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List of works by Ian M Copple

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

scientific article published on 24 May 2017

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.

scientific article

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.

scientific article published on 21 April 2017

Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids

scientific article

Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies

scientific article published on 11 April 2017

Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

scientific article published on 18 January 2019

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

scientific article published on 23 February 2016

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications

scientific article

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

scientific article

NRF2 as an Emerging Therapeutic Target.

scientific article published on 31 January 2017

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.

scientific article published on 4 April 2018

Optimising the use of medicines to reduce acute kidney injury in children and babies.

scientific article published on 12 February 2017

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.

scientific article published on 22 November 2017

Role of Nrf2 in protection against acute kidney injury ⬇️

scientific article published on June 19, 2013

The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

scientific article published on January 2012

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

scientific article published on 5 June 2018

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

scientific article

The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.

scientific article published on January 2010

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

scientific article

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