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List of works by Nicholas R J Gascoigne

A THEMIS:SHP1 complex promotes T-cell survival

scientific article

A high content imaging flow cytometry approach to study mitochondria in T cells: MitoTracker Green FM dye concentration optimization

scientific article published on 30 November 2017

A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness

scientific article (publication date: May 2005)

Allelic Exclusion of the TCR α-Chain Is an Active Process Requiring TCR-Mediated Signaling and c-Cbl ⬇️

scientific article published on May 1, 2003

Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire

scientific article

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

scientific article published on 27 July 2006

Autoimmune responses and inflammation in type 2 diabetes

scientific article published on 23 March 2020

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

scientific article

CD8+ T cells have commitment issues

scientific article published in August 2018

CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.

scientific article published on December 2011

Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition

scientific article

Co-receptors and recognition of self at the immunological synapse

scientific article published on January 2010

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.

scientific article published on 12 August 2013

Correction: In Silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness

scientific article

Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection

scientific article published on 16 January 2014

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

scientific article published on 21 February 2019

Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.

scientific article published on 3 July 2018

Distinct footprints of TCR engagement with highly homologous ligands

scientific article published in June 2004

Do T cells need endogenous peptides for activation?

scientific article published in November 2008

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development ⬇️

scientific article published on March 4, 2013

In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness

scientific article

Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse

scientific article published in April 2002

Initiation of TCR phosphorylation and signal transduction

scientific article published on 7 December 2011

Lck bound to coreceptor is less active than free Lck

scientific article published on 22 June 2020

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor

scientific article

Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma

scientific article published on 3 December 2016

Molecular interactions at the T cell-antigen-presenting cell interface

scientific article published on February 2004

Monomeric TCRs drive T cell antigen recognition

scientific article published on 16 April 2018

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry

scientific article published on 30 July 2009

Negative Selection Assay Based on Stimulation of T Cell Receptor Transgenic Thymocytes with Peptide-MHC Tetramers ⬇️

scientific article published on August 10, 2012

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

scientific article published on 13 July 2018

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

scientific article published on 26 June 2005

Photobleaching-corrected FRET efficiency imaging of live cells

scientific article

Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation ⬇️

scientific article published on December 6, 2011

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function

scientific article

Protein kinase Cη, an emerging player in T-cell biology ⬇️

scientific article published on March 1, 2012

SHP1-ing thymic selection

scientific article published in September 2016

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

scientific article published on 25 May 2020

Signaling in thymic selection

scientific article

Spatiotemporal patterning during T cell activation is highly diverse

scientific article

Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells

scientific article published on 17 October 2006

Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics

scientific article published on 14 February 2003

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component ⬇️

scientific article published on December 28, 2010

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state

scientific article

T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis

scientific article published on 13 January 2020

T-cell differentiation: MHC class I's sweet tooth lost on maturity

scientific article

TCR Signal Strength and T Cell Development

scientific article

TCR affinity and negative regulation limit autoimmunity

article

TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants

scientific article published on 30 August 2017

THEMIS: a critical TCR signal regulator for ligand discrimination

scientific article

Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities

scientific article published on 23 June 2016

The Role of Protein Kinase Cη in T Cell Biology ⬇️

scientific article published on June 27, 2012

The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation

scientific article published on June 2008

The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex

scientific article published in August 2002

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation

scientific article

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling

scientific article

Themis regulates metabolic signaling and effector functions in CD4+ T cells by controlling NFAT nuclear translocation

scientific article published on 11 November 2020

Themis sets the signal threshold for positive and negative selection in T-cell development

scientific article

Themis-associated phosphatase activity controls signaling in T cell development

article published in the Proceedings of the National Academy of Sciences of the United States of America

Thymic Origins of T Cell Receptor Alloreactivity

scientific article published on 20 January 2017

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

scientific article published in November 2006

Thymocyte stimulation by anti-TCR-β, but not by anti-TCR-α, leads to induction of developmental transcription program

scientific article published in May 2005

Tolerance lies in the timing

scientific article published in Nature

Too fast to die.

scientific article

Using live FRET imaging to reveal early protein-protein interactions during T cell activation

scientific article published in August 2004

Virus-specific T lymphocytes home to the skin during natural dengue infection

scientific article published on March 2015

Visualizing intermolecular interactions in T cells

scientific article published on January 2009

Vive la peptide différence!

scientific article

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