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List of works by Susan M Schlenner

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

scientific article

A kindred with mutant IKAROS and autoimmunity.

scientific article published on 27 April 2018

A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.

scientific article published in March 2014

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

scientific article published on 01 April 2019

A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway.

scientific article

Abnormal differentiation of B cells and megakaryocytes in Roifman syndrome.

scientific article published on 29 January 2018

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice

scientific article published on 25 January 2017

Early T cell development and the pitfalls of potential.

scientific article published on 14 July 2010

Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus

scientific article published on 18 March 2010

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.

scientific article published on 11 February 2015

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

scientific article published on 21 March 2016

Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation

scientific article

Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin

scientific article published on 27 February 2007

Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation

scientific article

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

scientific article

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis.

scientific article published in December 2012

Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin

scientific article

NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology

scientific article published on 14 December 2018

Premature thymic involution is independent of structural plasticity of the thymic stroma.

scientific article

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells

scientific article published on 23 December 2014

Regulatory T cell differentiation: cooperation saves the day.

scientific article

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.

scientific article

The Long Non-coding RNA Anticipates Foxp3 Expression in Regulatory T Cells

scientific article published on 25 September 2018

The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.

scientific article

The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity

scientific article published on January 2016

The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages

scientific article published on 7 November 2014

The thymoprotective function of leptin is indirectly mediated via suppression of obesity.

scientific article published on 14 July 2015

Thymus-autonomous T cell development in the absence of progenitor import

scientific article

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