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List of works by Kelvin H. Lee

8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease

scientific article

A Site-Specific Integration Reporter System that Enables Rapid Evaluation of CRISPR/Cas9-mediated Genome Editing Strategies in CHO Cells

scientific article published on 04 June 2020

A comparison of the consistency of proteome quantitation using two-dimensional electrophoresis and shotgun isobaric tagging in Escherichia coli cells

scientific article published in June 2005

A comparison of three commercially available isoelectric focusing units for proteome analysis: the multiphor, the IPGphor and the protean IEF cell

scientific article published on 01 March 2000

A differentiating neural stem cell-derived astrocytic population mitigates the inflammatory effects of TNF-α and IL-6 in an iPSC-based blood-brain barrier model

scientific article published on 31 July 2018

A framework to quantify karyotype variation associated with CHO cell line instability at a single-cell level

scientific article published on 06 December 2016

A reference genome of the Chinese hamster based on a hybrid assembly strategy

article

A single nucleotide polymorphism in ycdC alters tRNA synthetase expression and results in hypersecretion in Escherichia coli ⬇️

scientific article published on May 21, 2012

A two-dimensional electrophoresis map of Chinese hamster ovary cell proteins based on fluorescence staining

scientific article published in August 2004

Alzheimer's disease cerebrospinal fluid biomarker discovery: a proteomics approach.

scientific article

An introduction to mass spectrometry applications in biological research ⬇️

scientific article published on March 1, 2004

Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn

scientific article published on 28 February 2020

Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease

scientific article published in July 2002

Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing

scientific article published on 2 February 2018

Biochemical engineering

article published in 2002

Bioinformatic analysis of Chinese hamster ovary host cell protein lipases

scientific article published on 09 August 2018

CHOgenome.org 2.0: Genome resources and website updates.

scientific article published on 28 April 2015

Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease

scientific article published in February 2007

Chinese hamster genome database: an online resource for the CHO community at www.CHOgenome.org

scientific article

Chlorobaculum tepidum Modulates Amino Acid Composition in Response to Energy Availability, as Revealed by a Systematic Exploration of the Energy Landscape of Phototrophic Sulfur Oxidation.

scientific article

Chromosome-scale Scaffolds for the Chinese Hamster Reference Genome Assembly to Facilitate the Study of the CHO Epigenome

scientific article published on 15 May 2020

Comparison of automated in-gel digest methods for femtomole level samples

scientific article

Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease

scientific article published on January 2005

Complex and extensive post-transcriptional regulation revealed by integrative proteomic and transcriptomic analysis of metabolite stress response in Clostridium acetobutylicum

scientific article

Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells

scientific article published in May 2005

Efflux Pump Substrates Shuttled to Cytosolic or Vesicular Compartments Exhibit Different Permeability in a Quantitative Human Blood-Brain Barrier Model

scientific article published on 01 October 2018

Engineering HlyA hypersecretion in Escherichia coli based on proteomic and microarray analyses

scientific article published in January 2005

Escherichia coli--a model system that benefits from and contributes to the evolution of proteomics

scientific article published in December 2003

EvalDNA: a machine learning-based tool for the comprehensive evaluation of mammalian genome assembly quality

scientific article published on 27 November 2021

Evaluation of the design, development, and performance of a mass-flow based, open-source buffer manufacturing system

scientific article published in 2022

Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing

scientific article published on 16 January 2015

Functional genomics and proteomics as a foundation for systems biology

scientific article published in October 2003

Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology

scientific article

Genomics in mammalian cell culture bioprocessing ⬇️

scientific article published on November 4, 2011

Growth rate changes in CHO host cells are associated with karyotypic heterogeneity

scientific article

Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification

scientific article published on 9 November 2015

Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing

scientific article published on 11 December 2013

Identification of Fibulin-1 as a Human Bone Marrow Stromal (HS-5) Cell-Derived Factor That Induces Human Prostate Cancer Cell Death

scientific article published on 7 February 2017

Identification of the phosphorylation sites in the survival motor neuron protein by protein kinase A.

scientific article

Immunoglobulin G transport increases in an in vitro blood-brain barrier model with amyloid-β and with neuroinflammatory cytokines

scientific article published on 04 April 2019

Improved protease digestion conditions for membrane protein detection

scientific article published on 10 June 2015

Improved understanding of gene expression regulation using systems biology

scientific article

Insights into the relation between mRNA and protein expression patterns: I. Theoretical considerations

scientific article published in December 2003

Insights into the relation between mrna and protein expression patterns: II. Experimental observations in Escherichia coli

scientific article

Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes

scientific article published in September 2002

Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices.

scientific article published on 3 February 2018

Jay Bailey as mentor--the students' perspective.

scientific article

Kinetic characterization of sequencing grade modified trypsin

scientific article published in June 2005

Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations

scientific article published on 12 December 2016

Longitudinal analysis of novel Alzheimer's disease proteomic cerebrospinal fluid biomarkers during intravenous immunoglobulin therapy.

scientific article

Longitudinal effects of intravenous immunoglobulin on Alzheimer's cerebrospinal fluid proteome

scientific article published on July 2014

Mechanisms of precipitate formation during the purification of an Fc-fusion protein

Minimum Transendothelial Electrical Resistance Thresholds for the Study of Small and Large Molecule Drug Transport in a Human in Vitro Blood-Brain Barrier Model

scientific article published on 15 November 2016

Modeling the Effect of Amino Acids and Copper on Monoclonal Antibody Productivity and Glycosylation: A Modular Approach

scientific article published on 01 September 2020

Multiple reaction monitoring assay based on conventional liquid chromatography and electrospray ionization for simultaneous monitoring of multiple cerebrospinal fluid biomarker candidates for Alzheimer's disease

scientific article published on 24 September 2015

Murine in vitro model of the blood-brain barrier for evaluating drug transport

scientific article

NIIMBL-facilitated Active Listening Meeting between industry and FDA identifies common challenges for adoption of new biopharmaceutical manufacturing technologies

scientific article published on 28 May 2020

Optimization of endothelial cell growth in a murine in vitro blood–brain barrier model ⬇️

scientific article published on December 28, 2011

Optimization of protein sample preparation for two-dimensional electrophoresis

scientific article published in July 2012

Overexpression of cloned RhsA sequences perturbs the cellular translational machinery in Escherichia coli

scientific article

Profiling conserved microRNA expression in recombinant CHO cell lines using Illumina sequencing.

scientific article published on 23 January 2012

Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue

scientific article

Proteome analysis of factor for inversion stimulation (Fis) overproduction in Escherichia coli

scientific article published on 01 April 1999

Proteomic analysis of cerebrospinal fluid changes related to postmortem interval

scientific article published on 3 August 2006

Proteomic and physiological experiments to test Thermotoga neapolitana constraint-based model hypotheses of carbon source utilization

scientific article

Proteomic assessment of a cell model of spinal muscular atrophy

scientific article

Quantitative analysis of protein expression using amine-specific isobaric tags in Escherichia coli cells expressing rhsA elements

scientific article

Quantitative and qualitative measure of intralaboratory two-dimensional protein gel reproducibility and the effects of sample preparation, sample load, and image analysis

scientific article published in October 2003

RNA interference of cofilin in Chinese hamster ovary cells improves recombinant protein productivity

scientific article published on 21 September 2011

Recent cerebrospinal fluid biomarker studies of Alzheimer's disease

scientific article

Recovery of Chinese hamster ovary host cell proteins for proteomic analysis

scientific article published on 10 December 2013

Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.

scientific article published on November 2012

Shotgun proteomics using the iTRAQ isobaric tags

scientific article published on 10 May 2006

Site-specific Integration Ushers in a New Era of Precise CHO Cell Line Engineering

scientific article published on 23 October 2018

Studies of potential cerebrospinal fluid molecular markers for Alzheimer's disease

scientific article (publication date: July 2002)

Summary from Advanced Manufacturing Technology Workshop held at 6th Accelerating Biopharmaceutical Development Meeting

scientific article published on 15 June 2020

Synthesis and characterization of high-throughput nanofabricated poly(4-hydroxy styrene) membranes for in vitro models of barrier tissue

scientific article published on 21 May 2012

Systematic Identification of Safe Harbor Regions in the CHO genome through a Comprehensive Epigenome Analysis

scientific article published on 13 October 2020

Targeted human cerebrospinal fluid proteomics for the validation of multiple Alzheimer's disease biomarker candidates

scientific article published on 10 May 2013

The effect of astrocytes on the induction of barrier properties in aortic endothelial cells

scientific article published on 27 May 2011

The fickle CHO: a review of the causes, implications, and potential alleviation of the CHO cell line instability problem

scientific article published on 28 February 2019

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

scientific article

The scaled volume as an image analysis variable for detecting changes in protein expression levels by silver stain

scientific article published on 01 May 2001

Totally asymmetric exclusion process with extended objects: A model for protein synthesis ⬇️

scientific article published on August 18, 2003

Toward improved host cell protein impurity assessment

scientific article published on 22 June 2016

Towards two-dimensional electrophoresis mapping of the cerebrospinal fluid proteome from a single individual

scientific article published in August 2004

Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels.

scientific article published on 29 August 2017

Two-dimensional protein electrophoresis: from molecular pathway discovery to biomarker discovery in neurological disorders

scientific article published on July 2006

Workflow for quantitative proteomic analysis of Clostridium acetobutylicum ATCC 824 using iTRAQ tags

scientific article published on 22 March 2013

iTRAQPak: an R based analysis and visualization package for 8-plex isobaric protein expression data

scientific article

miRNA expression in CHO: nature knows best

scientific article published on 12 February 2014

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