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List of works by Rodney A Lea

'Mutiny on the Bounty': the genetic history of Norfolk Island reveals extreme gender-biased admixture

scientific article

2D in-vivo L-COSY spectroscopy identifies neurometabolite alterations in treated multiple sclerosis

scientific article published on 19 October 2019

A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort

scientific article

A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers

scientific article

A comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?

scientific article

A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine.

scientific article published on 14 April 2005

A large-scale study of the relationship between blood and breath alcohol concentrations in New Zealand drinking drivers.

scientific article published in January 2006

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons.

scientific article

A randomized controlled trial of coenzyme Q10 for fatigue in the late-onset sequelae of poliomyelitis.

scientific article published on 9 September 2015

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.

scientific article published on 17 July 2015

A typical migraine susceptibility region localizes to chromosome 1q31

scientific article published on 01 March 2002

Accounting for cell lineage and sex effects in the identification of cell-specific DNA methylation using a Bayesian model selection algorithm

scientific article published on 28 September 2017

Allele frequency differences of cytochrome P450 polymorphisms in a sample of New Zealand Māori.

scientific article published on 18 April 2008

An Analysis of Clinical Characteristics in Genetically Linked Migraine-Affected Pedigrees

scientific article published in October 2003

An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss.

scientific article

An investigation of the 5-HT2C receptor gene as a migraine candidate gene.

scientific article

Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees.

scientific article published in September 2005

Analysis of the MTHFR C677T variant with migraine phenotypes.

scientific article

Anxiety Levels Are Independently Associated With Cognitive Performance in an Australian Multiple Sclerosis Patient Cohort.

scientific article published on 30 November 2016

Association between a 19 bp deletion polymorphism at the dopamine beta-hydroxylase (DBH) locus and migraine with aura.

scientific article published on 7 November 2006

Association of a GRIA3 gene polymorphism with migraine in an Australian case-control cohort.

scientific article published on 14 June 2013

Association of a vitamin D receptor polymorphism with sporadic breast cancer development

scientific article published on 10 December 1999

Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer

scientific article published in 2001

Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer

scientific article published on 14 February 2015

Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree.

scientific article

Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

scientific article published in January 2016

Association study of MTHFD1 coding polymorphisms R134K and R653Q with migraine susceptibility.

scientific article published on 18 July 2014

Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility

scientific article published in June 2007

Association study of calcitonin gene-related polypeptide-alpha (CALCA) gene polymorphism with migraine.

scientific article published on 31 December 2010

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Australian driving restrictions: how well do neurologists know them?

scientific article published on 01 September 2018

BDNF and TNF-α polymorphisms in memory.

scientific article published on 06 August 2013

Benzylpiperazine: a drug of abuse?

scientific article

Beta-actin--an unsuitable internal control for RT-PCR.

scientific article

Can a stress management programme reduce stress and improve quality of life in people diagnosed with multiple sclerosis?

scientific article published on 01 October 2018

Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma

scientific article

Children's untreated decay is positively associated with past caries experience and with current salivary loads of mutans Streptococci; negatively with self-reported maternal iron supplements during pregnancy: a multifactorial analysis

scientific article published on 14 December 2018

Comparison of genomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study.

scientific article published on 7 January 2012

Complete mitochondrial genome sequencing reveals novel haplotypes in a Polynesian population.

scientific article

Critical evaluation of linear regression models for cell-subtype specific methylation signal from mixed blood cell DNA

scientific article published in PLoS ONE

DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate.

scientific article published on 17 July 2018

Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.

scientific article

Diurnal stability and long-term repeatability of neurometabolites using single voxel 1H magnetic resonance spectroscopy

scientific article published on 17 September 2018

Diurnal variability of cerebral metabolites in healthy human brain with 2D localized correlation spectroscopy (2D L-COSY)

scientific article published on 10 January 2019

Dopamine receptor genes and migraine with and without aura: an association study.

scientific article published in May 2002

Effect of D1-like and D2-like receptor antagonists on methamphetamine and 3,4-methylenedioxymethamphetamine self-administration in rats.

scientific article published in December 2009

Effects of dietary folate intake on migraine disability and frequency

scientific article published on 19 January 2015

Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial

scientific article published on 24 March 2016

Epigenetics and migraine; complex mitochondrial interactions contributing to disease susceptibility

scientific article published on April 2014

Epigenome-wide association studies: current knowledge, strategies and recommendations

publication published on 04 December 2021

Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis.

scientific article published on 21 May 2018

European and Polynesian admixture in the Norfolk Island population.

scientific article

Exome Sequencing Diagnoses X-Linked Moesin-Associated Immunodeficiency in a Primary Immunodeficiency Case.

scientific article published on 5 March 2018

Expression QTL analysis of glaucoma endophenotypes in the Norfolk Island isolate provides evidence that immune-related genes are associated with optic disc size

scientific article published on 16 November 2017

Expression of glucocorticoid and progesterone nuclear receptor genes in archival breast cancer tissue

scientific article

Familial typical migraine: linkage to chromosome 19p13 and evidence for genetic heterogeneity.

scientific article published in May 1998

Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland.

scientific article

Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.

scientific article published on 17 January 2017

Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma

scientific article

Genetic association analysis of miRNA SNPs implicates MIR145 in breast cancer susceptibility.

scientific article published on 17 November 2015

Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine.

scientific article

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.

scientific article published on 24 January 2006

Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility.

scientific article published on 19 February 2005

Genetic variation in cytokine-related genes and migraine susceptibility

scientific article published on 20 September 2013

Genome-wide DNA methylation changes in CD19 B cells from relapsing-remitting multiple sclerosis patients

scientific article published in Scientific Reports

Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients

scientific article

Genome-wide allele-specific methylation is enriched at gene regulatory regions in a multi-generation pedigree from the Norfolk Island isolate

scientific article published on 08 October 2019

Genome-wide linkage and association analysis of primary open-angle glaucoma endophenotypes in the Norfolk Island isolate

scientific article published on 28 September 2017

Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation.

scientific article published in October 2012

Hand-rolled cigarette smoking patterns compared with factory-made cigarette smoking in New Zealand men

scientific article

Haplotype analysis at the alcohol dehydrogenase gene region in New Zealand Māori.

scientific article published on 19 December 2006

Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island.

scientific article published on 14 December 2011

Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma.

scientific article

In silico analyses reveal common cellular pathways affected by loss of heterozygosity (LOH) events in the lymphomagenesis of Non-Hodgkin's lymphoma (NHL).

scientific article

Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients

scientific article published in PLoS ONE

Investigating a Genetic Link Between Alzheimer’s Disease and CADASIL-Related Cerebral Small Vessel Disease

scientific article published in 2022

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population.

scientific article published in March 2004

Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population.

scientific article published in July 2004

Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility

scientific article

Investigation of homocysteine-pathway-related variants in essential hypertension.

scientific article

Investigation of hormone receptor genes in migraine.

scientific article published on 15 January 2005

Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals

scientific article published in November 2018

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine.

scientific article published in December 2004

Investigation of theCACNA1A gene as a candidate for typical migraine susceptibility

scientific article published on 8 December 2001

Ion torrent high throughput mitochondrial genome sequencing (HTMGS)

scientific article published on 15 November 2019

Legislation reduces exposure to second-hand tobacco smoke in New Zealand bars by about 90%.

scientific article published on August 2007

Letter to the editor: blood processing and sample storage have negligible effects on methylation.

scientific article published on 14 February 2018

Linkage disequilibrium analysis in the genetically isolated Norfolk Island population.

scientific article published on 19 December 2007

Linkage mapping of CVD risk traits in the isolated Norfolk Island population.

scientific article published on 31 October 2008

MTHFR and ACE Polymorphisms Do Not Increase Susceptibility to Migraine Neither Alone Nor in Combination.

scientific article published on 2 August 2016

Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits.

scientific article published on December 2013

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

scientific article

Methamphetamine self-administration and the effect of contingency on monoamine and metabolite tissue levels in the rat.

scientific article published on 3 December 2009

Methylation differences at the HLA-DRB1 locus in CD4+ T-Cells are associated with multiple sclerosis.

scientific article published on 12 December 2013

Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age.

scientific article

Molecular mechanisms of migraine: prospects for pharmacogenomics.

scientific article published on January 2003

Monoamine oxidase and tobacco dependence.

scientific article published on 21 July 2006

N-benzylpiperazine has characteristics of a drug of abuse.

scientific article published in December 2007

Natural killer cell subpopulations are associated with MRI activity in a relapsing-remitting multiple sclerosis patient cohort from Australia

scientific article published on 14 November 2016

Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells

scientific article published on 27 August 2016

Nicotinic receptors and stages of nicotine dependence.

scientific article published on 27 February 2009

No evidence for involvement of the human inducible nitric oxide synthase (iNOS) gene in susceptibility to typical migraine

scientific article published on 01 January 2001

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree

scientific article published in January 2006

No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility.

scientific article

Ongoing increase in incidence and prevalence of multiple sclerosis in Newcastle, Australia: A 50-year study

scientific article published on 28 September 2016

Parotid and cervical nodal status predict prognosis for patients with head and neck metastatic cutaneous squamous cell carcinoma

scientific article published on 01 August 2008

Parotid metastasis--an independent prognostic factor for head and neck cutaneous squamous cell carcinoma.

scientific article published on 5 June 2006

Pedigree derived mutation rate across the entire mitochondrial genome of the Norfolk Island population

scientific article published on 26 April 2022

Phenotypical characterisation of the isolated norfolk island population focusing on epidemiological indicators of cardiovascular disease.

scientific article published in January 2005

Post-traumatic stress disorder affects fucose-α(1-2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy

scientific article published on 18 January 2019

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma

scientific article published in September 2007

Prospects for whole genome linkage disequilibrium mapping in domestic dog breeds

scientific article published in September 2003

Protocol for assessing maternal, environmental and epigenetic risk factors for dental caries in children

scientific article

Reliability of neurometabolite detection with two-dimensional localized correlation spectroscopy at 3T.

scientific article published on 23 April 2018

Secondhand tobacco smoke exposure in New Zealand bars: results prior to implementation of the bar smoking ban

scientific article

Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate

scientific article published on 2 December 2015

Single Nucleotide Polymorphisms in Contribute to Protection Against Non-Hodgkin Lymphoma (NHL) in Caucasian Populations

article

Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.

scientific article published on December 2001

The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms.

scientific article

The NRP1 migraine risk variant shows evidence of association with menstrual migraine.

scientific article published on 18 April 2018

The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

scientific article published on 23 June 2016

The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability.

scientific article published in June 2009

The epidemiology of multiple sclerosis in New Zealand

scientific article published on 01 April 2005

The human μ-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a clinical cohort of female migraine with aura patients.

scientific article

The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in Caucasians.

scientific article

The null allele of GSTM1 does not affect susceptibility to solar keratoses in the Australian white population.

scientific article published in April 1998

The role of adenosine-related genes variants in susceptibility to essential hypertension.

scientific article published in August 2004

The role of vascular and hormonal genes in migraine susceptibility.

scientific article

The search for migraine genes: an overview of current knowledge.

scientific article published on February 2007

Tobacco particulate matter is more potent than nicotine at upregulating nicotinic receptors on SH-SY5Y cells.

scientific article

Understanding the immune responses to the meningococcal strain-specific vaccine MeNZB measured in studies of infants.

scientific article published on July 2006

Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene.

scientific article published on 16 May 2013

Variant Call Format-Diagnostic Annotation and Reporting Tool: A Customizable Analysis Pipeline for Identification of Clinically Relevant Genetic Variants in Next-Generation Sequencing Data

scientific article published on 20 August 2019

Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population.

scientific article published in January 2005

Within-subject variation of the salivary 3HC/COT ratio in regular daily smokers: prospects for estimating CYP2A6 enzyme activity in large-scale surveys of nicotine metabolic rate.

scientific article published in July 2006

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