List of works - Axel Mogk

A Gatekeeper Residue of ClpS1 from Arabidopsis thaliana Chloroplasts Determines its Affinity Towards Substrates of the Bacterial N-End Rule

A PDZ switch for a cellular stress response

scientific article published on May 2004

A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins

scientific article

A tightly regulated molecular toggle controls AAA+ disaggregase.

scientific article published on 18 November 2012

AAA+ proteins and substrate recognition, it all depends on their partner in crime

scientific article

Adaptor protein controlled oligomerization activates the AAA+ protein ClpC

scientific article

Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins

scientific article

Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70.

scientific article published on 8 September 2016

Broad yet high substrate specificity: the challenge of AAA+ proteins

scientific article published on April 2004

Cellular Handling of Protein Aggregates by Disaggregation Machines

scientific article published in January 2018

Cellular strategies for controlling protein aggregation

scientific article

Chaperone networks in protein disaggregation and prion propagation

scientific article published on 10 May 2012

Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli

scientific article

Characterization of ClpS2, an essential adaptor protein for the cyanobacterium Synechococcus elongatus

scientific article published on 20 November 2015

Characterization of a trap mutant of the AAA+ chaperone ClpB.

scientific article

ClpS is the recognition component for Escherichia coli substrates of the N-end rule degradation pathway

scientific article published on 17 March 2009

ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria

scientific article published on November 2005

Common and specific mechanisms of AAA+ proteins involved in protein quality control

scientific article published on February 2008

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

scientific article

Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding

scientific article

Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation

scientific article

Coordination of translational control and protein homeostasis during severe heat stress

scientific article

Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity.

scientific article

Deadly syringes: type VI secretion system activities in pathogenicity and interbacterial competition ⬇️

scientific article published on 02 January 2013

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

scientific article

Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae

scientific article

Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding.

scientific article published on 20 February 2017

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces.

scientific article published on 18 November 2012

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

scientific article published on August 2012

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils

scientific article published on 19 August 2015

Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers

scientific article published on 25 November 2015

Integrating protein homeostasis strategies in prokaryotes

scientific article published on April 2011

Interaction specificity between the chaperone and proteolytic components of the cyanobacterial Clp protease ⬇️

scientific article published on September 1, 2012

M domains couple the ClpB threading motor with the DnaK chaperone activity

scientific article published in January 2007

MecA, an adaptor protein necessary for ClpC chaperone activity

scholarly article

Mechanisms of protein folding: molecular chaperones and their application in biotechnology

scientific article

Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion

scientific article

Molecular chaperones: structure of a protein disaggregase

scientific article published on January 2004

Monitoring protein misfolding by site-specific labeling of proteins in vivo

scientific article

Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase ⬇️

scientific article published on 22 February 2017

Novel insights into the mechanism of chaperone-assisted protein disaggregation

scientific article

Poly-L-lysine enhances the protein disaggregation activity of ClpB.

scientific article published in October 2003

Prevention and reversion of protein aggregation by molecular chaperones in the E. coli cytosol: implications for their applicability in biotechnology

scientific article

Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

scientific article published on 22 September 2009

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae

scientific article published on 11 March 2015

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.

scientific article

Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease pim1.

scientific article published on February 2006

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

scientific article

Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

scientific article

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

scientific article published on 22 November 2017

Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion

scientific article

Role of sHsps in organizing cytosolic protein aggregation and disaggregation

scientific article published on 24 January 2017

Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity

scientific article published on 6 March 2003

Signature of protein unfolding in chemical exchange saturation transfer imaging

scientific article

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding.

scientific article

Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides

scientific article published in December 2004

Spatially organized aggregation of misfolded proteins as cellular stress defense strategy

scientific article

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria

scientific article published on 20 December 2017

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

scientific article

Structure and function of a novel type of ATP-dependent Clp protease

scientific article published on 23 February 2009

Structure of the VipA/B type VI secretion complex suggests a contraction-state-specific recycling mechanism

scientific article published on 19 June 2014

Substrate recognition by the AAA+ chaperone ClpB.

scientific article

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

scientific article published on 28 February 2008

The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies

scientific article published on 15 February 2007

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

scientific article

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

scientific article

The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins

scientific article published on 27 April 2009

Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

scientific article

Total Synthesis and Biological Evaluation of Modified Ilamycin Derivatives

scientific article published in 2022

Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation

scientific article published on February 2010

Trigger Factor and DnaK possess overlapping substrate pools and binding specificities

scientific article

Tubules and donuts: a type VI secretion story

scientific article published on 23 April 2010

Unscrambling an egg: protein disaggregation by AAA+ proteins

scientific article

List of works by Axel Mogk

A Gatekeeper Residue of ClpS1 from Arabidopsis thaliana Chloroplasts Determines its Affinity Towards Substrates of the Bacterial N-End Rule

A PDZ switch for a cellular stress response

A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins

A tightly regulated molecular toggle controls AAA+ disaggregase.

AAA+ proteins and substrate recognition, it all depends on their partner in crime

Adaptor protein controlled oligomerization activates the AAA+ protein ClpC

Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins

Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70.

Broad yet high substrate specificity: the challenge of AAA+ proteins

Cellular Handling of Protein Aggregates by Disaggregation Machines

Cellular strategies for controlling protein aggregation

Chaperone networks in protein disaggregation and prion propagation

Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli

Characterization of ClpS2, an essential adaptor protein for the cyanobacterium Synechococcus elongatus

Characterization of a trap mutant of the AAA+ chaperone ClpB.

ClpS is the recognition component for Escherichia coli substrates of the N-end rule degradation pathway

ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria

Common and specific mechanisms of AAA+ proteins involved in protein quality control

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding

Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation

Coordination of translational control and protein homeostasis during severe heat stress

Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity.

Deadly syringes: type VI secretion system activities in pathogenicity and interbacterial competition ⬇️

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae

Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding.

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces.

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils

Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers

Integrating protein homeostasis strategies in prokaryotes

Interaction specificity between the chaperone and proteolytic components of the cyanobacterial Clp protease ⬇️

M domains couple the ClpB threading motor with the DnaK chaperone activity

MecA, an adaptor protein necessary for ClpC chaperone activity

Mechanisms of protein folding: molecular chaperones and their application in biotechnology

Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion

Molecular chaperones: structure of a protein disaggregase

Monitoring protein misfolding by site-specific labeling of proteins in vivo

Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase ⬇️

Novel insights into the mechanism of chaperone-assisted protein disaggregation

Poly-L-lysine enhances the protein disaggregation activity of ClpB.

Prevention and reversion of protein aggregation by molecular chaperones in the E. coli cytosol: implications for their applicability in biotechnology

Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.

Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease pim1.

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion

Role of sHsps in organizing cytosolic protein aggregation and disaggregation

Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity

Signature of protein unfolding in chemical exchange saturation transfer imaging

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding.

Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides

Spatially organized aggregation of misfolded proteins as cellular stress defense strategy

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Structure and function of a novel type of ATP-dependent Clp protease

Structure of the VipA/B type VI secretion complex suggests a contraction-state-specific recycling mechanism

Substrate recognition by the AAA+ chaperone ClpB.

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins

Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

Total Synthesis and Biological Evaluation of Modified Ilamycin Derivatives

Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation

Trigger Factor and DnaK possess overlapping substrate pools and binding specificities

Tubules and donuts: a type VI secretion story

Unscrambling an egg: protein disaggregation by AAA+ proteins