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List of works by Doug A Brooks

A Molecular Probe for the Detection of Polar Lipids in Live Cells

scientific article

A differentiation antigen expressed selectively by a proportion of human blood cells: detection with a monoclonal antibody

scientific article published on 01 January 1982

A membrane protein primarily associated with the lysosomal compartment

scientific article published on 01 July 1997

A role for altered phagosome maturation in the long-term persistence of Helicobacter pylori infection

scientific article

Absence of α-galactosidase cross-correction in Fabry heterozygote cultured skin fibroblasts

scientific article published on 12 November 2014

Activation of IGF-2R stimulates cardiomyocyte hypertrophy in the late gestation sheep fetus.

scientific article published on 28 August 2012

Adverse Intrauterine Environment and Cardiac miRNA Expression.

scientific article published on 6 December 2017

Akt signaling as a mediator of cardiac adaptation to low birth weight.

scientific article published on 20 February 2017

Alteration of cardiac glucose metabolism in association to low birth weight: experimental evidence in lambs with left ventricular hypertrophy.

scientific article published on 5 August 2013

Altered endosome biogenesis in prostate cancer has biomarker potential

scientific article published on 30 July 2014

Altered trafficking and turnover of LAMP-1 in Pompe disease-affected cells.

scientific article published on March 1999

Aminoglycoside-Induced Premature Stop Codon Read-Through of Mucopolysaccharidosis Type I Patient Q70X and W402X Mutations in Cultured Cells.

scientific article

An improved method for the purification of IgG monoclonal antibodies from culture supernatants

scientific article published on 01 October 1992

An index case for the attenuated end of the mucopolysaccharidosis type VI clinical spectrum

scientific article published on 24 March 2005

Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes

scientific article published on 9 September 2015

Beyond PSA testing for prostate cancer

scientific article published on 01 June 2018

Common antigenicity for two glycosidases

scientific article published on 06 December 2005

Delineation of serologically distinct monomorphic determinants of human MHC class II antigens: evidence of heterogeneity in their topographical distribution

scientific article published on 01 March 1984

Detection of mucopolysaccharidosis type II by measurement of iduronate-2-sulfatase in dried blood spots and plasma samples.

scientific article published on 23 February 2006

Developmental changes and fructose absorption in children: effect on malabsorption testing and dietary management.

scientific article published on May 2013

Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo

scientific article published on 17 May 2016

Drug induced exocytosis of glycogen in Pompe disease.

scientific article published on 28 September 2016

Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion

scientific article published in February 2018

Early origins of heart disease: low birth weight and determinants of cardiomyocyte endowment

scientific article

Early origins of heart disease: low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy.

scientific article

Effect of age on fructose malabsorption in children presenting with gastrointestinal symptoms.

scientific article published on May 2011

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

scientific article

Endosomal gene expression: a new indicator for prostate cancer patient prognosis?

scientific article published on 14 October 2015

Enzyme replacement therapy in mucopolysaccharidosis I: altered distribution and targeting of alpha-L-iduronidase in immunized rats

scientific article published on 01 April 2000

Experimental gingivitis in humans. A histochemical and immunological characterization of the lymphoid cell subpopulations

scientific article published on 01 July 1983

Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb.

scientific article

Getting into the fold

scientific article published on 01 February 2007

Glycosidase active site mutations in human alpha-L-iduronidase.

scientific article published on September 2001

Helicobacter pylori phagosome maturation in primary human macrophages.

scientific article

Human N-acetylgalactosamine-4-sulphatase biosynthesis and maturation in normal, Maroteaux-Lamy and multiple-sulphatase-deficient fibroblasts.

scientific article published on June 1990

Hurler syndrome: A patient with abnormally high levels of α-l-iduronidase protein ⬇️

scientific article published on June 1, 1992

IGF-2R-Gαq signaling and cardiac hypertrophy in the low-birth-weight lamb

scientific article

IGF-2R-mediated signaling results in hypertrophy of cultured cardiomyocytes from fetal sheep.

scientific article published on 22 June 2012

Iduronate-2-sulphatase protein detection in plasma from mucopolysaccharidosis type II patients

scientific article published on 01 January 2004

Imaging and lipidomics methods for lipid analysis in metabolic and cardiovascular disease

scientific article

Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time.

scientific article published on 20 August 2016

Immune response to enzyme replacement therapy in lysosomal storage disorder patients and animal models.

scientific article

Immune response to enzyme replacement therapy: 4-sulfatase epitope reactivity of plasma antibodies from MPS VI cats

scientific article published on 01 July 1999

Immune response to enzyme replacement therapy: clinical signs of hypersensitivity reactions and altered enzyme distribution in a high titre rat model.

scientific article

Immune response to enzyme replacement therapy: single epitope control of antigen distribution from circulation

scientific article published on 01 September 2002

Immune tolerance after long-term enzyme-replacement therapy among patients who have mucopolysaccharidosis I ⬇️

scientific article published on May 10, 2003

Immunochemical analysis of CD107a (LAMP-1)

scientific article published on 01 July 2005

Immunochemical characterization of feline and human N-acetylgalactosamine 4-sulfatase

scientific article published on 01 October 1994

Immunochemistry of lysosomal storage disorders.

scientific article published on 13 July 2006

Immunopurification and characterization of human alpha-L-iduronidase with the use of monoclonal antibodies

scientific article

Immunoquantification of alpha-galactosidase: evaluation for the diagnosis of Fabry disease

scientific article published on 13 September 2004

Immunoquantification of the low abundance lysosomal enzyme N-acetylgalactosamine 4-sulphatase

scientific article published on 01 January 1990

In vivo delivery of human alpha-L-iduronidase in mice implanted with neo-organs

scientific article published on 01 September 1995

Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice

scientific article published on 21 September 2020

Intestinal fructose transport and malabsorption in humans.

scientific article published on 09 December 2010

Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging

scientific article published on 02 December 2016

Introduction: molecular chaperones of the ER: their role in protein folding and genetic disease

scientific article published on 01 October 1999

Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells.

scientific article

Is Small-bowel Bacterial Overgrowth an Underdiagnosed Disorder in Children With Gastrointestinal Symptoms?

scientific article published on 01 May 2011

Label-free imaging of healthy and infarcted fetal sheep hearts by two-photon microscopy.

scientific article

Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart

scientific article published on 23 October 2017

Laronidase treatment of mucopolysaccharidosis I.

scientific article

Long-term clinical progress in bone marrow transplanted mucopolysaccharidosis type I patients with a defined genotype

scientific article published on 01 January 1993

Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life

scientific article

Lysosomal Biogenesis in Lysosomal Storage Disorders ⬇️

scientific article published on July 10, 1997

Lysosomal storage disease: revealing lysosomal function and physiology.

scientific article published on April 2010

Mass spectrometric quantification of glycogen to assess primary substrate accumulation in the Pompe mouse ⬇️

scientific article published on December 20, 2011

Membrane antigens of human cells of the monocyte/macrophage lineage studied with monoclonal antibodies

scientific article published on 01 January 1983

Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex.

scientific article

Monoclonal Antibody-Defined B Cell Subsets in Aging Humans and Down’s Syndrome ⬇️

scientific article published on 01 January 1984

Monoclonal antibodies against antigens of the human platelet surface: preparation and properties

scientific article published on 01 January 1984

Monocyte and macrophage killing of helicobacter pylori: relationship to bacterial virulence factors

scientific article published on 01 October 2008

Mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome): a Y210C mutation causes either altered protein handling or altered protein function of N-acetylgalactosamine 4-sulfatase at multiple points in the vacuolar network.

scientific article

Mutational analysis of mucopolysaccharidosis type VI patients undergoing a phase II trial of enzyme replacement therapy

scientific article published on 11 December 2006

Mutational analysis of mucopolysaccharidosis type VI patients undergoing a trial of enzyme replacement therapy.

scientific article published on March 2004

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

scientific article

N-acetylgalactosamine-6-sulfatase protein detection in MPS IVA patient and unaffected control samples.

scientific article published in September 2006

Neonatal gene therapy with a gamma retroviral vector in mucopolysaccharidosis VI cats.

scientific article

Newborn screening for lysosomal storage disorders

scientific article published on 04 April 2006

Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane

scientific article published on 03 October 2018

Prediction of neuropathology in mucopolysaccharidosis I patients.

scientific article published on January 2005

Processing of normal lysosomal and mutant N-acetylgalactosamine 4-sulphatase: BiP (immunoglobulin heavy-chain binding protein) may interact with critical protein contact sites.

scientific article

Prostate cell lines as models for biomarker discovery: performance of current markers and the search for new biomarkers

scientific article published on 16 January 2014

Protein processing: a role in the pathophysiology of genetic disease.

scientific article published on June 1997

Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3ε in Metabolic Pathways

scientific article published on 3 April 2017

Regulation of microRNA during cardiomyocyte maturation in sheep.

scientific article published on 22 July 2015

Replacement therapy in Mucopolysaccharidosis type VI: advantages of early onset of therapy.

scientific article published in March 2003

Review: the immunochemical analysis of enzyme from mucopolysaccharidoses patients.

scientific article

Role of immune serum in the killing of Helicobacter pylori by macrophages.

scientific article published in June 2010

Significance of immune response to enzyme-replacement therapy for patients with a lysosomal storage disorder.

scientific article published on October 2003

Stop-codon read-through for patients affected by a lysosomal storage disorder.

scientific article published on 23 June 2006

Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion

scientific article

Synthesis, photophysical and cellular characterisation of folate and methotrexate labelled luminescent lanthanide complexes.

scientific article published on 10 October 2017

Targeting prostate cancer cells with genetically engineered polypeptide-based micelles displaying gastrin-releasing peptide

scientific article published on 12 September 2016

The alpha-L-iduronidase mutations R89Q and R89W result in an attenuated mucopolysaccharidosis type I clinical presentation.

scientific article published in October 2003

The identification of lymphoid cell subpopulations in sections of human lymphoid tissue and gingivitis in children using monoclonal antibodies

scientific article published on 01 May 1982

The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults

scientific article published on 28 June 2018

The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.

scientific article

Two site-directed mutations abrogate enzyme activity but have different effects on the conformation and cellular content of the N-acetylgalactosamine 4-sulphatase protein

scientific article

Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes.

scientific article

alpha-L-iduronidase premature stop codons and potential read-through in mucopolysaccharidosis type I patients.

scientific article published in April 2004

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