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Authors whose works are in public domain in at least one jurisdiction

List of works by Joseph W Polli

Assessment of the drug interaction risk for remogliflozin etabonate, a sodium-dependent glucose cotransporter-2 inhibitor: evidence from in vitro, human mass balance, and ketoconazole interaction studies

scientific article published on 30 July 2012

Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.

scientific article

Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and Matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity.

scientific article

Conference Report: A Hitchhiker’s Guide to Outsourcing ADME Studies: The Inside of Outsourcing ⬇️

scientific article published on February 1, 2013

Developmental expression of calmodulin-dependent cyclic nucleotide phosphodiesterase in rat brain.

scientific article

Developmental expression of neuronal calmodulin-binding proteins in rat brain.

scientific article published in April 1990

Developmental expression of the 25-kDa synaptosomal-associated protein (SNAP-25) in rat brain ⬇️

scientific article published on June 15, 1991

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

scientific article published on 12 July 2018

Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam

scientific article published on 4 September 2015

Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: fromin vitrodata to clinical study design ⬇️

scientific article published on December 21, 2012

Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier.

scientific article published on August 2004

Expression of calmodulin-dependent enzymes in developing rat striatum is not affected by perturbation of dopaminergic systems ⬇️

scientific article published on October 1, 1991

Expression of the calmodulin-dependent protein phosphatase, calcineurin, in rat brain: developmental patterns and the role of nigrostriatal innervation ⬇️

scientific article published on November 19, 1991

First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus

scientific article

If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

scientific article

In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates.

scientific article published on October 2004

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

scientific article

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

scientific article published on 2 February 2006

Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

scientific article published on 29 October 2007

Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.

scientific article

Membrane transporters in drug development

scientific article (publication date: March 2010)

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.

scientific article published on 28 April 2005

P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.

scientific article published on 30 November 2006

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

scientific article published on October 2003

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

scientific article published on December 2002

PhRMA white paper on ADME pharmacogenomics.

scientific article published on 04 June 2008

Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.

scientific article published on April 2004

Preparation, characterization and biological properties of biotinylated derivatives of calmodulin

scientific article published on May 1991

Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial

scientific article published on 01 October 2000

Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus.

scientific article published on 30 April 2013

The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects.

scientific article published on 22 April 2008

The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.

scientific article published on 22 October 2004

The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.

scientific article published on 23 January 2008

The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.

scientific article published on July 2004

Toxicokinetics and toxicity of atorvastatin in dogs

scientific article published on 16 September 2015

Transporter Studies in Drug Development: Experience to Date and Follow-Up on Decision Trees From the International Transporter Consortium

scientific article published on April 10, 2013

Understanding the transport properties of metabolites: case studies and considerations for drug development.

scientific article published on 17 December 2013

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.

scientific article

Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.

scientific article published on 14 February 2013

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