Search filters

List of works by Bruce J Brew

A Screening Strategy for HIV-Associated Neurocognitive Disorders That Accurately Identifies Patients Requiring Neurological Review.

scientific article published on 19 June 2016

A new era in the treatment of multiple sclerosis

scientific article (publication date: 3 August 2015)

A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy

scientific article published on 01 February 2012

A report on the effect of commencing enfuvirtide on peripheral neuropathy.

scientific article published in August 2008

A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes

scientific article published on 04 June 2013

AIDS dementia complex

scientific article published on 01 January 2007

APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals - a cross-sectional observational study

scientific article

Additive and Synergistic Cardiovascular Disease Risk Factors and HIV Disease Markers' Effects on White Matter Microstructure in Virally Suppressed HIV

scientific article published on 01 August 2020

Amyloid and tau cerebrospinal fluid biomarkers in HIV infection

scientific article

An examination of reliable change methods for measuring cognitive change with the Cogstate Computerized Battery: Research and clinical implications

scientific article published on 10 October 2020

Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV

scientific article published in 2021

Atrophic brain signatures of mild forms of neurocognitive impairment in virally suppressed HIV infection

article

Axonal excitability in viral polyneuropathy and nucleoside neuropathy in HIV patients

scientific article published on 16 July 2010

Bcl11b-A Critical Neurodevelopmental Transcription Factor-Roles in Health and Disease.

scientific article

Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?

scientific article

Benefit or toxicity from neurologically targeted antiretroviral therapy?

scientific article published in March 2010

Biomarkers of HIV related central nervous system disease

scientific article published on February 2008

Blood-brain barrier integrity, intrathecal immunoactivation, and neuronal injury in HIV.

scientific article

CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

scientific article published on 25 August 2015

CSF neurofilament protein (NFL) -- a marker of active HIV-related neurodegeneration.

scientific article published on 10 April 2007

Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons.

scientific article

Central nervous system antiretroviral efficacy in HIV infection: a qualitative and quantitative review and implications for future research

scientific article

Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden

scientific article published in September 2011

Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary HIV infection

scientific article published on 4 March 2013

Cerebrospinal fluid markers in central nervous system HIV infection and AIDS dementia complex

scientific article published on 01 January 2007

Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection

scientific article

Cerebrovascular disease in HIV-infected individuals in the era of highly active antiretroviral therapy

scientific article published on 14 April 2012

Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons

scientific article published on 16 May 2014

Characterisation of the expression of NMDA receptors in human astrocytes

scientific article (publication date: 2010)

Characterization of the Kynurenine Pathway in CD8+ Human Primary Monocyte-Derived Dendritic Cells.

scientific article

Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages.

scientific article published on 15 May 2013

Characterization of the kynurenine pathway in human neurons

scientific article published on November 2007

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing.

scientific article

Cognitive ageing is premature among a community sample of optimally treated people living with HIV

scientific article published on 21 October 2020

Cognitive change trajectories in virally suppressed HIV-infected individuals indicate high prevalence of disease activity

scientific article

Cognitive function, mood and health-related quality of life in hepatitis C virus (HCV)-monoinfected and HIV/HCV-coinfected individuals commencing HCV treatment.

scientific article published in April 2007

Comorbid depression and apathy in HIV-associated neurocognitive disorders in the era of chronic HIV infection

scientific article published on 01 January 2019

Consensus guidelines for the investigation and management of encephalitis

scientific article published on 01 June 2015

Consensus guidelines for the investigation and management of encephalitis in adults and children in Australia and New Zealand.

scientific article published on May 2015

Correction: The Kynurenine Pathway in Brain Tumor Pathogenesis

scientific article published on 7 December 2012

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau

scientific article published on 01 April 2019

Could antiretroviral drugs be effective in multiple sclerosis? A case report ⬇️

scientific article published on September 1, 2011

Covertly active and progressing neurochemical abnormalities in suppressed HIV infection.

scientific article published on 3 January 2018

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

scientific article

Defining and evaluating HIV-related neurodegenerative disease and its treatment targets: a combinatorial approach to use of cerebrospinal fluid molecular biomarkers

scientific article published on 12 September 2006

Determining optimal impairment rating methodology for a new HIV-associated neurocognitive disorder screening procedure

scientific article published on 4 January 2017

Differential expression of CD163 on monocyte subsets in healthy and HIV-1 infected individuals.

scientific article

Does HIV prematurely age the brain?

scientific article

Does use of antiretroviral therapy regimens with high central nervous system penetration improve survival in HIV-infected adults?

scientific article published on 7 August 2011

Editorial: HIV-1 infection and the nervous system: a shifting target.

scientific article published in November 2014

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease.

scientific article published on 10 December 2009

Effect of the Mediterranean diet on cognition and brain morphology and function: a systematic review of randomized controlled trials.

scientific article published in March 2018

Effectiveness of the progestin-only pill for migraine treatment in women: A systematic review and meta-analysis

scientific article published on January 2017

Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons.

scientific article published on 03 April 2009

Elevated cerebrospinal fluid neurofilament light protein concentrations predict the development of AIDS dementia complex

scientific article published on 02 May 2007

Epilepsy: Issues with antiepileptic drug use in HIV-infected patients

scientific article published on 13 March 2012

Erratum to: An examination of reliable change methods for measuring cognitive change with the Cogstate Computerized Battery: Research and clinical implications

scientific article published on 28 December 2020

Erratum to: White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration.

scientific article published on 28 July 2017

Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex

scientific article published on January 2004

Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia

scientific article

Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation

scientific article (publication date: March 2003)

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

scientific article

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease

scientific article published on 26 June 2015

Expression of the kynurenine pathway enzymes in human microglia and macrophages

scientific article

Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain

scientific article

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

scientific article published in August 2009

Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial

scientific article

First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia.

scientific article

Functional Connectivity in Virally Suppressed Patients with HIV-Associated Neurocognitive Disorder: A Resting-State Analysis

scientific article published on 8 June 2017

Global NeuroAIDS roundtable

scientific article published on 26 January 2013

HAD and the need for new trial design methodology

scientific article published on 01 September 2007

HIV and age do not substantially interact in HIV-associated neurocognitive impairment.

scientific article published in January 2011

HIV associated neurocognitive disorders in the modern antiviral treatment era: prevalence, characteristics, biomarkers, and effects of treatment.

scientific article published on September 2014

HIV brain latency as measured by CSF BcL11b relates to disrupted brain cellular energy in virally suppressed HIV infection

scientific article published on 01 March 2019

HIV eradication symposium: will the brain be left behind?

scientific article published on 7 March 2015

HIV, HAART, and Parkinson's disease: co-incidence or pathogenetic link?

scientific article published on 01 October 2010

HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau

article

HIV, vascular and aging injuries in the brain of clinically stable HIV-infected adults: a (1)H MRS study

scientific article

HIV-associated dementia: an inconvenient truth

scientific article published on 01 January 2007

HIV-associated neurocognitive disorder

article

HIV-associated neurocognitive disorder in Australia: a case of a high-functioning and optimally treated cohort and implications for international neuroHIV research

scientific article

HIV-associated neurocognitive disorders: is there a hidden epidemic?

scientific article published on 01 June 2010

HIV-associated neurocognitive disorders: recent advances in pathogenesis, biomarkers, and treatment.

scientific article published on 23 March 2017

Has HIV-associated neurocognitive disorders now transformed into vascular cognitive impairment?

scientific article published on 01 September 2016

Hepatitis C seropositivity is not a risk factor for sensory neuropathy among patients with HIV.

scientific article

High-risk coronary plaque, invasive coronary procedures, and cardiac events among HIV-positive individuals and matched controls.

scientific article

Human Immunodeficiency Virus and the Nervous System

scientific article published on 01 November 2018

Human immunodeficiency virus-associated progressive multifocal leucoencephalopathy: epidemiology and predictive factors for prolonged survival.

scientific article published on April 2007

Human immunodeficiency virus-related primary central nervous system lymphoma: factors influencing survival in 111 patients.

scientific article published on June 2004

Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and Copaxone

scientific article published on 01 January 2007

Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis.

scientific article published on January 2005

Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease

scientific article

Improved neurocognitive test performance in both arms of the SMART study: impact of practice effect.

scientific article published on 14 August 2013

Incidence and prevalence of NMOSD in Australia and New Zealand.

scientific article published on 26 May 2017

Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment

scientific article published on September 2004

Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus

scientific article

Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO).

scientific article

Interventions for Neurocognitive Dysfunction

scientific article published on 21 January 2017

Introduction to HIV infection and HIV neurology

scientific article published on 01 January 2018

Involvement of quinolinic acid in AIDS dementia complex

scientific article

Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.

scientific article published on 2 June 2016

Involvement of the kynurenine pathway in human glioma pathophysiology

scientific article

Is There Any Evidence of Premature, Accentuated and Accelerated Aging Effects on Neurocognition in People Living with HIV? A Systematic Review

scientific article published on 06 October 2020

Is specific HIV eradication from the brain possible or needed?

scientific article published on 05 January 2013

Is the HIV Dementia Scale a Reliable Tool for Assessing HIV-related Neurocognitive Decline?

article

Kaposi sarcoma in a fingolimod-treated patient with multiple sclerosis.

scientific article

Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity.

scientific article published on 21 January 2008

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

scientific article published on 03 February 2017

Lead dysregulates serine/threonine protein phosphatases in human neurons.

scientific article

Lost in translation: again, another failed neuroprotection trial.

scientific article published in September 2007

Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder.

scientific article published on February 2016

Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not

Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons.

scientific article

Meta-analysis of magnetic resonance spectroscopy in the diagnosis of hepatic encephalopathy

scientific article published on 09 January 2020

Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification ⬇️

scientific article published on November 11, 2003

Monitoring HIV-Associated Neurocognitive Disorder Using Screenings: a Critical Review Including Guidelines for Clinical and Research Use.

scientific article published on 10 March 2017

Myasthenia gravis exacerbation with low dose ocular botulinum toxin for epiphoria

scientific article published on 15 July 2015

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials

scientific article published on 28 January 2013

Natalizumab-associated PML identified in the presymptomatic phase using MRI surveillance

scientific article published on 01 February 2012

Neural transplantation of human MSC and NT2 cells in the twitcher mouse model.

scientific article published on January 2006

NeuroAIDS in the Asia Pacific Region

scientific article published in November 2008

Neurocognitive dysfunction in the highly active antiretroviral therapy era.

scientific article published on February 2012

Neurodegeneration and ageing in the HAART era.

scientific article published on 06 December 2008

Neurologic sequelae of primary HIV infection

article

Neurological Complications in Controlled HIV Infection.

scientific article published on December 2013

Neurological complications of HIV infection.

scientific article

Neurological sequelae of primary HIV infection

scientific article published on 01 January 2007

Neuropsychological functioning and antiretroviral treatment in HIV/AIDS: a review.

scientific article published on 09 May 2009

No Neurocognitive Advantage for Immediate Antiretroviral Treatment in adults with greater than 500 CD4+ T Cell Counts.

scientific article published on 8 February 2018

Parkinsonism in hiv-infected patients on highly active antiretroviral therapy.

scientific article published in August 2009

Participants' perspectives of high resolution anoscopy

scientific article published on 01 June 2011

Participants' perspectives of self-collected anal cytological swabs

scientific article published on 01 June 2011

Pathogenesis and diagnosis of viral infections of the nervous system.

scientific article

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

scientific article

Peripheral blood mononuclear cells HIV DNA levels impact intermittently on neurocognition

scientific article

Possible JCV granular cell neuronopathy in a patient with HIV infection

scientific article published on 01 November 2009

Posterior reversible encephalopathy syndrome (PRES) in an HIV-1 infected patient with disseminated varicella zoster virus: a case report

scientific article

Preface

Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: a combined study of two cohorts.

scientific article

Prevalence of non-confounded HIV-associated neurocognitive impairment in the context of plasma HIV RNA suppression.

scientific article published on 17 March 2011

Progressive multifocal leukoencephalopathy

scientific article published on 01 January 2018

Progressive multifocal leukoencephalopathy and other forms of JC virus disease

scientific article

Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex.

scientific article

Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies

scientific article

Raltegravir resistance in the cerebrospinal fluid ⬇️

scientific article published on February 3, 2013

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases.

scientific article published on 16 March 2016

Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals.

scientific article published on 04 January 2016

Role of the Kynurenine Pathway in Stem Cell Biology

scientific article published in 2015

Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT(1A) receptors

scientific article published on 10 March 2008

Short Communication: Do Cytomegalovirus Antibody Levels Associate with Age-Related Syndromes in HIV Patients Stable on Antiretroviral Therapy?

scientific article

Simultaneous classification and feature selection via convex quadratic programming with application to HIV-associated neurocognitive disorder assessment

article

Statistical integration of 1H NMR and MRS data from different biofluids and tissues enhances recovery of biological information from individuals with HIV-1 infection

scientific article

Strategies to target HIV-1 in the central nervous system.

scientific article published on 2 March 2016

Symptoms of depression and rates of neurocognitive impairment in HIV positive patients in Beijing, China.

scientific article published on 31 March 2014

The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes

scientific article

The Potential of the CNS as a Reservoir for HIV-1 Infection: Implications for HIV Eradication.

scientific article published on June 2015

The assessment of cognitive function in advanced HIV-1 infection and AIDS dementia complex using a new computerised cognitive test battery.

scientific article published on 15 December 2005

The burden of HIV-associated neurocognitive impairment in Australia and its estimates for the future.

scientific article published on December 2011

The effects of HIV and aging on brain functions: proposing a research framework and update on last 3 years' findings

scientific article published on July 2014

The excitotoxin quinolinic acid induces tau phosphorylation in human neurons

scientific article published on 22 July 2009

The high frequency of autoantibodies in HIV patients declines on antiretroviral therapy.

scientific article published on 17 February 2018

The involvement of astrocytes and kynurenine pathway in Alzheimer's disease.

scientific article published on December 2007

The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.

scientific article

The kynurenine pathway in brain tumor pathogenesis.

scientific article

The kynurenine pathway in stem cell biology.

scientific article published on 15 September 2013

The neuropsychological profile of symptomatic AIDS and ADC patients in the pre-HAART era: a meta-analysis

scientific article published in May 2006

The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia.

scientific article published on 8 July 2008

The role of depression chronicity and recurrence on neurocognitive dysfunctions in HIV-infected adults.

scientific article published on 25 August 2015

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 1 historical and established therapies. MS Neurology Group of the Australian and New Zealand Association of Neurolo

scientific article published on 30 June 2014

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 2 new and emerging therapies and their efficacy. MS Neurology Group of the Australian and New Zealand Association o

scientific article

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 3 treatment practicalities and recommendations. MS Neurology Group of the Australian and New Zealand Association of

scientific article published on 30 June 2014

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain

scientific article published on 25 March 2009

Transcriptional activity of blood-and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia

scientific article published in June 2006

Treatment of opportunistic infections and lymphoma in the nervous system

scientific article

Treatment of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome with intravenous immunoglobulin in a patient with multiple sclerosis treated with fingolimod after discontinuation of natalizumab.

scientific article published on 15 December 2014

Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder ⬇️

scientific article published on June 10, 2010

Understanding the roles of the kynurenine pathway in multiple sclerosis progression.

scientific article published on 25 August 2010

Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients

scientific article published in August 2005

Undifferentiated mouse mesenchymal stem cells spontaneously express neural and stem cell markers Oct-4 and Rex-1.

scientific article

Update on HIV dementia and HIV-associated neurocognitive disorders

scientific article

Updated research nosology for HIV-associated neurocognitive disorders

scientific article published on 3 October 2007

Validity of cognitive screens for HIV-associated neurocognitive disorder: a systematic review and an informed screen selection guide

scientific article published on December 2013

Valproic acid is associated with cognitive decline in HIV-infected individuals: a clinical observational study.

scientific article published on 6 December 2006

Variable benefit in neuropsychological function in HIV-infected HAART-treated patients.

scientific article

Vascular cognitive impairment and HIV-associated neurocognitive disorder: a new paradigm

scientific article published on 11 January 2019

Vestibular symptoms as the presenting feature of progressive supranuclear palsy.

scientific article published on 2 February 2018

White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration

scientific article published on 21 March 2017

Paulina is supported by:

About Paulina

Help