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List of works by Kevin Pfleger

Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.

scientific article published on 29 January 2009

Analysis of protein-protein interactions using bioluminescence resonance energy transfer

scientific article

Application of BRET to monitor ligand binding to GPCRs

scientific article

Application of G protein-coupled receptor-heteromer identification technology to monitor β-arrestin recruitment to G protein-coupled receptor heteromers

scientific article

BRET-based assay to monitor EGFR transactivation by the ATR reveals G protein-independent activation and ATR-EGFR complexes

scientific article published on 19 October 2018

Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions

scientific article published on 01 January 2006

Biophysical Detection of Diversity and Bias in GPCR Function

scientific article published on 05 March 2014

Building a new conceptual framework for receptor heteromers

scientific article

CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans

scientific article published in 2024

Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations

scientific article

Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V)

scientific article published on 6 June 2013

Conformational Constraint of Mammalian, Chicken, and Salmon GnRHs, But Not GnRH II, Enhances Binding at Mammalian and Nonmammalian Receptors: Evidence for Preconfiguration of GnRH II

article

Deleterious GRM1 mutations in schizophrenia

scientific article

Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells

scientific article published on 23 September 2008

Effect of enhanced Renilla luciferase and fluorescent protein variants on the Förster distance of Bioluminescence resonance energy transfer (BRET).

scientific article published in August 2012

Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins

scientific article

Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells

scientific article published on 21 February 2006

Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding.

scientific article published on 28 August 2015

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease

scientific article

G Protein-Coupled Receptor Heteromer Identification Technology: Identification and Profiling of GPCR Heteromers ⬇️

scientific article published on May 31, 2011

G Protein-Coupled Receptor Heteromers.

scientific article published on 22 October 2015

G protein coupled receptors as drug targets: the role of beta-arrestins

scientific article published on March 2008

G protein-coupled receptor dimers: functional consequences, disease states and drug targets

scientific article published on 08 April 2008

G-protein coupled receptor oligomerization in neuroendocrine pathways

scientific article published on December 2003

G-protein-coupled receptors in drug discovery--seventh annual Informa conference. Part 2--GPCR activity and ligand binding.

scientific article published in May 2009

Gonadotropin-releasing hormone receptor-mediated growth suppression of immortalized LbetaT2 gonadotrope and stable HEK293 cell lines

scientific journal article

Helix I of beta-arrestin is involved in postendocytic trafficking but is not required for membrane translocation, receptor binding, and internalization

scientific article

Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format

scientific article published on 23 June 2014

Identification and profiling of CXCR3–CXCR4 chemokine receptor heteromer complexes ⬇️

scientific article published on April 1, 2013

Identification and profiling of novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer.

scientific article published on 27 February 2012

Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET).

scientific article

Insights into the Interaction of LVV-Hemorphin-7 with Angiotensin II Type 1 Receptor

scientific article published on 28 December 2020

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression

scientific article published in PLoS ONE

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

scientific article published on 23 May 2017

Molecular determinants of orexin receptor-arrestin-ubiquitin complex formation

scientific article published on January 2014

Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells

scientific article

Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking.

scientific article published on 29 June 2016

NanoBRET: The Bright Future of Proximity-Based Assays

scientific article published on 26 March 2019

Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology

scientific article

Quantitative Förster resonance energy transfer efficiency measurements using simultaneous spectral unmixing of excitation and emission spectra

scientific article

Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization

scientific article

Receptor-Heteromer Investigation Technology and its application using BRET

scientific article

Study of GPCR–Protein Interactions by BRET ⬇️

scientific article published on January 1, 2011

Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes

scientific article

Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time

scientific article

i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.

scientific article

mGlu5 Receptor Functional Interactions and Addiction

scientific article published on 7 May 2012

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