List of works - Satoru Nagatoishi

A Peptoid with Extended Shape in Water

scientific article published on 23 August 2019

A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase.

scientific article published on 22 February 2018

A pyrene-labeled G-quadruplex oligonucleotide as a fluorescent probe for potassium ion detection in biological applications.

scientific article published in August 2005

A secondary RET mutation in the activation loop conferring resistance to vandetanib.

scientific article published on 12 February 2018

Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface

scientific article published on 27 December 2018

Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex

scientific article published on 27 January 2014

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

scientific article published on 2 March 2018

Assessment of the Protein-Protein Interactions in a Highly Concentrated Antibody Solution by Using Raman Spectroscopy.

scientific article published on 16 December 2015

Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction

scientific article published on 14 August 2019

Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes.

scientific article

Characterization of Glycoengineered Anti-HER2 Monoclonal Antibodies Produced by Using a Silkworm-Baculovirus Expression System.

scientific article published on 5 February 2018

Circular dichroism spectra demonstrate formation of the thrombin-binding DNA aptamer G-quadruplex under stabilizing-cation-deficient conditions.

scientific article

Complexation of thrombin-binding aptamer oligonucleotide carrying fluorescence resonance energy transfer (FRET) dyes at both termini with potassium ion.

scientific article published on January 2005

Conformational flexibility influences degree of hydration of nucleic acid hybrids

scientific article published on 09 November 2011

Control of Protein Adsorption to Cyclo Olefin Polymer by the Hofmeister Effect

scientific article published on 08 January 2019

DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles

scientific article published on 29 March 2012

Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction

scientific article published on 20 February 2019

Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry.

scientific article published on 14 February 2018

Differential binding of prohibitin-2 to estrogen receptor α and to drug-resistant ERα mutants.

scientific article published on 4 June 2015

Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1

scientific article published on 15 August 2018

Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus

scientific article

Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin.

scientific article published on 03 January 2017

Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer

scientific article

Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES.

scientific article published on December 2015

Fluorescence energy transfer probes based on the guanine quadruplex formation for the fluorometric detection of potassium ion.

scientific article published on 15 August 2006

G quadruplex-based FRET probes with the thrombin-binding aptamer (TBA) sequence designed for the efficient fluorometric detection of the potassium ion.

scientific article

Highly sensitive HPLC analysis and biophysical characterization of N-glycans of IgG-Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand

scientific article published on 11 May 2020

Hydration is Required in DNA G‐Quadruplex–Protein Binding ⬇️

scientific article published on June 10, 2011

Hyperthin nanochains composed of self-polymerizing protein shackles.

scientific article published in January 2013

Identification and characterization of the X-dimer of human P-cadherin: implications for homophilic cell adhesion

scientific article published on 10 March 2014

Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

scientific article published on 01 May 2018

Interaction of water with the G-quadruplex loop contributes to the binding energy of G-quadruplex to protein

scientific article

Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding ⬇️

scientific article published on April 13, 2011

Mechanism of dimerization and structural features of human LI-cadherin

scientific article published on 06 August 2021

Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage

scientific article published on 25 November 2015

Modulation of a conformational ensemble by a small molecule that inhibits key protein-protein interactions involved in cell adhesion

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin

scientific article published on 19 April 2018

On-rate modulation of cadherin interactions by chemical fragments

Osteomodulin regulates diameter and alters shape of collagen fibrils.

scientific article published on 20 May 2015

PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.

scientific article published on 24 November 2017

Per-Residue Program of Multiple Backbone Dihedral Angles of β-Peptoids via Backbone Substitutions

scientific article published on 21 January 2020

Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Coupled Receptor by Shifting the Conformational Equilibrium

scientific article published on 14 January 2019

Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery.

scientific article published on 9 January 2018

Protein stabilization by an amphiphilic short monodisperse oligo(ethylene glycol)

scientific article published on 01 May 2015

Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion

Reversible ion transportation switch by a ligand-gated synthetic supramolecular ion channel

scientific article published on 27 October 2014

Structural Basis for the Binding Mechanism of Human Serum Albumin Complexed with Cyclic Peptide Dalbavancin

scientific article published on 13 November 2020

Structural and Functional Characterization of RecG Helicase under Dilute and Molecular Crowding Conditions.

scientific article published on 8 August 2012

Structural basis for binding and transfer of heme in bacterial heme-acquisition systems

scientific article

Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach

scientific article published on 30 October 2015

Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.

scientific article published on 13 January 2015

Structural features of methionine aminopeptidase2-active core peptide essential for binding with S100A4

scientific article published on 05 July 2019

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity.

scientific article

Temperature and salt concentration alter base-sequence selectivity of a duplex DNA-binding protein

scientific article published on 01 January 2010

The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation.

scientific article published on 7 January 2017

The interaction of hyperthermophilic TATA-box binding protein with single-stranded DNA is entropically favorable and exhibits a large negative heat capacity change at high salt concentration

scientific article published on 13 May 2009

The yields of transcripts for a RNA polymerase regulated by hairpin structures in nascent RNAs.

scientific article

Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1.

scientific article

Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition

scientific article published in PLoS ONE

Thermodynamic characterization of the interaction between the human Y-box binding protein YB-1 and nucleic acids

scientific article published on 01 September 2015

Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.

scientific article

Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen.

scientific article published on 16 June 2017

[Biophysical Analysis of the Protein-Small Molecule Interactions to Develop Small Molecule Drug Discovery]

scientific article published on 01 January 2018

List of works by Satoru Nagatoishi

A Peptoid with Extended Shape in Water

A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase.

A pyrene-labeled G-quadruplex oligonucleotide as a fluorescent probe for potassium ion detection in biological applications.

A secondary RET mutation in the activation loop conferring resistance to vandetanib.

Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface

Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

Assessment of the Protein-Protein Interactions in a Highly Concentrated Antibody Solution by Using Raman Spectroscopy.

Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction

Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes.

Characterization of Glycoengineered Anti-HER2 Monoclonal Antibodies Produced by Using a Silkworm-Baculovirus Expression System.

Circular dichroism spectra demonstrate formation of the thrombin-binding DNA aptamer G-quadruplex under stabilizing-cation-deficient conditions.

Complexation of thrombin-binding aptamer oligonucleotide carrying fluorescence resonance energy transfer (FRET) dyes at both termini with potassium ion.

Conformational flexibility influences degree of hydration of nucleic acid hybrids

Control of Protein Adsorption to Cyclo Olefin Polymer by the Hofmeister Effect

DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles

Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction

Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry.

Differential binding of prohibitin-2 to estrogen receptor α and to drug-resistant ERα mutants.

Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1

Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus

Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin.

Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer

Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES.

Fluorescence energy transfer probes based on the guanine quadruplex formation for the fluorometric detection of potassium ion.

G quadruplex-based FRET probes with the thrombin-binding aptamer (TBA) sequence designed for the efficient fluorometric detection of the potassium ion.

Highly sensitive HPLC analysis and biophysical characterization of N-glycans of IgG-Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand

Hydration is Required in DNA G‐Quadruplex–Protein Binding ⬇️

Hyperthin nanochains composed of self-polymerizing protein shackles.

Identification and characterization of the X-dimer of human P-cadherin: implications for homophilic cell adhesion

Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

Interaction of water with the G-quadruplex loop contributes to the binding energy of G-quadruplex to protein

Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding ⬇️

Mechanism of dimerization and structural features of human LI-cadherin

Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage

Modulation of a conformational ensemble by a small molecule that inhibits key protein-protein interactions involved in cell adhesion

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin

On-rate modulation of cadherin interactions by chemical fragments

Osteomodulin regulates diameter and alters shape of collagen fibrils.

PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.

Per-Residue Program of Multiple Backbone Dihedral Angles of β-Peptoids via Backbone Substitutions

Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Coupled Receptor by Shifting the Conformational Equilibrium

Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery.

Protein stabilization by an amphiphilic short monodisperse oligo(ethylene glycol)

Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion

Reversible ion transportation switch by a ligand-gated synthetic supramolecular ion channel

Structural Basis for the Binding Mechanism of Human Serum Albumin Complexed with Cyclic Peptide Dalbavancin

Structural and Functional Characterization of RecG Helicase under Dilute and Molecular Crowding Conditions.

Structural basis for binding and transfer of heme in bacterial heme-acquisition systems

Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach

Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.

Structural features of methionine aminopeptidase2-active core peptide essential for binding with S100A4

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity.

Temperature and salt concentration alter base-sequence selectivity of a duplex DNA-binding protein

The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation.

The interaction of hyperthermophilic TATA-box binding protein with single-stranded DNA is entropically favorable and exhibits a large negative heat capacity change at high salt concentration

The yields of transcripts for a RNA polymerase regulated by hairpin structures in nascent RNAs.

Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1.

Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition

Thermodynamic characterization of the interaction between the human Y-box binding protein YB-1 and nucleic acids

Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.

Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen.

[Biophysical Analysis of the Protein-Small Molecule Interactions to Develop Small Molecule Drug Discovery]