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List of works by Samuel H. Wilson

"Action-at-a-distance" mutagenesis. 8-oxo-7, 8-dihydro-2'-deoxyguanosine causes base substitution errors at neighboring template sites when copied by DNA polymerase beta.

scientific article published on May 1999

( R )-β,γ-Fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase β

scientific article

1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase beta

scientific article published on 01 February 2002

A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β

scientific article published on 14 March 2019

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

scientific article published on 01 April 2019

A minor groove binding track in reverse transcriptase

scientific article published on 01 March 1997

A novel DNA polymerase activity found in association with intracisternal A-type particles.

scientific article

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases

scientific article published on 14 August 2009

A role for p53 in base excision repair.

scientific article

A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta

scientific article

A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase beta ternary complex

scientific article published on November 2005

A type IB topoisomerase with DNA repair activities

scientific article published on 15 May 2001

A vinyl polymer with purine residues deficient in base pairing inhibits murine leukemia virus replication ⬇️

scientific article published on March 15, 1978

AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate.

scientific article

AP endonuclease-independent DNA base excision repair in human cells

scientific article

ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.

scientific article published on 9 February 2007

Activities and mechanism of DNA polymerase beta

scientific article (publication date: 2006)

Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.

scientific article

Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.

scientific article

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

scientific article

Anomalous electrophoretic migration of oligodeoxynucleotides with terminal -OH groups: applications for DNA exonuclease characterization

scientific article published on 01 February 1983

Antibodies from patients and mice with autoimmune diseases react with recombinant hnRNP core protein A1

scientific article published on 01 February 1988

Applications of quantum mechanical/molecular mechanical methods to the chemical insertion step of DNA and RNA polymerization

scientific article

Apurinic/apyrimidinic (AP) site recognition by the 5′-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1) ⬇️

scientific article published on December 2, 2010

Assignments of 1H, 15N, and 13C resonances for the backbone and side chains of the N-terminal domain of DNA polymerase beta. Determination of the secondary structure and tertiary contacts

scientific article published on 01 August 1994

Base excision repair and design of small molecule inhibitors of human DNA polymerase β.

scientific article published on 16 September 2010

Base excision repair defects invoke hypersensitivity to PARP inhibition

scientific article

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens ⬇️

scientific article published on September 15, 2003

Base excision repair in nucleosomes lacking histone tails.

scientific article published in February 2005

Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

scientific article published on 25 July 2003

Base excision repair of tandem modifications in a methylated CpG dinucleotide.

scientific article

Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove

scientific article published on 01 July 1999

Binary complex crystal structure of DNA polymerase   reveals multiple conformations of the templating 8-oxoguanine lesion

scientific article

Binary system for selective photoaffinity labeling of base excision repair DNA polymerases

scientific article

Biomedical research leaders: report on needs, opportunities, difficulties, education and training, and evaluation.

scientific article

Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts

scientific article

Capturing snapshots of APE1 processing DNA damage.

scientific article

Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA

scientific article published on 25 July 2009

Characterization of the tryptophan fluorescence and hydrodynamic properties of rat DNA polymerase beta

scientific article published on 01 November 1994

Chromosomal location of the human gene for DNA polymerase beta.

scientific article

Cloning and characterization of a novel member of the human ATF/CREB family: ATF2 deletion, a potential regulator of the human DNA polymerase beta promoter.

scientific article

Coincidentally, this first issue marks the 50th anniversary of the seminal discovery of the excision-repair of damaged DNA. Preface.

scientific article

Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts.

scientific article published on 15 April 2016

Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity.

scientific article

Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.

scientific article published on September 2017

Complementation of aprataxin deficiency by base excision repair enzymes.

scientific article

Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion.

scientific article published on 11 August 2009

Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta

scientific article

Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly

scientific article

Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism, ⬇️

scientific article published on September 16, 1997

Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism

scientific article

Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

scientific article

Cultured cell systems and methods for neurobiology.

scientific article published in January 1974

Cutting-edge Perspectives in Genomic Maintenance III: Preface

scientific article published on 31 May 2016

Cutting-edge Perspectives in Genomic Maintenance. Preface

scientific article published on 16 June 2015

Cutting-edge perspectives in genomic maintenance IV

scientific article published on 24 June 2017

Cutting-edge perspectives in genomic maintenance V

scientific article published on 25 September 2018

DNA Polymerase   Substrate Specificity: SIDE CHAIN MODULATION OF THE"A-RULE"

scientific article

DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts ⬇️

scientific article published on August 18, 2010

DNA base excision repair: a mechanism of trinucleotide repeat expansion.

scientific article published on 27 January 2012

DNA damage response of cloned DNA beta-polymerase promoter is blocked in mutant cell lines deficient in protein kinase A ⬇️

scientific article published on November 11, 1992

DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion

scientific article

DNA lesion bypass polymerases open up.

scientific article

DNA polymerase III of mouse myeloma. Partial purification and characterization ⬇️

scientific article published on March 11, 1975

DNA polymerase and simian virus 40 infection of resting monkey cells: induction of aphidicolin resistant α-polymerase ⬇️

scientific article published on December 10, 1983

DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis.

scientific article published on 5 July 2001

DNA polymerase beta and DNA synthesis in Xenopus oocytes and in a nuclear extract

scientific article published on October 16, 1992

DNA polymerase beta and PARP activities in base excision repair in living cells

scientific article published on 12 September 2009

DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair

scientific article published on 22 November 2004

DNA polymerase beta and mammalian base excision repair.

scientific article

DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract.

scientific article published in January 1995

DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state

scientific article published on 28 December 2007

DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding.

scientific article

DNA polymerase beta-dependent long patch base excision repair in living cells

scientific article

DNA polymerase beta.

scientific article

DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts

scientific article (publication date: 6 May 2005)

DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair

scientific article published on 7 July 2005

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

scientific article

DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine.

scientific article

DNA polymerase β contains a functional nuclear localization signal at its N-terminus

scientific article

DNA polymerase β gap-filling translesion DNA synthesis

scientific article

DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

scientific article published on 04 December 2019

DNA polymerase β uses its lyase domain in a processive search for DNA damage

scientific article

DNA polymerase β-dependent cell survival independent of XRCC1 expression

scientific article

DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria

scientific article published on 28 October 2017

DNA polymerases lose their grip.

scientific article published in November 2001

DNA polymerases on the move

scientific article published on 01 February 1998

DNA scanning by base excision repair enzymes and implications for pathway coordination

scientific article published on 25 August 2018

DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase

scientific article

DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts.

scientific article

Damage sensor role of UV-DDB during base excision repair

scientific article published on 22 July 2019

Deregulation of DNA polymerase ? by sense and antisense RNA expression in mouse 3T3 cells alters cell growth ⬇️

scientific article published on July 1, 1990

Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta.

scientific article

Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells

scientific article published on 01 March 1998

Different structural states in oligonucleosomes are required for early versus late steps of base excision repair.

scientific article published on 18 June 2007

Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta

scientific article published on 9 February 2007

Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.

scientific article

Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences.

scientific article published on February 1997

Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines

scientific article

Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta.

scientific article

Editorial

Editorial

Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.

scientific article published on 19 October 2012

Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.

scientific article

Energy analysis of chemistry for correct insertion by DNA polymerase beta

scholarly article

Enzymes for modifying and labeling DNA and RNA

scientific article published on 01 January 1987

Erratum: Requirement of mammalian DNA polymerase-β in base-excision repair

scientific article published in Nature

Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism

scientific article published on 01 June 2019

Evidence for abasic site sugar phosphate-mediated cytotoxicity in alkylating agent treated Saccharomyces cerevisiae

scientific article

Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction

scientific article published on 01 July 1996

Exploring the role of large conformational changes in the fidelity of DNA polymerase beta

scientific article published on January 2008

Expression and purification of the HIV-1 reverse transcriptase using the baculovirus expression vector system.

scientific article published on August 1993

Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme

scientific article

Expression of polypeptides of human immunodeficiency virus-1 reverse transcriptase in Escherichia coli.

scientific article

FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells

scientific article

FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

scientific article

First US-EU DNA repair meeting: endogenous stress, National Conference Center, VA, USA, 14-18 October 2003

scientific article published on 01 May 2004

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase

scientific article published on July 2008

Gastrointestinal hyperplasia with altered expression of DNA polymerase beta

scientific article published on 5 August 2009

Genetic relatedness of human DNA polymerase beta and terminal deoxynucleotidyltransferase

scientific article published on 01 January 1987

HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system

scientific article (publication date: December 1999)

HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates.

scientific article

HMGB1 is a cofactor in mammalian base excision repair

scientific article

HMGB1: roles in base excision repair and related function.

scientific article

HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts

scientific journal article

Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues

scientific article

Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate

scientific article published in August 2006

Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites.

scientific article published on 15 December 2016

High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase.

scientific article published in March 2004

Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.

scientific article

Histone H3 Lysine 56 Acetylation Enhances AP Endonuclease 1-Mediated Repair of AP Sites in Nucleosome Core Particles

scientific article published on 16 August 2019

Human DNA Polymerase-beta Promoter: Phorbol Ester Activation Is Mediated through the cAMP Response Element and cAMP-Response-Element-Binding Protein

scientific article published on 01 November 1997

Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

scientific article published on 01 June 1998

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

scientific article

Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity

scientific article

Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts

scientific article

Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions

scientific article published on January 2003

Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency

scientific article published on 20 November 2006

Identification and properties of the catalytic domain of mammalian DNA polymerase beta

scientific article published on 01 August 1990

Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro ⬇️

scientific article published on October 13, 1998

Identification of a nuclear protein binding element within the rat brain protein kinase C gamma promoter that is related to the developmental control of this gene.

scientific article published in July 1993

Identification of novel mRNA isoforms for human DNA polymerase beta

scientific article

Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies

scientific article

Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.

scientific article published on 15 July 2004

Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine.

scientific article published on 22 September 2016

Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

scientific article published in January 1998

Improved conditions for activity gel analysis of DNA polymerase catalytic polypeptides

scientific article published on 01 December 1983

In situ analysis of repair processes for oxidative DNA damage in mammalian cells.

scientific article

In vitro Assay to Measure DNA Polymerase β Nucleotide Insertion Coupled with the DNA Ligation Reaction during Base Excision Repair.

scientific article published on June 2017

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta ⬇️

scholarly article

Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-Inhibited Mouse Fibroblasts ⬇️

scientific article published on January 13, 2012

Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.

scientific article

Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts

scientific article

Inhibition of cell-free globin synthesis by polydeoxythymidylate ⬇️

scientific article published on February 4, 1973

Inhibitors of HIV-1 reverse transcriptase and fidelity of in vitro DNA replication

scientific article published on January 1, 1992

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening

scientific article published on 31 March 2016

Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.

scientific article published on 24 June 2013

Interaction between DNA Polymerase β and BRCA1

scientific article

Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition

scientific article published on 22 August 2008

Interactions between DNA polymerase beta and the major covalent adduct of the carcinogen (+)-anti-benzo[a]pyrene diol epoxide with DNA at a primer-template junction.

scientific article

Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: Evidence for multiple RNA binding domains and salt-dependent binding mode transitions ⬇️

scientific article published on March 19, 1991

Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells

scientific article

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

scientific article

Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage.

scientific article

Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.

scientific article published in September 2005

Kinetic analysis of Sp1-mediated transcriptional activation of a TATA-containing promoter.

scientific article published on February 2000

Kinetic analysis of Sp1-mediated transcriptional activation of the human DNA polymerase beta promoter

scientific article published on 01 September 2000

Kinetic analysis of template.primer interactions with recombinant forms of HIV-1 reverse transcriptase

scientific article published on 01 September 1993

Levels and size complexity of DNA polymerase beta mRNA in rat regenerating liver and other organs.

scientific article published on July 1989

Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus

scientific article

Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding ⬇️

scientific article published on November 5, 1991

Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.

scientific article published on 29 May 2003

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

scientific article published on 26 December 2001

Lysines in the lyase active site of DNA polymerase β destabilize non-specific DNA binding, facilitating searching and DNA gap recognition

scientific article published on 09 July 2020

Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects

scientific article published on 3 November 2006

Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

scientific article published on April 2006

Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair.

scientific article published on 28 May 2015

Mammalian DNA beta-polymerase in base excision repair of alkylation damage.

scientific article

Mammalian DNA polymerase beta: characterization of a 16-kDa transdomain fragment containing the nucleic acid-binding activities of the native enzyme

scientific article published on October 27, 1992

Mammalian base excision repair and DNA polymerase beta ⬇️

scientific article published on 01 June 1998

Mammalian beta-polymerase promoter: large-scale purification and properties of ATF/CREB palindrome binding protein from bovine testes.

scientific article

Mammalian beta-polymerase promoter: phosphorylation of ATF/CRE-binding protein and regulation of DNA binding.

scientific article published on June 1991

Mammalian heterogeneous ribonucleoprotein A1 and its constituent domains. Nucleic acid interaction, structural stability and self-association

scientific article published on 01 February 1993

Mapping Functional Substrate-Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs

scientific article published on 21 June 2018

Mapping of the gene for DNA polymerase beta to mouse chromosome 8

scientific article published on 01 January 1990

Mapping of the interaction interface of DNA polymerase beta with XRCC1.

scientific article

Measurement of the rate and velocity of movement by single heart cells in culture

scientific article published on 01 August 1973

Metal-induced DNA translocation leads to DNA polymerase conformational activation ⬇️

scientific article published on December 14, 2011

Micro-irradiation tools to visualize base excision repair and single-strand break repair

scientific article published on 5 May 2015

Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates

scientific article published on 01 September 2000

Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity.

scientific article

Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts

scientific article published on 27 March 2020

Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta

scientific article

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

scientific article published on 31 July 2017

Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion

scientific article

Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β

scientific article published on 18 March 2019

Multiple forms of DNA polymerase in mouse myeloma.

scientific article published on February 1974

Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break ⬇️

scientific article published on September 9, 2010

Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice

scientific article published on 23 July 2008

Mutagenic conformation of 8-oxo-7,8-dihydro-2′-dGTP in the confines of a DNA polymerase active site

scientific article

Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress

scientific article

NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells

scientific article

Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells.

scientific article published on 22 April 2008

New assay technique for reactions that produce radioactive gases ⬇️

scientific article published on October 1, 1971

New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis.

scientific article published on 30 April 2015

Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS

scientific article

Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate

scientific article published in August 2005

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

scientific article published on 22 April 2007

Observing a DNA Polymerase Choose Right from Wrong

scientific article

On the measurement of tritium in DNA and its applications to the assay of DNA polymerase activity

scientific article published on 01 January 1976

Oncornavirus expression in human x mouse hybrid cells segregating mouse chromosomes.

scientific article published on May 1974

Optimal and variant metal-ion routes in DNA polymerase β's conformational pathways

scientific article

Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair

scientific article

Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

scientific article published on 16 January 2020

Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.

scientific article published on 14 March 2016

Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

scientific article published on 09 January 2017

PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.

scientific article published on 31 August 2009

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1.

scientific article published on 7 November 2017

Passing the baton in base excision repair

scientific article published on 01 March 2000

Patterns of albumin and general protein synthesis in rat liver as revealed by gel electrophoresis

scientific article published on 01 May 1972

Personalized exposure assessment: promising approaches for human environmental health research

scientific article

Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms

scientific article published on 23 November 2012

Phorbol ester abrogates up-regulation of DNA polymerase beta by DNA-alkylating agents in Chinese hamster ovary cells.

scientific article published on July 1995

Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members

scientific article

Physical studies of tyrosine and tryptophan residues in mammalian A1 heterogeneous nuclear ribonucleoprotein. Support for a segmented structure

scientific article published on 01 September 1991

Physiology of rat-liver polysomes. The stability of messenger ribonucleic acid and ribosomes.

scientific article

Pol β associated complex and base excision repair factors in mouse fibroblasts.

scientific article

Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate

scientific article published in Nature Communications

Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.

scientific article published on 7 February 2005

Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se.

scientific article published on April 2002

Polynucleotide recognition by DNA alpha-polymerase ⬇️

scientific article published on November 1, 1977

Predicting Enhanced Cell Killing through PARP Inhibition ⬇️

scientific article published on November 27, 2012

Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate

scientific article published on 19 June 2020

Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.

scientific article published on 18 July 2013

Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.

scientific article published on 19 June 2018

Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts

scientific article published on 01 March 1997

Processive searching ability varies among members of the gap-filling DNA polymerase X family.

scientific article published on 11 September 2017

Properties of a novel oligonucleotide-releasing bidirectional DNA exonuclease from mouse myeloma.

scientific article

Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair

scientific article published on 01 January 2000

Protein-protein interactions of HIV-1 reverse transcriptase: implication of central and C-terminal regions in subunit binding ⬇️

scientific article published on December 17, 1991

Purification and characterization of a DNA polymerase beta promoter initiator element-binding transcription factor from bovine testis.

scientific article

Push and pull of base flipping

scientific article published in Nature

REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast.

scientific article published on September 2005

Rapid segmental and subdomain motions of DNA polymerase beta.

scientific article published on 27 November 2002

Recombinogenic phenotype of human activation-induced cytosine deaminase.

scientific article published on April 2004

Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain.

scientific article

Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice

scientific article published on 01 May 2003

Regulation of Acetylcholinesterase in Neuroblastoma Cells ⬇️

scientific article published on October 1, 1970

Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection

scientific article

Regulation of expression of type C virion DNA polymerase (reverse transcriptase) in human x mouse and human x rat hybrid cells ⬇️

scientific article published on November 1, 1979

Regulation of in vitro nucleic acid strand annealing activity of heterogeneous nuclear ribonucleoprotein protein A1 by reversible phosphorylation

scientific journal article

Repair pathway for PARP-1 DNA-protein crosslinks

scientific article published on 12 November 2018

Replication of O6-methylguanine-containing DNA by repair and replicative DNA polymerases

scientific article published on 01 August 1996

Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002

scientific article published on 01 May 2003

Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair".

scientific article

Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition ⬇️

scientific article published on December 3, 2010

Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

scientific article

Requirement of mammalian DNA polymerase-beta in base-excision repair.

scientific article

Requirement of mammalian DNA polymerase-β in base-excision repair

scientific article published in Nature

Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC)

scientific article published on 17 February 2020

Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer

scientific article published on 01 July 1999

Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.

scientific article published on 28 September 2016

Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography

scientific article published on 12 February 2020

Revealing the role of the product metal in DNA polymerase β catalysis

scientific article

Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure.

scientific article published on 11 July 2017

Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair

scientific article

Role of the "helix clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis

scientific article published on 01 May 1996

Role of the oxidized form of XRCC1 in protection against extreme oxidative stress

scientific article published on 4 February 2017

Selective photochemical modification by trichloroethanol of tryptophan residues in proteins with a high tyrosine-to-tryptophan ratio

scientific article published on August 15, 1992

Shining light on the response to repair intermediates in DNA of living cells

scientific article published on 12 November 2019

Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β

scientific article published on 14 September 2011

Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding ⬇️

scientific article published on August 1, 1994

Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition.

scientific article

Spotlight on DNA repair and responses to DNA damage.

scientific article published in January 2016

Steady-state kinetics of mouse DNA polymerase beta

scientific article published on July 24, 1979

Steady-state, pre-steady-state, and single-turnover kinetic measurement for DNA glycosylase activity

scientific article published on 19 August 2013

Stereospecific Formation of a Ternary Complex of (S)-α,β-Fluoromethylene-dATP with DNA Pol β

scientific article

Stimulation of DNA polymerase activity by the combination of p-hydroxymercuribenzoate and dithiothreitol

scientific article published on 01 July 1974

Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress

scientific article

Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity

scientific article published on 30 September 2013

Structural Insights into the Origins of DNA Polymerase Fidelity ⬇️

scientific article published on May 1, 2003

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

scientific article published on 20 August 2021

Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site

scientific article

Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.

scientific article

Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.

scientific article published on 19 September 2005

Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity

scientific article published on 01 October 2004

Structural insights into DNA polymerase beta fidelity: hold tight if you want it right

scientific article published on 01 January 1998

Structure and mechanism of DNA polymerase Beta.

scientific article published in February 2006

Structure and mechanism of DNA polymerase β

scientific article (publication date: 6 May 2014)

Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features

scholarly article

Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential

scientific article

Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism

scientific article

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

scientific article

Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly

scientific article

Structures of human DNA polymerases ν and θ expose their end game.

scientific article

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

scientific article

Studies of the strand-annealing activity of mammalian hnRNP complex protein A1 ⬇️

scientific article published on December 4, 1990

Studies on DNA alpha-polymerase of mouse myeloma: partial purification and comparison of three molecular forms of the enzyme

scientific article published on 01 November 1976

Studies on DNA synthesis in murine myeloma. II. Activation of latent RNA-dependent DNA polymerase activity in membrane fractions

scientific article published on 01 November 1972

Studies on the physiology of rat liver polyribosomes: quantition and intracellular distribution of ribosomes.

scientific article

Studies on the relationship between deoxyribonucleic acid polymerase activity and intracisternal A-type particles in mouse myeloma.

scientific article

Substrate channeling in mammalian base excision repair pathways: passing the baton

scientific article

Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation

scientific article published on 02 April 2014

Substrate-induced DNA polymerase β activation.

scientific article

Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases.

scientific article published in January 1998

Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.

scientific article

Syn-full behavior by T7 DNA polymerase.

scientific article published in November 2005

Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid ⬇️

scientific article published on August 19, 2010

Synthesis of DNA polymerase by in vitro translation of calf RNA

scientific article published on 01 July 1984

Synthesis of catalytically active polymerase alpha by in vitro translation of calf RNA

scientific article published on 01 January 1984

Template specific inhibitor of mammalian DNA polymerases ⬇️

scientific article published on March 1, 1976

The 3rd Japan-US DNA Repair Meeting, Sendai, Japan, May 7-11, 2007

scientific article published on 20 August 2007

The ATF/CREB transcription factor-binding site in the polymerase beta promoter mediates the positive effect of N-methyl-N'-nitro-N-nitrosoguanidine on transcription ⬇️

scientific article published on May 1, 1991

The Environmental Genome Project: phase I and beyond.

scientific article published on June 2004

The HIV-1 transactivator protein Tat is a potent inducer of the human DNA repair enzyme beta-polymerase.

scientific article published on March 2001

The Pol β variant containing exon α is deficient in DNA polymerase but has full dRP lyase activity

scientific article published on 09 July 2019

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

scientific article

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

scientific article

The X family portrait: structural insights into biological functions of X family polymerases.

scientific article

The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair.

scientific article published on 6 May 2003

The bovine DNA polymerase beta promoter: cloning, characterization and comparison with the human core promoter.

scientific article published on October 1995

The cloned promoter of the human DNA beta-polymerase gene contains a cAMP response element functional in HeLa cells

scientific article published on 01 January 1992

The dark side of DNA repair

scientific article

The domain organization and properties of individual domains of DNA topoisomerase V, a type 1B topoisomerase with DNA repair activities.

scientific article published on 3 December 2001

The fidelity of DNA polymerase beta during distributive and processive DNA synthesis

scientific article published on 01 February 1999

The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression

scientific article

Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta

scientific journal article

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

scientific article published on 15 August 2017

Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells.

scientific article

Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration.

scientific article published on 12 March 2014

Transitions in DNA polymerase β μs-ms dynamics related to substrate binding and catalysis

scientific article published on 01 August 2018

Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTP

scientific article

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

scientific article

Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer.

scientific article published on 19 July 2013

Unencumbered Pol β lyase activity in nucleosome core particles

scientific article published on September 2017

Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines ⬇️

scientific article published on April 15, 1998

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage

scientific article published on October 2006

Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove.

scientific article

Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions

scientific article published on 01 November 1998

Watching a DNA polymerase in action

scientific article published on 14 January 2014

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

scientific article published on 06 April 2021

XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks

scientific article published on January 2008

XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity.

scientific article published on 15 February 2018

XRCC1-mediated repair of strand breaks independent of PNKP binding.

scientific article published on 19 October 2017

Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme

scientific article

dNTP binding site in rat DNA polymerase beta revealed by controlled proteolysis and azido photoprobe cross-linking

scientific article published on 01 March 1996

dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog.

scientific article published in September 1996

α,β-Difluoromethylene Deoxynucleoside 5′-Triphosphates: A Convenient Synthesis of Useful Probes for DNA Polymerase β Structure and Function

scientific article

β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases

scientific article

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