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List of works by Philip Anton van der Merwe

2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48

scientific article

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

scientific article

A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8+ T cell responses in vivo

scientific article published in April 2009

A subtle role for CD2 in T cell antigen recognition

scientific article published on November 1999

Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.

scientific article

An induced rebinding model of antigen discrimination

scientific article

Analysis of the structure and interactions of CD2.

scientific article published on November 1993

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation

scientific article

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling

scientific article published on 14 November 2011

Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses

scientific article

CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics

scientific article

CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes

scientific article

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

scientific article (publication date: March 2003)

Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor

scientific article

Comparison of CD22 binding to native CD45 and synthetic oligosaccharide

scientific article

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope

scientific article

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

scientific article published on 23 October 2015

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

scientific article

Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex

scientific article published on July 1999

Design of a calcium-binding protein with desired structure in a cell adhesion molecule

scientific article published in February 2005

Determination of the lifetime and force dependence of interactions of single bonds between surface-attached CD2 and CD48 adhesion molecules

scientific article published on December 1996

Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48

scientific article

Entropically driven MHC class I recognition by human inhibitory receptor leukocyte Ig-like receptor B1 (LILRB1/ILT2/CD85j).

scientific article

Formation and function of the immunological synapse

scientific article published in June 2002

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors

scientific article (publication date: December 2000)

How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?

scientific article

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G

scientific article

Immunology: how do T cells recognize antigen?

scientific article

Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.

scientific article published on 15 December 2006

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

scientific article

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands

scientific article

Late Arrival: Recruiting Coreceptors to the T Cell Receptor Complex ⬇️

scientific article published on January 28, 2011

Lck and the nature of the T cell receptor trigger ⬇️

scientific article published on December 27, 2010

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation

scientific article published on 2 June 2006

Ligand dimensions are important in controlling NK-cell responses

scientific article

Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity

scientific article published on 22 February 2008

Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity ⬇️

scientific article published in Journal of Biological Chemistry

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces

scientific article published on 20 March 2012

Mechanisms for T cell receptor triggering

scientific article

Molecular interactions mediating T cell antigen recognition

scientific article

Molecular mechanisms involved in T cell receptor triggering

scientific article published on 7 June 2007

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response

scientific article published on April 2016

Mutant prolactin receptor and familial hyperprolactinemia

scientific article

Mutational analysis of the epitopes recognized by anti-(rat CD2) and anti-(rat CD48) monoclonal antibodies

scientific article published on February 1995

Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse

scientific article

Non-catalytic tyrosine-phosphorylated receptors

scientific article

Parasitic infestation in Cape Town children. A random study of 101 patients

scientific article

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation

scientific article published on 23 July 2009

Phenotypic models of T cell activation

scientific article published in September 2014

Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity

scientific article published in March 2008

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

scientific article

Siglecs: A family of sialic-acid binding lectins ⬇️

scientific article published on February 1, 1998

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly

scientific article

Stochasticity and spatial heterogeneity in T-cell activation

scientific article published on April 2007

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

scientific article

Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms

scientific article

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism

scientific article

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

scientific article

T cell cross-reactivity and conformational changes during TCR engagement

scientific article

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

scientific article

Taking T cells beyond the diffraction limit

scientific article published in January 2010

The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction

scientific article

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

scientific article published on 13 October 2016

The dependence of the association rate of surface-attached adhesion molecules CD2 and CD48 on separation distance

scientific article published in February 1997

The interaction properties of costimulatory molecules revisited.

scientific article published in August 2002

The kinetic-segregation model: TCR triggering and beyond

scientific article published on August 2006

The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor

scientific article published on 11 April 2013

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

scientific article published on 7 May 2007

The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48.

scientific article

The nature of molecular recognition by T cells

scientific article

The role of charged residues mediating low affinity protein–protein recognition at the cell surface by CD2 ⬇️

scientific article published on May 12, 1998

The structure and ligand interactions of CD2: implications for T-cell function

scientific article published on April 1996

Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins

scientific article

Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice

scientific article published in December 1996

Tumour necrosis factor

scientific article published on October 1988

Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins

scientific article

Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane? ⬇️

scientific article published on February 23, 2012

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