List of works - Douglas A Bell

450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy

scientific article published on 31 July 2012

A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders

scientific article published on 13 April 2016

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

article published in 2018

A genetic model of differential susceptibility to human respiratory syncytial virus (RSV) infection

scientific article published on 13 January 2014

A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease

scientific article published on 27 October 2017

A pilot study testing the association between N-acetyltransferases 1 and 2 and risk of oral squamous cell carcinoma in Japanese people ⬇️

scientific article published on 01 October 1998

A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection

scientific article

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

scientific article published in PLoS ONE

Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer

journal article published in 2007

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

scientific article

Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study

scientific article published in October 2002

Beyond antioxidant genes in the ancient Nrf2 regulatory network.

scientific article published on 7 July 2015

Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood

scientific article published in May 2004

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis

scientific article published on 30 August 2017

CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest

scientific article

CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy

scientific article published in February 2005

Carotenoids/vitamin C and smoking-related bladder cancer

scientific article published in June 2004

Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

scientific article

Correction: Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes

scientific article published on 17 May 2017

Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues

article

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis

scientific article

Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants

scientific article

Dichloromethane Metabolism to Formaldehyde and Reaction of Formaldehyde with Nucleic Acids in Hepatocytes of Rodents and Humans with and without GlutathioneS-TransferaseT1andM1Genes ⬇️

scientific article published on June 1, 1997

Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies

scientific article published on 04 May 2008

Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.

scientific article

Divergent evolution of human p53 binding sites: cell cycle versus apoptosis

scientific article (publication date: July 2007)

Epigenome-wide meta-analysis of DNA methylation and childhood asthma

scientific article published in December 2018

Extended-term cultures of human T-lymphocytes: a practical alternative to primary human lymphocytes for use in genotoxicity testing ⬇️

scientific article published on 01 May 1995

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements

scientific article

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

Functional diversity in the gene network controlled by the master regulator p53 in humans.

scientific article

Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.

scientific article

Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution

scientific article

Genetic Polymorphisms in Human Drug Metabolic Enzymes, ⬇️

scientific article published on November 1, 1997

Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer

scientific article published on 09 June 2008

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer

scientific article

Global analysis of methylation profiles from high resolution CpG data

scientific article published on 23 December 2014

Glutathione S-transferase polymorphisms and survival from head and neck cancer

scientific article published in March 2005

Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study

scientific article

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution ⬇️

scientific article published on February 1, 1998

Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements

scientific article

Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe ⬇️

scientific article published on 01 February 1998

Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).

scientific article

Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression

scientific article published on 27 April 2018

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

scientific article

Identification of polymorphic antioxidant response elements in the human genome

scientific article

Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats

Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation

scientific article

Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study.

scientific article published on July 2006

Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.

scientific article

Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance?

scientific article published on 16 April 2014

N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer.

scientific article

Nomenclature for N-acetyltransferases

scientific article

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

scientific article

Novel hematopoietic target genes in the NRF2-mediated transcriptional pathway

scientific article published on 25 May 2013

Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice

scientific article

Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2.

scientific article published in March 2003

Pilot study of free and conjugated urinary mutagenicity during consumption of pan-fried meats: possible modulation by cruciferous vegetables, glutathione S-transferase-M1, and N-acetyltransferase-2 ⬇️

scientific article published on November 19, 1997

Polychlorinated biphenyl exposure and DNA methylation in the Anniston Community Health Survey

scientific article published on 14 October 2019

Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

scientific article

Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review

scientific article (publication date: 15 July 2002)

Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review

scientific article published on January 2004

Potential therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools

scientific article published on 29 October 2016

Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas

scientific article published on March 2000

Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts

scientific article published on 08 May 2009

Recombinant CYP3A417 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A417 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype.

scientific article published on 5 January 2005

Sequence context at human single nucleotide polymorphisms: overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands

scientific article published in March 2003

Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes

scientific article

Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+ nucleated red blood cells.

scientific article published on 10 June 2019

Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice

scientific article published on 05 December 2018

Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice

scientific article

The importance of p53 pathway genetics in inherited and somatic cancer genomes.

scientific article published on March 2016

The influence of humidity, sunlight, and temperature on the daytime decay of polyaromatic hydrocarbons on atmospheric soot particles ⬇️

scientific article published on 01 January 1988

Tobacco exposure-related alterations in DNA methylation and gene expression in human monocytes: the Multi-Ethnic Study of Atherosclerosis (MESA).

scientific article published on 23 November 2017

Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study

scientific article published in January 2004

Variation in fiberoptic bead-based oligonucleotide microarrays: dispersion characteristics among hybridization and biological replicate samples

scientific article

Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors

scientific article

XRCC1 polymorphisms and head and neck cancer

scientific article published on 01 April 2002

List of works by Douglas A Bell

450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy

A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

A genetic model of differential susceptibility to human respiratory syncytial virus (RSV) infection

A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease

A pilot study testing the association between N-acetyltransferases 1 and 2 and risk of oral squamous cell carcinoma in Japanese people ⬇️

A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study

Beyond antioxidant genes in the ancient Nrf2 regulatory network.

Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis

CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest

CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy

Carotenoids/vitamin C and smoking-related bladder cancer

Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

Correction: Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes

Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis

Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants

Dichloromethane Metabolism to Formaldehyde and Reaction of Formaldehyde with Nucleic Acids in Hepatocytes of Rodents and Humans with and without GlutathioneS-TransferaseT1andM1Genes ⬇️

Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies

Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.

Divergent evolution of human p53 binding sites: cell cycle versus apoptosis

Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Extended-term cultures of human T-lymphocytes: a practical alternative to primary human lymphocytes for use in genotoxicity testing ⬇️

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

Functional diversity in the gene network controlled by the master regulator p53 in humans.

Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.

Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution

Genetic Polymorphisms in Human Drug Metabolic Enzymes, ⬇️

Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer

Global analysis of methylation profiles from high resolution CpG data

Glutathione S-transferase polymorphisms and survival from head and neck cancer

Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution ⬇️

Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements

Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe ⬇️

Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).

Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

Identification of polymorphic antioxidant response elements in the human genome

Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats

Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation

Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study.

Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.

Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance?

N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer.

Nomenclature for N-acetyltransferases

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

Novel hematopoietic target genes in the NRF2-mediated transcriptional pathway

Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice

Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2.

Pilot study of free and conjugated urinary mutagenicity during consumption of pan-fried meats: possible modulation by cruciferous vegetables, glutathione S-transferase-M1, and N-acetyltransferase-2 ⬇️

Polychlorinated biphenyl exposure and DNA methylation in the Anniston Community Health Survey

Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review

Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review

Potential therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools

Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas

Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts

Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype.

Sequence context at human single nucleotide polymorphisms: overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands

Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes

Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+ nucleated red blood cells.

Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice

Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice

The importance of p53 pathway genetics in inherited and somatic cancer genomes.

The influence of humidity, sunlight, and temperature on the daytime decay of polyaromatic hydrocarbons on atmospheric soot particles ⬇️

Tobacco exposure-related alterations in DNA methylation and gene expression in human monocytes: the Multi-Ethnic Study of Atherosclerosis (MESA).

Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study

Variation in fiberoptic bead-based oligonucleotide microarrays: dispersion characteristics among hybridization and biological replicate samples

Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors

XRCC1 polymorphisms and head and neck cancer

Recombinant CYP3A417 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A417 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype.