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List of works by Michael Grocott

'Blood doping' from Armstrong to prehabilitation: manipulation of blood to improve performance in athletes and physiological reserve in patients

scientific article

A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations.

scientific article published in January 2004

A national quality improvement programme to improve survival after emergency abdominal surgery: the EPOCH stepped-wedge cluster RCT

scientific article published on 3 October 2019

A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment

scientific article published on 24 June 2018

ASA scores in the preoperative patient: feedback to clinicians can improve data quality

scientific article published on 01 April 2007

Abnormal blood flow in the sublingual microcirculation at high altitude.

scientific article published on 31 March 2009

Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome.

scientific article

Acclimatization of skeletal muscle mitochondria to high‐altitude hypoxia during an ascent of Everest ⬇️

scientific article published on December 20, 2011

Acute high-altitude illness: a clinically orientated review

scientific article

Acute respiratory distress syndrome and acute lung injury ⬇️

scientific article published on 04 June 2011

American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Patient-Reported Outcomes in an Enhanced Recovery Pathway.

scientific article published on 29 December 2017

Anesthetists (and Physicians) at Altitude

scientific article published on 01 January 2018

Angiotensin-converting enzyme genotype and successful ascent to extreme high altitude

scientific article published on 01 January 2007

Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study

scientific article published on 01 June 2018

Association between preoperative haemoglobin concentration and cardiopulmonary exercise variables: a multicentre study.

scientific article published on 13 September 2013

Call for consensus on terminology and consistent clinical pathways in relation to anaemia in perioperative patients

scientific article published on 01 May 2016

Cardiopulmonary exercise testing

scientific article published on 26 December 2012

Cardiopulmonary exercise testing for risk prediction in major abdominal surgery.

scientific article

Cardiopulmonary exercise testing for the evaluation of perioperative risk in non-cardiopulmonary surgery.

scientific article published on 21 June 2011

Cardiopulmonary exercise testing for the prediction of morbidity risk after rectal cancer surgery.

scientific article published on 11 June 2014

Cardiopulmonary exercise testing predicts 5 yr survival after major surgery.

scientific article published on 21 August 2012

Cardiopulmonary exercise testing predicts postoperative outcome in patients undergoing gastric bypass surgery

scientific article published on 18 July 2012

Cardiopulmonary exercise testing, prehabilitation, and Enhanced Recovery After Surgery (ERAS)

scientific article

Cardiopulmonary exercise variables are associated with postoperative morbidity after major colonic surgery: a prospective blinded observational study.

scientific article published on 8 December 2013

Caudwell Xtreme Everest: A prospective study of the effects of environmental hypoxia on cognitive functioning

scientific article

Caudwell Xtreme Everest: An Overview

scientific article published on January 2016

Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation.

scientific article published on 18 March 2015

Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m).

scientific article published on 8 April 2017

Changes in muscle proteomics in the course of the Caudwell Research Expedition to Mt. Everest

scientific article published on 4 December 2014

Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude.

scientific article

Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude.

scientific article

Chronic kidney disease and postoperative morbidity after elective orthopedic surgery.

scientific article published on 31 August 2010

Citrated blood does not reliably reflect fresh whole blood coagulability in trials of in vitro hemodilution.

scientific article published in January 2003

Clinical review: Evidence-based perioperative medicine?

scientific article

Clinical review: Exogenous surfactant therapy for acute lung injury/acute respiratory distress syndrome--where do we go from here?

scientific article published on 22 November 2012

Coagulation effects of in vitro serial haemodilution with a balanced electrolyte hetastarch solution compared with a saline-based hetastarch solution and lactated Ringer's solution.

scientific article published in October 2002

Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery

scientific article

Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery.

scientific article published on 15 June 2017

Comparison of P-POSSUM risk-adjusted mortality rates after surgery between patients in the USA and the UK.

scientific article published in December 2003

Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial.

scientific article

Correction to: Intraoperative oxygenation in adult patients undergoing surgery (iOPS): a retrospective observational study across 29 UK hospitals

scientific article published on 24 October 2018

Critical care at the end of life: balancing technology with compassion and agreeing when to stop

scientific article published in December 2017

Current research priorities in perioperative intensive care medicine.

scientific article published on 08 June 2017

Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude

scientific article

Design and conduct of Xtreme Everest 2: An observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia.

scientific article

Development and internal validation of a novel risk adjustment model for adult patients undergoing emergency laparotomy surgery: the National Emergency Laparotomy Audit risk model

scientific article published on 23 August 2018

Differences between patients' and clinicians' research priorities from the Anaesthesia and Peri-operative Care Priority Setting Partnership.

scientific article

Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition

scientific article

Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study.

scientific article

Effects of dietary nitrate on respiratory physiology at high altitude - Results from the Xtreme Alps study.

scientific article published on 14 October 2017

Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude - A randomised controlled trial (Xtreme Alps)

scientific article published on 08 October 2019

Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp.

scientific article

Effects of five preoperative cardiovascular drugs on mortality after coronary artery bypass surgery: A retrospective analysis of an observational study of 16, 192 patients

scientific article published on 12 November 2015

Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation

scientific article

Enhanced recovery from surgery in the UK: an audit of the enhanced recovery partnership programme 2009-2012.

scientific article published on 29 April 2015

Enhanced recovery pathways as a way to reduce surgical morbidity ⬇️

scientific article published on August 1, 2012

Everest 60 years on: what next?

scientific article published on 6 June 2013

Exercise Testing, Supplemental Oxygen, and Hypoxia.

scientific article

Exercise and Nutrition Prehabilitation for the Evaluation of Risk and Therapeutic Potential in Cancer Patients: A Review

scientific article published on January 2016

Exercise intervention in people with cancer undergoing adjuvant cancer treatment following surgery: A systematic review.

scientific article published on 29 August 2015

Exercise intervention in people with cancer undergoing neoadjuvant cancer treatment and surgery: A systematic review.

scientific article published on 23 October 2015

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery

scientific article published on 11 December 2018

Exercise rehabilitation following intensive care unit discharge for recovery from critical illness

scientific article published on 22 June 2015

Exercise-Induced Systemic Venous Hypertension in the Fontan Circulation ⬇️

scientific article published on 3 March 2016

Exogenous surfactant therapy in acute lung injury/acute respiratory distress syndrome: the need for a revised paradigm approach

scientific article published on 19 April 2012

Extreme Physiology & Medicine: a new journal focussed on integrative human physiology under stress

scientific article

Facing acute hypoxia: from the mountains to critical care medicine

scientific article published in March 2017

Fit for surgery? Perspectives on preoperative exercise testing and training.

scientific article published in December 2017

From NELA to EPOCH and beyond: enhancing the evidence base for emergency laparotomy

scientific article published on September 2016

Genetic factors associated with exercise performance in atmospheric hypoxia

scientific article

Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia

scientific article published on 8 June 2017

High-risk surgery: epidemiology and outcomes.

scientific article published on 21 May 2010

Human physiology in extreme environments: lessons from life at the limits?

scientific article published on 01 January 2008

III. Oxygen therapy in anaesthesia: the yin and yang of O2.

scientific article published in December 2013

Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis

scientific article

Improving outcomes after surgery

scientific article published on 10 December 2009

In reply

Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry

scientific article published on 01 January 2007

Integrative physiology and systems biology: reductionism, emergence and causality.

scientific article published on 22 March 2013

Inter-observer reliability of preoperative cardiopulmonary exercise test interpretation: a cross-sectional study

scientific article published on 29 November 2017

Intraoperative oxygenation in adult patients undergoing surgery (iOPS): a retrospective observational study across 29 UK hospitals

scientific article published on 24 July 2018

Isolated generalized tonic-clonic seizure at high altitude in a young male trekker with a positive family history of seizure

scientific article published on 21 February 2014

Just scratching the surface: varied coagulation effects of polymer containers on TEG variables

scientific article published on 01 January 2006

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.

scientific article published on 16 May 2017

Ketamine for emergency anaesthesia at very high altitude (4243 m above sea-level).

scientific article

King of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude

scientific article

Losing concentration: time for a new MAPP?

scientific article published on 21 May 2015

Major elective joint replacement surgery: socioeconomic variations in surgical risk, postoperative morbidity and length of stay

scientific article published on 18 February 2010

Managing perioperative risk in patients undergoing elective non-cardiac surgery

scientific article published in the British Medical Journal

Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery

scientific article published on 11 March 2016

Metabolic adjustment to high-altitude hypoxia: from genetic signals to physiological implications

scientific article published on 20 April 2018

Metabolic basis to Sherpa altitude adaptation

scientific article

Metabolic monitoring in the intensive care unit: a comparison of the Medgraphics Ultima, Deltatrac II, and Douglas bag collection methods

scientific article

Mortality of emergency general surgical patients and associations with hospital structures and processes

scientific article

Mountainside to bedside: reality or fiction?

scientific article published on 01 December 2009

Muscle mass and physical recovery in ICU: innovations for targeting of nutrition and exercise

scientific article

National Research Strategies: what outcomes are important in peri-operative elderly care?

scientific article published on January 2014

National audits in the UK: fancy acronyms or real patient benefit?

scientific article published in April 2017

Organisational factors and mortality after an emergency laparotomy: multilevel analysis of 39 903 National Emergency Laparotomy Audit patients

scientific article published on 03 October 2018

Oxygen therapy and anaesthesia: too much of a good thing?

scientific article published in May 2015

Oxygen therapy and the Goldilocks principle

scientific article published on 26 October 2017

Parent stress levels during children's hospital recovery after congenital heart surgery

scientific article published on 22 May 2010

Patient optimisation before surgery: a clear and present challenge in peri-operative care

scientific article published on 01 January 2019

Patient-satisfaction measures in anesthesia: qualitative systematic review.

scientific article published on August 2013

Patients' perceptions of quality of life during active treatment for locally advanced rectal cancer: the importance of preoperative exercise ⬇️

scientific article published on August 3, 2013

Perceptions of diagnosis and management of patients with acute respiratory distress syndrome: a survey of United Kingdom intensive care physicians.

scientific article

Peri-operative care pathways: re-engineering care to achieve the 'triple aim'

scientific article published on 01 January 2019

Perioperative Medicine: The Value Proposition for Anesthesia?: A UK Perspective on Delivering Value from Anesthesiology.

scientific article published on December 2015

Perioperative administration of buffered versus non-buffered crystalloid intravenous fluid to improve outcomes following adult surgical procedures.

scientific article published on 21 September 2017

Perioperative administration of buffered versus non-buffered crystalloid intravenous fluid to improve outcomes following adult surgical procedures: a Cochrane systematic review

scientific article published on 13 December 2018

Perioperative buffered versus non-buffered fluid administration for surgery in adults

scientific article

Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation.

scientific article published on 24 November 2017

Perioperative cardiopulmonary exercise testing in the elderly.

scientific article published on September 2011

Perioperative exercise training in elderly subjects.

scientific article

Perioperative increase in global blood flow to explicit defined goals and outcomes after surgery: a Cochrane Systematic Review ⬇️

scientific article published on 09 May 2013

Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery

scientific article (published 2012-11-14)

Perioperative structure and process quality and safety indicators: a systematic review

scientific article published on 24 November 2017

Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients

scientific article

Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers.

scientific article published on February 2014

Physical activity levels in locally advanced rectal cancer patients following neoadjuvant chemoradiotherapy and an exercise training programme before surgery: a pilot study.

scientific article published on 16 February 2017

Physiology, pharmacology, and rationale for colloid administration for the maintenance of effective hemodynamic stability in critically ill patients.

scientific article

Plasma exchange in the management of a case of hypertriglyceridaemic pancreatitis triggered by venlafaxine ⬇️

scientific article published on August 14, 2012

Preoperative abnormalities in serum sodium concentrations are associated with higher in-hospital mortality in patients undergoing major surgery.

scientific article published on January 2016

Preoperative aerobic exercise training in elective intra-cavity surgery: a systematic review

scientific article

Preparing the patient for surgery to improve outcomes

scientific article

Prognostic studies of perioperative risk: robust methodology is needed.

scientific article published on September 2010

Protocol for a randomised pilot multiple centre trial of conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU).

scientific article published on 14 December 2017

Pupil Dynamics in Hypoxic Conditions: Caudwell Xtreme Everest Results

scientific article published on 11 September 2014

Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics?

scientific article published on 22 January 2019

Quality of reporting in randomized trials published in high-quality surgical journals.

scientific article published on 11 September 2009

Re-designing the pathway to surgery: better care and added value

scientific article

Recommendations for perioperative oxygenation

scientific article published on 01 November 2015

Reduced coagulation at high altitude identified by thromboelastography ⬇️

scientific article published on March 22, 2012

Replicating measurements of total hemoglobin mass (tHb-mass) within a single day: precision of measurement; feasibility and safety of using oxygen to expedite carbon monoxide clearance

scientific article published on 01 September 2018

Reply from the authors

Reply from the authors

Reply from the authors

Risk assessment tools validated for patients undergoing emergency laparotomy: a systematic review.

scientific article

Risk stratification tools for predicting morbidity and mortality in adult patients undergoing major surgery: qualitative systematic review

scientific article published on October 2013

Standardisation of perioperative outcome measures

scientific article

Standardizing endpoints in perioperative research.

scientific article

Stroke at high altitude diagnosed in the field using portable ultrasound

scientific article published on 29 October 2010

Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude.

scientific article published on 26 January 2017

Surgical Prehabilitation: Nutrition and Exercise

scientific article published on 01 December 2018

Survival after postoperative morbidity: a longitudinal observational cohort study

scientific article

Sustained vasomotor control of skin microcirculation in Sherpas versus altitude-naive lowlanders: Experimental evidence from Xtreme Everest 2

scientific article published on 12 September 2018

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: patient comfort

article

Systematic review of paediatric alert criteria for identifying hospitalised children at risk of critical deterioration.

scientific article

TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans

scientific article

The Postoperative Morbidity Survey was validated and used to describe morbidity after major surgery

scientific article published on 07 May 2007

The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised children.

scientific article published on 7 March 2013

The effect of neoadjuvant chemoradiotherapy on whole-body physical fitness and skeletal muscle mitochondrial oxidative phosphorylation in vivo in locally advanced rectal cancer patients--an observational pilot study

scientific article

The effect of neoadjuvant chemotherapy and chemoradiotherapy on exercise capacity and outcome following upper gastrointestinal cancer surgery: an observational cohort study

scientific article

The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery.

scientific article

The effects of exercise on pain, fatigue, insomnia, and health perceptions in patients with operable advanced stage rectal cancer prior to surgery: a pilot trial ⬇️

scientific article

The effects of neoadjuvant chemoradiotherapy and an in-hospital exercise training programme on physical fitness and quality of life in locally advanced rectal cancer patients (The EMPOWER Trial): study protocol for a randomised controlled trial. ⬇️

scientific article

The effects of neoadjuvant chemoradiotherapy on physical fitness and morbidity in rectal cancer surgery patients

scientific article

The future of UK healthcare: problems and potential solutions to a system in crisis.

scientific article

The physiological effects of hypobaric hypoxia versus normobaric hypoxia: a systematic review of crossover trials

scientific article

The problem with emergency laparotomies.

scientific article published in September 2015

The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review

scientific article published on 26 August 2017

The use of skeletal muscle near infrared spectroscopy and a vascular occlusion test at high altitude

scientific article published on September 2013

Three years of Extreme Physiology & Medicine

scientific article

Timing of surgery following neoadjuvant chemoradiotherapy in locally advanced rectal cancer - A comparison of magnetic resonance imaging at two time points and histopathological responses.

scientific article published on 26 April 2016

Tissue factor pathway inhibitor antigen and activity in 96 patients receiving heparin for cardiopulmonary bypass.

scientific article published in February 2002

Total haemoglobin mass, but not haemoglobin concentration, is associated with preoperative cardiopulmonary exercise testing-derived oxygen-consumption variables

scientific article

Transfusion in critical care - a UK regional audit of current practice

scientific article

Tricks of the trade: delivering reliable healthcare

scientific article published on 26 March 2018

Validation of preoperative cardiopulmonary exercise testing-derived variables to predict in-hospital morbidity after major colorectal surgery.

scientific article

What are the optimum components in a care bundle aimed at reducing post-operative pulmonary complications in high-risk patients?

scientific article

Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?

scientific article

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