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List of works by Steven A Porcelli

"Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes".

scientific article published on 20 October 2015

"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report

scientific article published on 2 May 2017

A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity

scientific article

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

scientific article

A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production

scientific article

A critical role for CD8 T cells in a nonhuman primate model of tuberculosis

scientific article

A glycan shield for bacterial sphingolipids

scientific article published on July 2008

A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids

scientific article

A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

scientific article published on 4 September 2011

A review of the PD-1/PD-L1 checkpoint in bladder cancer: From mediator of immune escape to target for treatment

scientific article published on 2 November 2016

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

scientific article

A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens

scientific article published on 09 January 2014

A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan

scientific article

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

scientific article published on 08 October 2009

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

scientific article published on December 2009

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

scientific article published on 4 March 2008

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

scientific article

AnN-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and β2-Microglobulin

scientific article published in Journal of Biological Chemistry

Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis

scientific article published on 7 March 2007

Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response

scientific article

Autoimmune response to transthyretin in juvenile idiopathic arthritis

scientific article published on 25 February 2016

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response ⬇️

scientific article published on July 11, 2013

Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance ⬇️

scientific article published on March 29, 2013

Balancing safety and immunogenicity in live-attenuated mycobacterial vaccines for use in humans at risk for HIV: response to misleading comments in Ranganathan et al. "recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell respon

scientific article published on 26 March 2010

Bird genes give new insights into the origins of lipid antigen presentation

scientific article

CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver.

scientific article

CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

scientific article published on 25 May 2009

CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens

scientific article published on 25 March 2013

CD1d and natural killer T cells in immunity to Mycobacterium tuberculosis

scientific article published on January 2013

CD1d-Restricted Natural Killer T Cells: Roles in Tumor Immunosurveillance and Tolerance

CD1d-restricted T cell activation by nonlipidic small molecules

scholarly article

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation

scientific article

Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect

scientific article published on 5 May 2017

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect

scientific article

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.

scientific article

Combined natural killer T-cell based immunotherapy eradicates established tumors in mice

scientific article published on August 2007

Control of NKT cell differentiation by tissue-specific microenvironments

scientific article published in December 2003

Correction: Expression Patterns of Bovine CD1 In Vivo and Assessment of the Specificities of the Anti-Bovine CD1 Antibodies

scientific article published on 5 June 2015

Current efforts and future prospects in the development of live mycobacteria as vaccines

scientific article

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice

scientific journal article

Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia

scientific article

Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes

scientific article published on 9 October 2003

Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells

scientific article

Diverse CD1d-restricted reactivity patterns of human T cells bearing “invariant” AV24BV11 TCR

scientific article published on 01 December 1998

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity

scientific article published on 9 March 2018

Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against Mycobacterium tuberculosis determined by PCR array

scientific article published on 26 November 2008

Efficient activation of Valpha14 invariant NKT cells by foreign lipid antigen is associated with concurrent dendritic cell-specific self recognition

scientific article published in March 2007

Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes

scientific article

Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

scientific article published in August 2007

Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors

scientific article published in April 2009

Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

scientific article published in Nature

Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosis

scientific article published on October 2014

Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine

scientific article published on 01 May 2019

Expansion and hyperactivity of CD1d-restricted NKT cells during the progression of systemic lupus erythematosus in (New Zealand Black x New Zealand White)F1 mice

scientific article published on July 2005

Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies

scientific article published on 27 March 2015

Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex

scientific article published on April 2002

Fine tuning by human CD1e of lipid-specific immune responses

scientific article

Gene deletions in Mycobacterium bovis BCG stimulate increased CD8+ T cell responses

scientific article

Generation of IL-3-Secreting CD4+ T Cells by Microbial Challenge at Skin and Mucosal Barriers

scientific article published on 16 May 2019

Glycolipid activators of invariant NKT cells as vaccine adjuvants

scientific article

Glycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T Cells

scientific article

Human CD1-restricted T cell recognition of lipids from pollens

scientific article

Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells ⬇️

scientific article published on February 4, 2013

Human NKT cells express granulysin and exhibit antimycobacterial activity

scientific article (publication date: 15 March 2003)

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

scientific article

Identification of Mycobacterial Ribosomal Proteins as Targets for CD4 T Cells That Enhance Protective Immunity in Tuberculosis

scholarly article published by Alessandro Sette in 2018

Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells

scientific article published on 23 January 2017

Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis

scientific article published in August 2003

Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells

scientific article

In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG

scientific article

In vitro derivation of macrophage from guinea pig bone marrow with human M-CSF.

scientific article published on 16 January 2013

Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin

scientific article published on August 2009

Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens

scientific article published on July 2002

Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH.

scientific article published on 22 March 2018

Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani

scientific article

Intracellular pathways of CD1 antigen presentation

scientific article

Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation

scientific article published in September 2007

Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration

scientific article published on 15 April 2009

Isolation and In vivo Transfer of Antigen Presenting Cells.

scientific article published on 05 October 2014

Isolation of intact RNA from murine CD4+ T cells after intracellular cytokine staining and fluorescence-activated cell sorting

scientific article published on 17 February 2018

Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation

scientific article published on June 2009

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

scientific article

Lipid and glycolipid antigens of CD1d-restricted natural killer T cells

scientific article

Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation

scientific article

Lysine Auxotrophy Combined with Deletion of the SecA2 Gene Results in a Safe and Highly Immunogenic Candidate Live Attenuated Vaccine for Tuberculosis ⬇️

scientific article published on January 10, 2011

Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer

scholarly article

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by V 14i NKT Cells

scientific article

Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides

scientific article

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

scientific article published on 28 January 2008

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

scientific article

Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae

scientific article published in Nature Communications

Multiple immuno-regulatory defects in type-1 diabetes

scientific article

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

scientific journal article

Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response

scientific article

Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis

scientific article

Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.

scientific article

Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule

scientific journal article

Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells

scientific article

Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells

scientific article

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production

scientific article

NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells

scientific article published in August 2003

New CD1d agonists: synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

scientific article

Optimizing NKT cell ligands as vaccine adjuvants

scientific article published on January 2014

Pillars article: analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCR α chain. J. Exp. Med. 1993. 178: 1-16.

scientific article published in August 2014

Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d

scientific article published on 5 April 2007

Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis

scientific article published in July 2004

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

scientific article

Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries

scientific article

Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989.

scientific article published in April 2010

Recognition of lipids from pollens by CD1-restricted T cells

scientific article published on February 2007

Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

scientific article

Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques

scientific article published on 30 July 2014

Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice

scientific article

Role of lipid trimming and CD1 groove size in cellular antigen presentation

scientific article published on 22 June 2006

Saposin C is required for lipid presentation by human CD1b

article

Similarities and differences between selective and nonselective BAFF blockade in murine SLE

scientific article

Species Specific Differences of CD1d Oligomer Loading In Vitro

scientific article published on 24 November 2015

Structural Basis for the Recognition of C20:2-αGalCer by the Invariant Natural Killer T Cell Receptor-like Antibody L363

scientific article

Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids

scientific article

Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes

scientific article published on 19 November 2018

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.

scientific article published on 15 August 2016

Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry

scientific article

Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000.

scientific article published on 22 April 2010

Synthesis and biological activity of alpha-glucosyl C24:0 and C20:2 ceramides

scientific article published on June 2010

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.

scientific article published on 18 May 2009

Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.

scientific article published in December 2005

Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

scientific article

Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents

scientific article

T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection

scientific article

Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines

scientific article

The CD1b structure: antigen presentation adapts to a high-fat diet

scientific article

The CD1d natural killer T-cell antigen presentation pathway is highly conserved between humans and rhesus macaques

scientific article published on 6 February 2003

The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition

scholarly article

The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis

scientific article published on 18 April 2016

The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d

scientific article

The diverse functions of CD1d-restricted NKT cells and their potential for immunotherapy

scientific article

The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens.

scientific article published on March 2005

Tuberculosis: unsealing the apoptotic envelope

scientific article published on October 2008

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages

scientific article published on December 2007

V 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

scientific article

Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formation

scientific article published on February 2004

pH-dependent interdomain tethers of CD1b regulate its antigen capture

scientific article published on June 2008

Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents

scientific article

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