List of works - Willem van Eden

A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis

scientific article published in April 2010

APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients

scientific article published on 30 May 2016

Activated peritoneal cavity B-1a cells possess regulatory B cell properties

scientific article

Anergic T cells actively suppress T cell responses via the antigen-presenting cell

article

Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions

scientific article published on 01 May 1999

Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation

scientific article published on January 2014

Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice

scientific article

Biologics and postbiologics: novel immunotherapeutics for the induction and maintenance of remission

scientific article published on 20 January 2009

Bystander activation of irrelevant CD4+ T cells following antigen-specific vaccination occurs in the presence and absence of adjuvant

scientific article

CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis

scientific article

Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis

scientific article

Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants

scientific article published on March 2010

Cellular host transcriptional responses to influenza A virus in chicken tracheal organ cultures differ from responses in in vivo infected trachea

scientific article

Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice

scientific article published on March 2002

DEC205+ Dendritic Cell-Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis

scientific article published on 10 April 2015

Diet and the anti-inflammatory effect of heat shock proteins

scientific article published on January 2015

Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity

scientific article published on January 2013

Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules ⬇️

scientific article published on May 1, 1994

Dynamics of APC recruitment at the site of injection following injection of vaccine adjuvants

scientific article published on 17 February 2017

Early host responses to avian influenza A virus are prolonged and enhanced at transcriptional level depending on maturation of the immune system

scientific article published on 10 April 2010

Effector and regulatory T cells derived from the same T cell clone differ in MHC class II-peptide multimer binding

scientific article published in December 2004

Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants

scientific article (publication date: April 2009)

Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chicken

scientific article published on August 2013

Goals in Nutrition Science 2015-2020

scientific article

Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis

scientific article

Heat shock proteins and their immunomodulatory role in inflammatory arthritis

scientific article

Heat shock proteins are no DAMPs, rather 'DAMPERs' ⬇️

scientific article published on July 25, 2011

Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions ⬇️

scientific article published on July 16, 2012

Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy

scientific article

Heat-shock proteins induce T-cell regulation of chronic inflammation

scientific article

Highly diverse TCR δ chain repertoire in bovine tissues due to the use of up to four D segments per δ chain

Hsp70 expression and induction as a readout for detection of immune modulatory components in food

scientific article

Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats

scientific article published in August 2013

IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis

scientific article

Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134.

scientific article published on 10 October 2007

Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity

scientific article

Identification of new populations of chicken natural killer (NK) cells

scientific article

Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein

article

Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes

scientific article published on 01 January 2018

Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity.

scientific article

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design.

scientific article

Immunomodulatory effects of antigen-pulsed macrophages in a murine model of allergic asthma

scientific article published in August 2002

Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity

scientific article

Immunoregulation of autoimmune diseases

scientific article

In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide

scientific article published on 24 June 2015

Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope

scientific article

Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

scientific article

Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells

scientific article published on 9 May 2007

Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection

scientific article

Massive, sustained gammadelta T cell migration from the bovine skin in vivo

scientific article published on 18 January 2007

Matrix metalloproteinases as targets for the immune system during experimental arthritis

scientific article published in April 2004

Mycobacterial 70kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis

scientific article published in 2006

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

scientific article published on 16 July 2010

Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes

scientific article published in July 2008

PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3(+) T-cells in vitro

scientific article published on 14 March 2013

PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity

scientific article

Peritoneal cavity B-1a cells promote peripheral CD4+ T-cell activation

scientific article published on 3 July 2013

Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4(+) T helper type 1 subset differentiation

scientific article published in April 2012

Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function

scientific article

Protective and therapeutic effect of triptolide in EAE explained by induction of major stress protein HSP70.

scientific article published on 14 October 2009

Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance

scientific article

Reduced immune reaction prevents immunopathology after challenge with avian influenza virus: a transcriptomics analysis of adjuvanted vaccines

scientific article published on 14 July 2010

Regulatory T cell frequencies and phenotypes following anti-viral vaccination

scientific article

Routing dependent immune responses after experimental R848-adjuvated vaccination

scientific article published on 3 February 2018

Stress proteins as inducers and targets of regulatory T cells in arthritis

scientific article

Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration

scientific article

Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro

scientific article published on 10 November 2015

T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins

scientific article published on 26 October 2017

The Enigma of Heat Shock Proteins in Immune Tolerance

scientific article published on 21 November 2017

The Immunology of Cellular Stress Proteins ⬇️

scientific article published on June 18, 2013

The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins

scientific article published on 30 November 2017

The Tricky Balancing Act of using Heat Shock Proteins for Cross-Presentation

scientific article published on 10 May 2012

The anti-inflammatory mechanisms of Hsp70

scientific article published on 4 May 2012

The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity

scientific article published in November 2002

The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d

scientific article

The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle

scientific article published on 16 June 2009

Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress

scientific article

Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases

scientific article published on 20 August 2013

Vaccination during pregnancy: safe or not?

scientific article

XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator

scientific article published on May 2008

[Life in a clean environment: risky if we have to believe the 'hygiene hypothesis'].

scientific article

List of works by Willem van Eden

A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis

APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients

Activated peritoneal cavity B-1a cells possess regulatory B cell properties

Anergic T cells actively suppress T cell responses via the antigen-presenting cell

Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions

Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation

Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice

Biologics and postbiologics: novel immunotherapeutics for the induction and maintenance of remission

Bystander activation of irrelevant CD4+ T cells following antigen-specific vaccination occurs in the presence and absence of adjuvant

CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis

Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis

Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants

Cellular host transcriptional responses to influenza A virus in chicken tracheal organ cultures differ from responses in in vivo infected trachea

Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice

DEC205+ Dendritic Cell-Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis

Diet and the anti-inflammatory effect of heat shock proteins

Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity

Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules ⬇️

Dynamics of APC recruitment at the site of injection following injection of vaccine adjuvants

Early host responses to avian influenza A virus are prolonged and enhanced at transcriptional level depending on maturation of the immune system

Effector and regulatory T cells derived from the same T cell clone differ in MHC class II-peptide multimer binding

Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants

Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chicken

Goals in Nutrition Science 2015-2020

Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis

Heat shock proteins and their immunomodulatory role in inflammatory arthritis

Heat shock proteins are no DAMPs, rather 'DAMPERs' ⬇️

Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions ⬇️

Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy

Heat-shock proteins induce T-cell regulation of chronic inflammation

Highly diverse TCR δ chain repertoire in bovine tissues due to the use of up to four D segments per δ chain

Hsp70 expression and induction as a readout for detection of immune modulatory components in food

Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats

IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis

Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134.

Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity

Identification of new populations of chicken natural killer (NK) cells

Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein

Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes

Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity.

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design.

Immunomodulatory effects of antigen-pulsed macrophages in a murine model of allergic asthma

Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity

Immunoregulation of autoimmune diseases

In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide

Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope

Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells

Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection

Massive, sustained gammadelta T cell migration from the bovine skin in vivo

Matrix metalloproteinases as targets for the immune system during experimental arthritis

Mycobacterial 70kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes

PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3(+) T-cells in vitro

PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity

Peritoneal cavity B-1a cells promote peripheral CD4+ T-cell activation

Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4(+) T helper type 1 subset differentiation

Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function

Protective and therapeutic effect of triptolide in EAE explained by induction of major stress protein HSP70.

Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance

Reduced immune reaction prevents immunopathology after challenge with avian influenza virus: a transcriptomics analysis of adjuvanted vaccines

Regulatory T cell frequencies and phenotypes following anti-viral vaccination

Routing dependent immune responses after experimental R848-adjuvated vaccination

Stress proteins as inducers and targets of regulatory T cells in arthritis

Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration

Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro

T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins

The Enigma of Heat Shock Proteins in Immune Tolerance

The Immunology of Cellular Stress Proteins ⬇️

The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins

The Tricky Balancing Act of using Heat Shock Proteins for Cross-Presentation

The anti-inflammatory mechanisms of Hsp70

The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity

The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d

The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle

Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress

Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases

Vaccination during pregnancy: safe or not?