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List of works by Aleš Cvekl

A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens

scientific article

A distal enhancer that directs Otx2 expression in the retinal pigment epithelium and neuroretina

scientific article published on 19 November 2019

Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.

scientific article published in November 2004

Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases

scientific article published on April 2004

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers

Cataract- and lens-specific upregulation of ARK receptor tyrosine kinase in Emory mouse cataract.

scientific article

Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype

scientific journal article

Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth

scientific journal article

Chromatin features, RNA polymerase II and the comparative expression of lens genes encoding crystallins, transcription factors, and autophagy mediators

scientific article published on 28 August 2015

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

scientific journal article

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

scientific article published on June 2016

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis

scientific journal article

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

scientific article

DACH1 inhibits transforming growth factor-beta signaling through binding Smad4

scientific article

DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth

scientific article

Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens

scientific article

Dual requirement for Pax6 in retinal progenitor cells

scientific article published on 12 November 2008

Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions

scientific article

Evolutionary Origins of Pax6 Control of Crystallin Genes

scientific article published in August 2017

Expression of the alpha4 integrin subunit gene promoter is modulated by the transcription factor Pax-6 in corneal epithelial cells

scientific article published on June 2004

Focus on Molecules: Brg1: A range of functions during eye development ⬇️

scientific article published on September 24, 2011

Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation

scientific article

Functional interactions between alternatively spliced forms of Pax6 in crystallin gene regulation and in haploinsufficiency

scientific article published on 12 March 2004

Functional properties of natural human PAX6 and PAX6(5a) mutants

scientific article

Gene regulation by PAX6: structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204.

scientific article

Gene sharing and evolution.

scientific article

Genetic and epigenetic mechanisms of gene regulation during lens development

scientific article

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

scientific article published on 12 September 2013

Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation

scientific journal article

Identification of differentially expressed genes in mouse Pax6 heterozygous lenses.

scientific article

Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays

scientific article

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development

scientific article

Identification of novel Gata3 distal enhancers active in mouse embryonic lens

scientific article published on 10 November 2018

Identification of pax6-dependent gene regulatory networks in the mouse lens

scientific article

Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid

scientific article

Large Maf Transcription Factors: Cousins of AP-1 Proteins and Important Regulators of Cellular Differentiation

scientific article

Lens Biology and Biochemistry

scientific article published on 04 June 2015

Lens Development and Crystallin Gene Expression

scientific article published on 12 June 2015

Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis

scientific article

Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat

scientific article (publication date: 2014)

PAX6: 25th anniversary and more to learn

scientific article published on 25 April 2016

Palm is expressed in both developing and adult mouse lens and retina

scientific article

Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204 ⬇️

scientific article published on March 14, 2013

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers

scientific article published on 09 September 2016

Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain

scientific article

Perturbing the Ubiquitin Pathway Reveals How Mitosis Is Hijacked to Denucleate and Regulate Cell Proliferation and Differentiation In Vivo ⬇️

scientific article published on October 20, 2010

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

scientific article published on 2 May 2017

Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus

scientific article published on 7 December 2018

Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling

scientific article published on 30 December 2015

Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens

scientific article

Retinoic acid signaling in mammalian eye development

scientific article published on 07 May 2009

Rybp, a polycomb complex-associated protein, is required for mouse eye development

scientific article

Signaling and Gene Regulatory Networks in Mammalian Lens Development

scientific article published on 31 August 2017

Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals

scientific article published on 6 July 2016

Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation

Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice

scientific article published in June 2017

Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells

scientific article

Spectrum and Range of Oxidative Stress Responses of Human Lens Epithelial Cells to H2O2 Insult ⬇️

scientific article published on May 1, 2003

Structure of the retinal determination protein Dachshund reveals a DNA binding motif

scientific article

The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops ⬇️

scientific article published on October 13, 2011

Tissue-specific regulation of the mouse alphaA-crystallin gene in lens via recruitment of Pax6 and c-Maf to its promoter

scientific article

Transcription Elongation Regulator 1 Is a Co-integrator of the Cell Fate Determination Factor Dachshund Homolog 1 ⬇️

scientific article published on October 18, 2010

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

scientific article published on 29 June 2018

Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates

scientific article

Transcriptional regulation of mouse alphaB- and gammaF-crystallin genes in lens: opposite promoter-specific interactions between Pax6 and large Maf transcription factors

scientific article

Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract

scientific article published on 20 November 2015

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