List of works - Paul N. Barlow

1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7.

scientific article published on 13 January 2009

1H, 15N and 13C resonance assignments of complement control protein module pair 2-3 from the C4b-binding site of complement receptor type 1

scientific article published on 01 October 2004

1H, 15N and 13C resonance assignments of the C345C domain of the complement component C5.

scientific article published in June 2004

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

scientific article

A new map of glycosaminoglycan and C3b binding sites on factor H

scientific article

A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7

An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy

scientific article published on 27 March 2018

An atomic resolution model for assembly, architecture, and function of the Dr adhesins.

scientific article

An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin

scientific article published on 21 November 2008

Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells

scientific article

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

scientific article

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces

scientific article published in May 2004

Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.

scientific article

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis

scientific article

Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade

scientific article published on 12 November 2019

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation.

scientific article

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

scientific article

Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

Complement factor H: using atomic resolution structure to illuminate disease mechanisms

scientific article

Complement factor h autoantibodies and age-related macular degeneration.

scientific article

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages

scientific article published on 06 March 2020

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand ⬇️

scientific article published on 20 September 2010

Creating functional sophistication from simple protein building blocks, exemplified by factor H and the regulators of complement activation

scientific article

Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces

scientific article published on 01 November 2006

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

scientific article

Deciphering complement mechanisms: the contributions of structural biology

scientific article published on September 2007

Decoding the components of dynamics in three-domain proteins.

scientific article

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities

scientific article

Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure

scientific article

Disease-associated sequence variations in factor H: a structural biology approach

scientific article

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation

scientific article published on 21 June 2017

Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)

scientific article published in Journal of Biological Chemistry

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

scientific article

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings

scientific article published on 31 August 2011

Factor H autoantibodies in membranoproliferative glomerulonephritis.

scientific article published on 20 June 2012

Functional anatomy of complement factor H.

scientific article published on 31 May 2013

Functional insights from the structure of the multifunctional C345C domain of C5 of complement

scientific article

Genome-Wide Association Studies Identify Disease Mechanisms in Age-Related Macular Degeneration

scientific article published on 01 July 2018

Grasping the nettle: A bacterial invasin that targets immunoglobulin variable domains.

scientific article published in June 2018

Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor

scientific article

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

scholarly article by Kate Smith-Jackson et al published 4 February 2019 in Journal of Clinical Investigation

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

scholarly article

Large-scale modelling as a route to multiple surface comparisons of the CCP module family

article

Last of the..

scientific article published in Nature

Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor

scientific article published in June 2002

Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.

scientific article published on May 2010

MDM4 binds ligands via a mechanism in which disordered regions become structured

scientific article

Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.

scientific article

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

scientific article

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes ⬇️

scientific article published on 24 April 2019

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

scientific article

New approaches to the treatment of dense deposit disease

scientific article published on 5 August 2007

Opportunities for new therapies based on the natural regulators of complement activation

scientific article

Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes ⬇️

scholarly article

Polychromatic selective population inversion for TROSY experiments with large proteins

scientific article published on 01 January 2005

Production of biologically active complement factor H in therapeutically useful quantities ⬇️

scientific article published on December 10, 2010

Quantitative cross-linking/mass spectrometry reveals subtle protein conformational changes

scientific article

Rational engineering of a minimized immune inhibitor with unique triple-targeting properties

scientific article published on 24 April 2013

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

scientific article (publication date: February 2016)

Resonance assignments of the central complement control protein module pair of human decay accelerating factor

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes ⬇️

scientific article (publication date: February 2015)

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

scientific article

Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement

scientific article

Solution structure of a functionally active fragment of decay-accelerating factor

scientific article (publication date: 15 April 2003)

Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin

scientific article

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

scientific article published in 2012

Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

scientific journal article

Structural and functional characterization of the product of disease-related factor H gene conversion

scientific article

Structural basis and functional effects of the interaction between complement inhibitor C4b-binding protein and DNA

scientific article published on 19 August 2008

Structural basis for complement factor H linked age-related macular degeneration

scientific article

Structural basis for engagement by complement factor H of C3b on a self surface

scientific article

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

scientific article

Structure and flexibility of the multiple domain proteins that regulate complement activation

scientific article (publication date: April 2001)

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

scientific article published on June 2016

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

scientific article

Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor

scientific article

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

scientific article

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism

scientific article

Structure-based Mapping of DAF Active Site Residues That Accelerate the Decay of C3 Convertases

scientific article published in Journal of Biological Chemistry

Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core

scientific article

The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

scientific article

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module

scientific article

The interaction of Jagged-1 cytoplasmic tail with afadin PDZ domain is local, folding-independent, and tuned by phosphorylation.

scientific article published in March 2011

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.

scientific article

The pluripotency rheostat Nanog functions as a dimer

scientific article

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function

scientific journal article

Towards a structural basis for complement factor H linked age-related macular degeneration

Use of time‐resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus) ⬇️

scientific article published on December 1, 2011

Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor

scientific article

Utilising ion mobility-mass spectrometry to interrogate macromolecules: Factor H complement control protein modules 10–15 and 19–20 and the DNA-binding core domain of tumour suppressor p53

article

Vaccinia virus complement control protein is monomeric, and retains structural and functional integrity after exposure to adverse conditions

scientific article published in July 2002

¹H, ¹³C and ¹⁵N resonance assignments of the complement control protein modules of the complement component C7.

scientific article published on September 28, 2012

List of works by Paul N. Barlow

1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7.

1H, 15N and 13C resonance assignments of complement control protein module pair 2-3 from the C4b-binding site of complement receptor type 1

1H, 15N and 13C resonance assignments of the C345C domain of the complement component C5.

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

A new map of glycosaminoglycan and C3b binding sites on factor H

A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7

An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy

An atomic resolution model for assembly, architecture, and function of the Dr adhesins.

An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin

Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces

Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis

Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation.

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

Complement factor H: using atomic resolution structure to illuminate disease mechanisms

Complement factor h autoantibodies and age-related macular degeneration.

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand ⬇️

Creating functional sophistication from simple protein building blocks, exemplified by factor H and the regulators of complement activation

Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

Deciphering complement mechanisms: the contributions of structural biology

Decoding the components of dynamics in three-domain proteins.

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities

Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure

Disease-associated sequence variations in factor H: a structural biology approach

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation

Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings

Factor H autoantibodies in membranoproliferative glomerulonephritis.

Functional anatomy of complement factor H.

Functional insights from the structure of the multifunctional C345C domain of C5 of complement

Genome-Wide Association Studies Identify Disease Mechanisms in Age-Related Macular Degeneration

Grasping the nettle: A bacterial invasin that targets immunoglobulin variable domains.

Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

Large-scale modelling as a route to multiple surface comparisons of the CCP module family

Last of the..

Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor

Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.

MDM4 binds ligands via a mechanism in which disordered regions become structured

Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes ⬇️

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

New approaches to the treatment of dense deposit disease

Opportunities for new therapies based on the natural regulators of complement activation

Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes ⬇️

Polychromatic selective population inversion for TROSY experiments with large proteins

Production of biologically active complement factor H in therapeutically useful quantities ⬇️

Quantitative cross-linking/mass spectrometry reveals subtle protein conformational changes

Rational engineering of a minimized immune inhibitor with unique triple-targeting properties

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

Resonance assignments of the central complement control protein module pair of human decay accelerating factor

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes ⬇️

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement

Solution structure of a functionally active fragment of decay-accelerating factor

Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

Structural and functional characterization of the product of disease-related factor H gene conversion

Structural basis and functional effects of the interaction between complement inhibitor C4b-binding protein and DNA

Structural basis for complement factor H linked age-related macular degeneration

Structural basis for engagement by complement factor H of C3b on a self surface

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

Structure and flexibility of the multiple domain proteins that regulate complement activation

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism