List of works - Alexander C.J. van Akkooi

(Near-Infrared) Fluorescence-Guided Surgery Under Ambient Light Conditions: A Next Step to Embedment of the Technology in Clinical Routine

scientific article published on 28 March 2016

Adjuvant Therapy for Melanoma: Past, Current, and Future Developments

scientific article published on 21 July 2020

An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma

scientific article published on 17 April 2019

Blue dye can be safely omitted in most sentinel node procedures for melanoma

scientific article published on 26 May 2016

Broadening indications for neoadjuvant immunotherapy

scientific article published on 03 February 2020

Challenges in sentinel node pathology in the era of adjuvant treatment

scientific article published on 29 June 2020

Clinical Prognostic Markers in Stage IIIB Melanoma.

scientific article

Clinical prognostic markers in stage IIIC melanoma

scientific article published on 15 April 2017

Clinical relevance of melanoma micrometastases (<0.1 mm) in sentinel nodes: are these nodes to be considered negative?

scientific article

Comment: Detailed Pathologic Examination of Completion Node Dissection Specimens and Outcome for Melanoma Patients with Minimal (< 0.1 mm) Sentinel Lymph Node Metastases.

scientific article published on 7 November 2017

Conditional survival of malignant melanoma in The Netherlands: 1994-2008.

scientific article

Cutaneous melanoma and sentinel lymph node biopsy.

scientific article published on 2 February 2008

Development and validation of a nomogram to predict recurrence and melanoma-specific mortality in patients with negative sentinel lymph nodes

article

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

scientific article published on 27 December 2018

EORTC Melanoma Group achievements

scientific article published in March 2012

EORTC Melanoma Group sentinel node protocol identifies high rate of submicrometastases according to Rotterdam Criteria.

scientific article published in September 2010

Effects of time interval between primary melanoma excision and sentinel node biopsy on positivity rate and survival.

scientific article published on 23 September 2016

Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma (MCC): A multicenter experience.

scientific article published on 03 August 2017

Erratum to: gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol

scientific article published on 30 May 2017

Extra-axial chordoma.

scientific article

Gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol.

scientific article

Gamma probe and ultrasound-guided fine needle aspiration cytology of the sentinel node (GULF) trial

scientific article published on 26 April 2018

Healthcare Costs of Metastatic Cutaneous Melanoma in the Era of Immunotherapeutic and Targeted Drugs

scientific article published on 18 April 2020

High response rates for T-VEC in early metastatic melanoma (stage IIIB/C-IVM1a)

scientific article published on 21 February 2019

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

scientific article published on 31 May 2019

Immediate completion lymph node dissection in stage IIIA melanoma does not provide significant additional staging information beyond EORTC SN tumour burden criteria.

scientific article published on 3 October 2017

Implementation of the 7th edition AJCC staging system: Effects on staging and survival for pT1 melanoma. A Dutch population based study

scientific article published on 20 January 2017

Improved stratification of pT1 melanoma according to the 8th American Joint Committee on Cancer staging edition criteria: A Dutch population-based study.

scientific article published on 4 December 2017

Increased sampling will lead to an increase in detection, but is it clinically relevant?

scientific article published on 13 June 2012

Isolated Limb Perfusion for Melanoma is Safe and Effective in Elderly Patients.

scientific article published on 10 February 2017

Isolated limb perfusion for locally advanced angiosarcoma in extremities: A multi-centre study.

scientific article published on 14 September 2017

Long-term results of ultrasound guided fine needle aspiration cytology in conjunction with sentinel node biopsy support step-wise approach in melanoma.

scientific article published on 21 February 2017

Lymph node ratio as a prognostic factor in melanoma: results from European Organization for Research and Treatment of Cancer 18871, 18952, and 18991 studies

scientific article published on 01 June 2018

Making Peace With Cancer.

scientific article published on 12 October 2015

Melanoma

scientific article published on 01 September 2018

Melanoma: MSLT-1--SNB is a biomarker, not a therapeutic intervention

scientific article published on 08 April 2014

Merkel cell carcinoma: Clinical outcome and prognostic factors in 351 patients

scientific article published on 22 May 2018

Molecular characterization and patient outcome of melanoma nodal metastases and an unknown primary site.

scientific article

Morbidity and prognosis after therapeutic lymph node dissections for malignant melanoma.

scientific article

Multimodality approach to the sentinel node: an algorithm for the use of presentinel lymph node biopsy ultrasound (after lymphoscintigraphy) in conjunction with presentinel lymph node biopsy fine needle aspiration cytology.

scientific article

Multivariable analysis comparing outcome after sentinel node biopsy or therapeutic lymph node dissection in patients with melanoma.

scientific article

Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium

scientific article published on 01 July 2019

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

scientific article published on 08 October 2018

Optimal extent of completion lymphadenectomy for patients with melanoma and a positive sentinel node in the groin

scientific article

Outcome after surgical treatment of dermatofibrosarcoma protuberans: Is clinical follow-up always indicated?

scientific article published on 15 January 2019

PET/CT surveillance detects asymptomatic recurrences in stage IIIB and IIIC melanoma patients: a prospective cohort study.

scientific article published on 20 February 2017

Parotidectomy in patients with head and neck cutaneous melanoma with cervical lymph node involvement

scientific article published on 14 February 2019

Pathological assessment of resection specimens after neoadjuvant therapy for metastatic melanoma

scientific article published on 01 August 2018

Pigmentation in the sentinel node correlates with increased sentinel node tumor burden in melanoma patients.

scientific article

Positron emission tomography/computed tomography evaluation of oncolytic virus therapy efficacy in melanoma

scientific article published on 7 December 2017

Practice-Changing Developments in Stage III Melanoma: Surgery, Adjuvant Targeted Therapy, and Immunotherapy

scientific article published on 01 May 2018

Pre-SN Ultrasound-FNAC can be Sensitive for Lymph Node Metastases in Melanoma Patients if Performed with the Use of the Berlin Criteria

scientific article published on 20 November 2017

Prognostic and predictive value of AJCC-8 staging in the phase III EORTC1325/KEYNOTE-054 trial of pembrolizumab vs placebo in resected high-risk stage III melanoma

scientific article published on 11 June 2019

Quality assurance in melanoma care: The EU-MELACARE study

scientific article published on 03 July 2018

Real-world healthcare costs of ipilimumab in patients with advanced cutaneous melanoma in The Netherlands

scientific article published on 01 July 2018

Real-world use, safety, and survival of ipilimumab in metastatic cutaneous melanoma in The Netherlands.

scientific article published on 13 April 2018

Recent article by T. Rettenbacher describing the use of ultrasound (US) for the assessment of peripheral lymph nodes (Rettenbacher T. Ultraschall in Med 2010; 31: 344 – 362)

scientific article published on 04 April 2011

Recent developments in lymph node surgery for melanoma

scientific article published on 01 January 2019

Remarkable effects of imatinib in a family with young onset gastrointestinal stromal tumors and cutaneous hyperpigmentation associated with a germline KIT-Trp557Arg mutation: case report and literature overview

scientific article published on 14 July 2017

Reply to "Current controversies on sentinel node biopsy in thin and thick cutaneous melanoma"

scientific article published on 05 November 2016

Reply to: Letter re: Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma: A multicenter experience

scientific article published on 16 February 2019

Response to Wheatley et al., "Surgical excision margins in primary cutaneous melanoma: A meta-analysis and Bayesian probability evaluation", Cancer Treatment Reviews.

scientific article published on 14 March 2016

Risk Factors for Positive Deep Pelvic Nodal Involvement in Patients with Palpable Groin Melanoma Metastases: Can the Extent of Surgery be Safely Minimized? : A Retrospective, Multicenter Cohort Study.

scientific article

Risk stratification of sentinel node-positive melanoma patients defines surgical management and adjuvant therapy treatment considerations.

scientific article published on 13 April 2018

Role of ultrasound in the assessment of the sentinel node of melanoma patients

scientific article published on 01 December 2010

Rotterdam Criteria for sentinel node (SN) tumor burden and the accuracy of ultrasound (US)-guided fine-needle aspiration cytology (FNAC): can US-guided FNAC replace SN staging in patients with melanoma?

scientific article published on 8 September 2009

SLNB in melanoma-DFS a true and cost-effective benefit?

scientific article published on 14 October 2014

Sentinel node biopsy in melanoma: Current controversies addressed.

scientific article

Sentinel node followed by completion lymph node dissection versus nodal observation: staging or therapeutic? Controversy continues despite final results of MSLT-1

scientific article published on 01 August 2014

Sonographic criteria for diagnosing sentinel node metastases in melanoma patients

scientific article

Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy

scientific article published on 07 May 2020

Surgery of primary melanomas.

scientific article

Surgical removal of the index node marked using magnetic seed localization to assess response to neoadjuvant immunotherapy in patients with stage III melanoma

scientific article published on 18 March 2019

The Diagnostic Value of PET/CT Imaging in Melanoma Groin Metastases

scientific article published on 26 February 2016

The Rotterdam criteria for sentinel node tumor load: the simplest prognostic factor?

scientific article published on 17 November 2008

The analysis of the outcomes and factors related to iliac-obturator involvement in cutaneous melanoma patients after lymph node dissection due to positive sentinel lymph node biopsy or clinically detected inguinal metastases.

scientific article published on 5 January 2013

The extent of surgery for stage III melanoma: how much is appropriate?

scientific article published on 01 March 2019

The great debate at "Melanoma Bridge 2018", Naples, December 1st, 2018.

scientific article published on 10 May 2019

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study.

scientific article published on 27 May 2016

The prognostic significance of sentinel node tumour burden in melanoma patients: an international, multicenter study of 1539 sentinel node-positive melanoma patients

scientific article

The use of FDG-PET/CT to detect early recurrence after resection of high-risk stage III melanoma

scientific article published on 11 August 2020

The value of preoperative ultrasound (after lymphoscintigraphy) in conjunction with pre-sentinel lymph node biopsy fine-needle aspiration outweighs the usage of ultrasound alone in conjunction with lymphoscintigraphy: the need for an algorithm.

scientific article published in August 2010

Therapeutic surgical management of palpable melanoma groin metastases: superficial or combined superficial and deep groin lymph node dissection.

scientific article

Time dependent dynamics of wound complications after preoperative radiotherapy in Extremity Soft Tissue Sarcomas

scientific article published on 06 October 2018

Timing of completion lymphadenectomy after positive sentinel node biopsy in patients with melanoma.

scientific article published on 20 February 2017

Treatment and survival of Merkel cell carcinoma since 1993: A population-based cohort study in The Netherlands

scientific article published on 29 January 2019

Treatment of melanoma of unknown primary in the era of immunotherapy and targeted therapy: A Dutch population-based study

scientific article published on 20 March 2019

Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity.

scientific article published on 12 February 2016

Unknown Primary Melanoma: Worldwide Survey on Clinical Management.

scientific article published on 5 January 2017

Validation of a Nomogram for Non-sentinel Node Positivity in Melanoma Patients, and Its Clinical Implications: A Brazilian-Dutch Study

scientific article published on 19 November 2018

Vemurafenib in BRAF-mutant metastatic melanoma patients in real-world clinical practice: prognostic factors associated with clinical outcomes

scientific article published on 01 August 2018

List of works by Alexander C.J. van Akkooi

(Near-Infrared) Fluorescence-Guided Surgery Under Ambient Light Conditions: A Next Step to Embedment of the Technology in Clinical Routine

Adjuvant Therapy for Melanoma: Past, Current, and Future Developments

An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma

Blue dye can be safely omitted in most sentinel node procedures for melanoma

Broadening indications for neoadjuvant immunotherapy

Challenges in sentinel node pathology in the era of adjuvant treatment

Clinical Prognostic Markers in Stage IIIB Melanoma.

Clinical prognostic markers in stage IIIC melanoma

Clinical relevance of melanoma micrometastases (<0.1 mm) in sentinel nodes: are these nodes to be considered negative?

Comment: Detailed Pathologic Examination of Completion Node Dissection Specimens and Outcome for Melanoma Patients with Minimal (< 0.1 mm) Sentinel Lymph Node Metastases.

Conditional survival of malignant melanoma in The Netherlands: 1994-2008.

Cutaneous melanoma and sentinel lymph node biopsy.

Development and validation of a nomogram to predict recurrence and melanoma-specific mortality in patients with negative sentinel lymph nodes

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

EORTC Melanoma Group achievements

EORTC Melanoma Group sentinel node protocol identifies high rate of submicrometastases according to Rotterdam Criteria.

Effects of time interval between primary melanoma excision and sentinel node biopsy on positivity rate and survival.

Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma (MCC): A multicenter experience.

Erratum to: gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol

Extra-axial chordoma.

Gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol.

Gamma probe and ultrasound-guided fine needle aspiration cytology of the sentinel node (GULF) trial

Healthcare Costs of Metastatic Cutaneous Melanoma in the Era of Immunotherapeutic and Targeted Drugs

High response rates for T-VEC in early metastatic melanoma (stage IIIB/C-IVM1a)

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

Immediate completion lymph node dissection in stage IIIA melanoma does not provide significant additional staging information beyond EORTC SN tumour burden criteria.

Implementation of the 7th edition AJCC staging system: Effects on staging and survival for pT1 melanoma. A Dutch population based study

Improved stratification of pT1 melanoma according to the 8th American Joint Committee on Cancer staging edition criteria: A Dutch population-based study.

Increased sampling will lead to an increase in detection, but is it clinically relevant?

Isolated Limb Perfusion for Melanoma is Safe and Effective in Elderly Patients.

Isolated limb perfusion for locally advanced angiosarcoma in extremities: A multi-centre study.

Long-term results of ultrasound guided fine needle aspiration cytology in conjunction with sentinel node biopsy support step-wise approach in melanoma.

Lymph node ratio as a prognostic factor in melanoma: results from European Organization for Research and Treatment of Cancer 18871, 18952, and 18991 studies

Making Peace With Cancer.

Melanoma

Melanoma: MSLT-1--SNB is a biomarker, not a therapeutic intervention

Merkel cell carcinoma: Clinical outcome and prognostic factors in 351 patients

Molecular characterization and patient outcome of melanoma nodal metastases and an unknown primary site.

Morbidity and prognosis after therapeutic lymph node dissections for malignant melanoma.

Multimodality approach to the sentinel node: an algorithm for the use of presentinel lymph node biopsy ultrasound (after lymphoscintigraphy) in conjunction with presentinel lymph node biopsy fine needle aspiration cytology.

Multivariable analysis comparing outcome after sentinel node biopsy or therapeutic lymph node dissection in patients with melanoma.

Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

Optimal extent of completion lymphadenectomy for patients with melanoma and a positive sentinel node in the groin

Outcome after surgical treatment of dermatofibrosarcoma protuberans: Is clinical follow-up always indicated?

PET/CT surveillance detects asymptomatic recurrences in stage IIIB and IIIC melanoma patients: a prospective cohort study.

Parotidectomy in patients with head and neck cutaneous melanoma with cervical lymph node involvement

Pathological assessment of resection specimens after neoadjuvant therapy for metastatic melanoma

Pigmentation in the sentinel node correlates with increased sentinel node tumor burden in melanoma patients.

Positron emission tomography/computed tomography evaluation of oncolytic virus therapy efficacy in melanoma

Practice-Changing Developments in Stage III Melanoma: Surgery, Adjuvant Targeted Therapy, and Immunotherapy

Pre-SN Ultrasound-FNAC can be Sensitive for Lymph Node Metastases in Melanoma Patients if Performed with the Use of the Berlin Criteria

Prognostic and predictive value of AJCC-8 staging in the phase III EORTC1325/KEYNOTE-054 trial of pembrolizumab vs placebo in resected high-risk stage III melanoma

Quality assurance in melanoma care: The EU-MELACARE study

Real-world healthcare costs of ipilimumab in patients with advanced cutaneous melanoma in The Netherlands

Real-world use, safety, and survival of ipilimumab in metastatic cutaneous melanoma in The Netherlands.

Recent article by T. Rettenbacher describing the use of ultrasound (US) for the assessment of peripheral lymph nodes (Rettenbacher T. Ultraschall in Med 2010; 31: 344 – 362)

Recent developments in lymph node surgery for melanoma

Remarkable effects of imatinib in a family with young onset gastrointestinal stromal tumors and cutaneous hyperpigmentation associated with a germline KIT-Trp557Arg mutation: case report and literature overview

Reply to "Current controversies on sentinel node biopsy in thin and thick cutaneous melanoma"

Reply to: Letter re: Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma: A multicenter experience

Response to Wheatley et al., "Surgical excision margins in primary cutaneous melanoma: A meta-analysis and Bayesian probability evaluation", Cancer Treatment Reviews.

Risk Factors for Positive Deep Pelvic Nodal Involvement in Patients with Palpable Groin Melanoma Metastases: Can the Extent of Surgery be Safely Minimized? : A Retrospective, Multicenter Cohort Study.

Risk stratification of sentinel node-positive melanoma patients defines surgical management and adjuvant therapy treatment considerations.

Role of ultrasound in the assessment of the sentinel node of melanoma patients

Rotterdam Criteria for sentinel node (SN) tumor burden and the accuracy of ultrasound (US)-guided fine-needle aspiration cytology (FNAC): can US-guided FNAC replace SN staging in patients with melanoma?

SLNB in melanoma-DFS a true and cost-effective benefit?

Sentinel node biopsy in melanoma: Current controversies addressed.

Sentinel node followed by completion lymph node dissection versus nodal observation: staging or therapeutic? Controversy continues despite final results of MSLT-1

Sonographic criteria for diagnosing sentinel node metastases in melanoma patients

Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy

Surgery of primary melanomas.

Surgical removal of the index node marked using magnetic seed localization to assess response to neoadjuvant immunotherapy in patients with stage III melanoma

The Diagnostic Value of PET/CT Imaging in Melanoma Groin Metastases

The Rotterdam criteria for sentinel node tumor load: the simplest prognostic factor?

The analysis of the outcomes and factors related to iliac-obturator involvement in cutaneous melanoma patients after lymph node dissection due to positive sentinel lymph node biopsy or clinically detected inguinal metastases.

The extent of surgery for stage III melanoma: how much is appropriate?

The great debate at "Melanoma Bridge 2018", Naples, December 1st, 2018.

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study.