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List of works by Judith Frydman

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement

scientific article

A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability

scientific article published on 01 October 2018

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

scientific article published on 30 October 2014

A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle

scientific article published on 4 October 2012

A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis

scientific article

Aberrant protein folding as the molecular basis of cancer

scientific article

Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation

scientific article

Action of the chaperonin GroEL/ES on a non-native substrate observed with single-molecule FRET.

scientific article

An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex ⬇️

scientific article published on June 1, 1992

An information theoretic framework reveals a tunable allosteric network in group II chaperonins

scientific article

Broad action of Hsp90 as a host chaperone required for viral replication

scientific article published on 02 December 2011

Cellular inclusion bodies of mutant huntingtin exon 1 obscure small fibrillar aggregate species

scientific article

Cellular strategies of protein quality control

scientific article

Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro

scientific article published on 27 October 2005

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

scientific article published on 17 June 2014

Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis

scientific article published in May 2003

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

scientific article published on 18 October 2016

Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis

scientific article published on 18 August 2021

Cotranslational signal-independent SRP preloading during membrane targeting

scientific article published on 3 August 2016

Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure

scientific article

CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin

scientific article published on 06 August 2021

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

scholarly article

Crystal Structures of a Group II Chaperonin Reveal the Open and Closed States Associated with the Protein Folding Cycle

scientific article

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

scientific article published on 11 November 2015

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

scientific article

Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes

scientific article

Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation

scientific article

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

scientific article published on 30 March 2020

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

scientific article published in Nature

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

scientific article

Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy

scientific article published on 01 August 2019

Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber

scientific article

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

scientific article published on 11 April 2019

Dynamics and clustering of IRE1α during ER stress

scientific article published on 04 February 2020

Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins

scientific article published on 29 April 2007

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

scientific article published on 23 December 2012

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

scientific article published on January 2007

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

scientific article

Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways

scientific article published on 01 June 2005

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

scientific article published in Nature

Hardware-based anti-Brownian electrokinetic trap (ABEL trap) for single molecules: Control loop simulations and application to ATP binding stoichiometry in multi-subunit enzymes

scientific article published on August 2008

Heterozygous yeast deletion collection screens reveal essential targets of Hsp90

scientific article published in 2011

Hsp110 cooperates with different cytosolic HSP70 systems in a pathway for de novo folding

scientific article

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

article published in 2017

Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus

scientific article

Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.

scientific article

Huntingtin’s N-Terminus Rearrangements in the Presence of Membranes: A Joint Spectroscopic and Computational Perspective

scientific article published on 17 September 2018

Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins

scientific article published in October 2006

Interplay between chaperones and protein disorder promotes the evolution of protein networks

scientific article

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

scientific article published on 24 November 2014

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

scientific article published on 15 March 2018

Mechanism of folding chamber closure in a group II chaperonin

scientific article

Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT

scientific article published on 8 June 2008

Mechanism of nucleotide sensing in group II chaperonins

scientific article

Mechanism of nucleotide sensing in group II chaperonins

scientific article published in October 2012

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

scientific article

Mechanisms and Functions of Spatial Protein Quality Control

scientific article published on 10 May 2017

Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae

scientific article published on 08 February 2019

Misfolded proteins partition between two distinct quality control compartments

scientific article

Modeling of possible subunit arrangements in the eukaryotic chaperonin TRiC.

scientific article published on 2 May 2006

Modulation of STAT3 folding and function by TRiC/CCT chaperonin

scientific article

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

scientific article published on 5 December 2016

Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT

scientific article published on 07 August 2019

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein

scientific journal article

Principles of cotranslational ubiquitination and quality control at the ribosome

scientific article published on 11 April 2013

Probing the sequence of conformationally induced polarity changes in the molecular chaperonin GroEL with fluorescence spectroscopy

scientific article

Protein misfolding in neurodegenerative diseases: implications and strategies

scientific article published on 13 March 2017

Protein quality control: chaperones culling corrupt conformations

scientific article published on August 2005

Proteostasis in Viral Infection: Unfolding the Complex Virus-Chaperone Interplay

scientific article published on 02 March 2020

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

scientific article

REP-X: An Evolution-guided Strategy for the Rational Design of Cysteine-less Protein Variants

scientific article published on 10 February 2020

Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution

scientific article

Sorting out the trash: the spatial nature of eukaryotic protein quality control

scientific article

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

scientific article

State of the science: an update on renal cell carcinoma

scientific article

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective

scientific article

Sub-diffraction imaging of huntingtin protein aggregates by fluorescence blink-microscopy and atomic force microscopy

scientific article

Super-resolution fluorescence imaging of intracellular mutant huntingtin protein reveals a population of fibrillar aggregates co-existing with compact perinuclear inclusion bodies

Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates

scientific article

Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle

scientific article

Systematic functional prioritization of protein posttranslational modifications

scientific article

Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells

scientific article

TRiC's tricks inhibit huntingtin aggregation

scientific article published on 09 July 2013

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story

scientific article published on 09 April 2019

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

scientific article published on 04 April 2019

The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex

scientific article

The Hsp90 mosaic: a picture emerges

scientific article published in January 2009

The Mechanism and Function of Group II Chaperonins

scientific article published on 29 April 2015

The TRiC chaperonin controls reovirus replication through outer-capsid folding

scientific article published on 12 March 2018

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

scientific article published on 15 November 2009

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

scientific article

The cotranslational contacts between ribosome-bound nascent polypeptides and the subunits of the hetero-oligomeric chaperonin TRiC probed by photocross-linking

scientific article published on 30 May 2005

The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis

scientific article

The dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulation

scientific article

The molecular architecture of the eukaryotic chaperonin TRiC/CCT

scientific article

The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation

scientific article

The ribosome as a hub for protein quality control

scientific article published on February 2013

The role of mutational robustness in RNA virus evolution

scientific article published on 25 March 2013

The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis

scientific article published on 30 November 2018

The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT

scientific journal article

Time-Resolved Measurement of the ATP-Dependent Motion of the Group II Chaperonin by Diffracted Electron Tracking

scientific article published on 22 March 2018

Tracheostomy and mechanical ventilation weaning in children affected by respiratory virus according to a weaning protocol in a pediatric intensive care unit in Argentina: an observational restrospective trial ⬇️

scientific article published on January 19, 2011

Trivalent arsenic inhibits the functions of chaperonin complex

scientific article

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding

scientific article published on November 2003

Where chaperones and nascent polypeptides meet

scientific article published on 01 October 2002

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease

scientific article published on 01 January 2019

xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry

scientific article

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