Search filters

List of works by Claudia Wellbrock

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF /AXL melanoma

scientific article published on 19 October 2018

A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors.

scientific article

Activating mutations in the extracellular domain of the melanoma inducing receptor Xmrk are tumorigenic in vivo.

scientific article published in December 2005

Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling.

scientific article published on 4 December 2001

Activation of phosphatidylinositol 3-kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells

scientific article published on 01 June 2000

Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations

scientific article published on 01 April 1998

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

scientific article

BRAF as therapeutic target in melanoma

scientific article published on 27 March 2010

Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing.

scientific article published on 16 March 2018

Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion ⬇️

scientific article published on February 6, 2012

Cooperative behaviour and phenotype plasticity evolve during melanoma progression

scientific article published on 07 March 2020

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

scientific article

Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma

scientific article published on 17 December 2012

Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation

scientific article published on August 2005

FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2

scientific article published on 12 July 2006

Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth.

scientific article published on 23 March 2017

Heterogeneous tumor subpopulations cooperate to drive invasion

scientific article

Identification of a second egfr gene in Xiphophorus uncovers an expansion of the epidermal growth factor receptor family in fish.

scientific article published on 5 December 2003

In melanoma, beta-catenin is a suppressor of invasion.

scientific article published on 16 May 2011

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

scientific article published on March 2016

MAPK pathway inhibition in melanoma: resistance three ways

scientific article

MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide

scientific article

MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma

scientific article (publication date: 27 November 2003)

Melanoma and the Microenvironment--Age Matters.

scientific article published in August 2016

Melanoma biology and new targeted therapy

scientific article published on February 2007

Melanoma development and pigment cell transformation in xiphophorus.

scientific article

Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy.

scientific article published on 17 April 2015

Molecular Pathways: Maintaining MAPK Inhibitor Sensitivity by Targeting Nonmutational Tolerance.

scientific article published on 19 October 2016

Multiple binding sites in the growth factor receptor Xmrk mediate binding to p59fyn, GRB2 and Shc.

scientific article published on February 1999

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

scientific article

Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival

scientific article published on 08 August 2019

Overcoming resistance to BRAF inhibitors.

scientific article published in October 2017

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.

scientific article published on August 2017

Phenotype plasticity as enabler of melanoma progression and therapy resistance

scientific article published on 17 June 2019

Receptor tyrosine kinase Xmrk mediates proliferation in Xiphophorus melanoma cells.

scientific article published on May 1998

STAT5 contributes to antiapoptosis in melanoma.

scientific article

STAT5 contributes to interferon resistance of melanoma cells.

scientific article published on September 2005

Signal transduction by the oncogenic receptor tyrosine kinase Xmrk in melanoma formation of Xiphophorus.

scientific article published on February 1997

Signalling by the oncogenic receptor tyrosine kinase Xmrk leads to activation of STAT5 in Xiphophorus melanoma.

scientific article published on June 1998

Spatial intra-tumour heterogeneity in acquired resistance to targeted therapy complicates the use of PDX models for co-clinical cancer studies.

scientific article published on 14 July 2015

TP53 in the UV spotlight: a bona fide driver of melanoma

scientific article published on 2 September 2014

Targeting MITF in the tolerance-phase

scientific article published on 18 May 2016

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

scientific article published on 12 June 2017

Targeting invasive properties of melanoma cells.

scientific article published on 14 February 2017

The Brn-2 transcription factor links activated BRAF to melanoma proliferation

scientific article

The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα

scientific article

The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells.

scientific article

The oncogenic epidermal growth factor receptor variant Xiphophorus melanoma receptor kinase induces motility in melanocytes by modulation of focal adhesions

scientific article published on 01 March 2006

Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells

scientific article published on 14 January 2014

V599EB-RAF is an oncogene in melanocytes

scientific article published on April 2004

Paulina is supported by:

About Paulina

Help