List of works - Christian Wiesmann

A role of macrophage complement receptor CRIg in immune clearance and inflammation.

scientific article published on 26 August 2008

A small-molecule inhibitor of C5 complement protein

scientific article published on 17 June 2019

A structure-based database of antibody variable domain diversity.

scientific article

Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization.

scientific article published on 24 March 2007

Allosteric inhibition of protein tyrosine phosphatase 1B.

scientific article published on 18 July 2004

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

scientific article published in May 2009

Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

scientific article

Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families.

scientific article published on 31 May 2006

Cryo-EM in drug discovery: achievements, limitations and prospects

article

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor ⬇️

scientific article published on November 28, 1997

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

scientific article

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

scientific article

Crystal structure of the complex between VEGF and a receptor-blocking peptide

scientific article

Crystal structures and mechanism of 6-phospho-β-galactosidase from Lactococcus lactis 1 1Edited by R. Huber ⬇️

scientific article published on June 27, 1997

Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC

scientific article

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

scientific article

Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor

scientific article

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer ⬇️

scientific article published on October 7, 2011

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions

scientific article

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

scientific article

Human Memory B Cells Harbor Diverse Cross-Neutralizing Antibodies against BK and JC Polyomaviruses

scientific article published on 26 February 2019

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation

scientific article

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

scientific article

Inhibition of Wnt signaling by Dishevelled PDZ peptides

scientific article

Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.

scientific article

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

scientific article

Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies

scholarly article

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

scientific article

On the edge of validation--cancer protease fibroblast activation protein.

scientific article published on June 2008

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform ⬇️

scientific article published on October 21, 2011

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

scientific article published on 29 March 2019

Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states

scientific article

Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3

scientific article

Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

scientific article

Structural determinants of MALT1 protease activity

scientific article

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

scientific article

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering

scientific article

Structure of neprilysin in complex with the active metabolite of sacubitril

scientific article published on 15 June 2016

Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.

scientific article published in February 2018

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase ⬇️

scientific article published on May 13, 2011

Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.

scientific article published on 22 December 2005

Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP

scientific article published on 01 December 2006

Targeted inhibition of the COP9 signalosome for treatment of cancer

scientific article published on 24 October 2016

The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1

scientific article

The development of peptide-based tools for the analysis of angiogenesis

scientific article

The discovery of first-in-class drugs: origins and evolution.

scientific article

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

scientific article

Variations on ligand-receptor complexes

scientific article published on 01 June 2000

List of works by Christian Wiesmann

A role of macrophage complement receptor CRIg in immune clearance and inflammation.

A small-molecule inhibitor of C5 complement protein

A structure-based database of antibody variable domain diversity.

Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization.

Allosteric inhibition of protein tyrosine phosphatase 1B.

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families.

Cryo-EM in drug discovery: achievements, limitations and prospects

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor ⬇️

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

Crystal structure of the complex between VEGF and a receptor-blocking peptide

Crystal structures and mechanism of 6-phospho-β-galactosidase from Lactococcus lactis 1 1Edited by R. Huber ⬇️

Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer ⬇️

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

Human Memory B Cells Harbor Diverse Cross-Neutralizing Antibodies against BK and JC Polyomaviruses

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

Inhibition of Wnt signaling by Dishevelled PDZ peptides

Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

On the edge of validation--cancer protease fibroblast activation protein.

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform ⬇️

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states

Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3

Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

Structural determinants of MALT1 protease activity

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering

Structure of neprilysin in complex with the active metabolite of sacubitril

Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase ⬇️

Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.

Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP

Targeted inhibition of the COP9 signalosome for treatment of cancer

The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1

The development of peptide-based tools for the analysis of angiogenesis

The discovery of first-in-class drugs: origins and evolution.

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

Variations on ligand-receptor complexes