Modeling and High Performance Computing

Agents and networks to model the dynamic interactions of intracellular transport

An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease

Analysis of pomegranate seed oil for the presence of jacaric acid

Animal models of enteroaggregativeEscherichia coliinfection ⬇️

Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets

Bistability analyses of CD4+ T follicular helper and regulatory cells during Helicobacter pylori infection

CD4+ T-cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae-induced colitis in pigs

CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD.

Catalpic acid decreases abdominal fat deposition, improves glucose homeostasis and upregulates PPAR alpha expression in adipose tissue

Challenges in Personalized Nutrition and Health

Computational Modeling

Computational modeling of heterogeneity and function of CD4+ T cells

Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2

Conjugated Linoleic Acid Ameliorates Viral Infectivity in a Pig Model of Virally Induced Immunosuppression ⬇️

Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma

Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease ⬇️

Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization

Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease

Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets

Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPARγ-dependent mechanism ⬇️

Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease

Dietary modulation of inflammation-induced colorectal cancer through PPARγ.

Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome

Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ

Dysregulated intracellular signaling and inflammatory gene expression during initial disease onset in Duchenne muscular dystrophy

ENISI SDE: A New Web-Based Tool for Modeling Stochastic Processes

ENISI multiscale modeling of mucosal immune responses driven by high performance computing

ENteric Immunity SImulator: a tool for in silico study of gastroenteric infections

Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea

Emerging significance of NLRs in inflammatory bowel disease

Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide ⬇️

Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease

Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1

Expression of PPAR γ in intestinal epithelial cells is dispensable for the prevention of colitis by dietary abscisic acid ⬇️

From Big Data Analytics and Network Inference to Systems Modeling

Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension ⬇️

Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling ⬇️

Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice

Goals in Nutrition Science 2015-2020

Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice

Helicobacter pylori Infection in a Pig Model Is Dominated by Th1 and Cytotoxic CD8+T Cell Responses ⬇️

Helicobacter pylori colonization ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism

High-resolution computational modeling of immune responses in the gut.

Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention

Immunoinformatics Cyberinfrastructure for Modeling and Analytics

Immunomodulatory properties of conjugated linoleic acid

Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease

Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria

Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells

Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection

Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease

Modeling Exercises

Modeling new immunoregulatory therapeutics as antimicrobial alternatives for treating Clostridium difficile infection

Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa

Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection

Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection

Modeling the Role of Peroxisome Proliferator-Activated Receptor γ and MicroRNA-146 in Mucosal Immune Responses to Clostridium difficile ⬇️

Modeling-Enabled Characterization of Novel NLRX1 Ligands

Modeling-Enabled Systems Nutritional Immunology

Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis

Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection

Modulation of inflammation and immunity by dietary conjugated linoleic acid

Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics

Multiscale Modeling

Multiscale modeling of mucosal immune responses

Mutations to essential orphan response regulator HP1043 of Helicobacter pylori result in growth-stage regulatory defects

NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host-Gut Microbiota Interactions during Inflammatory Bowel Disease