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List of works by Denise L Doolan

2018 ISV Congress: advances in the 100 years since the world's deadliest pandemic

scientific article published on 01 January 2019

A Plasmodium vivax Plasmid DNA- and Adenovirus-Vectored Malaria Vaccine Encoding Blood-Stage Antigens AMA1 and MSP142 in a Prime/Boost Heterologous Immunization Regimen Partially Protects Aotus Monkeys against Blood-Stage Challenge

scientific article

A balanced pro-inflammatory and regulatory cytokine signature in young African children is associated with lower risk of clinical malaria

scientific article published on 01 August 2019

A novel candidate vaccine for cytauxzoonosis inferred from comparative apicomplexan genomics

scientific article

A novel population of memory-activated natural killer cells associated with low parasitaemia in Plasmodium falciparum-exposed sickle-cell trait children

scientific article published on 02 April 2020

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

scientific article

Acquired immunity to malaria

scientific article

Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

scientific article

Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults

scientific article (publication date: 2011)

Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component

scientific article (publication date: 2011)

Amino acid supply and protein metabolism in Ehrlich ascites tumour cells. 1. Identification of limiting amino acids

scientific article published on 01 January 1987

Amino acid supply and protein metabolism in Ehrlich ascites tumour cells. 2. Incorporation of 14C-tyrosine.

scientific article published in January 1987

An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas

scientific article (publication date: March 2014)

Anomalies in T Cell Function Are Associated With Individuals at Risk of Mycobacterium abscessus Complex Infection.

scientific article

Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum

scientific article

CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein.

scientific article

CD8<sup>+</sup> T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

scientific article published on 15 April 2021

Can malaria DNA vaccines on their own be as immunogenic and protective as prime-boost approaches to immunization?

scientific article published on January 1, 2000

Case study: the Interact Home Telehealth Project.

scientific article

Casting a Wide Net around Immunity to Malaria Catches p53

scientific article published on 01 October 2019

Chemically Attenuated Blood-Stage Plasmodium yoelii Parasites Induce Long-Lived and Strain-Transcending Protection

scientific article published on 31 May 2016

Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses

scientific article published on 19 June 2019

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA

scientific article published on November 2012

Combining community participatory research with a randomized clinical trial: the Protecting the Hood Against Tobacco (PHAT) smoking cessation study.

scientific article

Computerized physician order entry systems in hospitals: mandates and incentives.

scientific article published in July 2002

Correction: A Novel Candidate Vaccine for Cytauxzoonosis Inferred from Comparative Apicomplexan Genomics.

scientific article published on 23 October 2013

Correction: Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses

scientific article (publication date: 4 May 2012)

DNA Vaccination as an Approach to Malaria Control: Current Status and Strategies ⬇️

scientific article published on January 1, 1998

DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity

scientific article

DNA vaccination.

scientific article published in January 2002

DNA vaccines for malaria: the past, the present, & the future

scientific article published on August 1, 1997

Deciphering host immunity to malaria using systems immunology

scientific article published on 14 October 2019

Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties ⬇️

article

Defining the targets of antiparasitic compounds.

scientific article

Degenerate Cytotoxic T Cell Epitopes from P. falciparum Restricted by Multiple HLA-A and HLA-B Supertype Alleles ⬇️

scientific article published on July 1, 1997

Development of a cytokine-secreting-based assay for the identification, sorting and transcriptomic analysis of polyfunctional human T cells

scientific article published on 01 October 2015

Dichotomous miR expression and immune responses following primary blood-stage malaria

scientific article

Dissecting T cell or antibody immunodominance in a complex host-pathogen system

Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

scientific article

Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c+ Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation

scientific article

Editorial

scientific article published on 16 August 2012

Efficacy of smoking cessation intervention among special populations: review of the literature from 2000 to 2005.

scientific article published on July 2006

Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation.

scientific article

Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale.

scientific article

Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma

scientific article published on 16 October 2019

Evidence for limited activation of distinct CD4+ T cell subsets in response to the Plasmodium falciparum circumsporozoite protein in Papua New Guinea.

scientific article published in March 1994

Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-γ production and IFN-γ-secreting cells ⬇️

scientific article published on November 1, 2001

Foreword--MBP thematic issue on genomics.

scientific article published in December 2001

Genome- and proteome-wide screening strategies for antigen discovery and immunogen design

scientific article published on 02 January 2014

Genome-based vaccine design: the promise for malaria and other infectious diseases.

scientific article published on 06 September 2014

Harnessing immune responses against Plasmodium for rational vaccine design.

scientific article published on 30 April 2011

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection.

scientific article

Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge

scientific article (publication date: 2013)

Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria

scientific article published on 07 June 2009

Human challenge models: tools to accelerate the development of malaria vaccines

scientific article published on 27 February 2019

IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response.

scientific article published on 18 June 2010

ISV Congress back to Europe

article

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

scientific article

Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data

scientific article

Identification of a novel, EBV-based antibody risk stratification signature for early detection of nasopharyngeal carcinoma in Taiwan.

scientific article published on 4 January 2018

Identification of antigens via protein microarray and assessment of expression library immunization against cytauxzoonosis

scientific article published on 29 December 2018

Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques

scientific article

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

scientific article published in 2013

IgM in human immunity to Plasmodium falciparum malaria

scientific article published on 25 September 2019

Immune Signature Against Plasmodium falciparum Antigens Predicts Clinical Immunity in Distinct Malaria Endemic Communities

scientific article published on 28 October 2019

Immune response to pre-erythrocytic stages of malaria parasites.

scientific article

Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model.

scientific article published on 08 July 2013

Immunomics: a 21st century approach to vaccine development for complex pathogens

scientific article published on February 2016

Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine ⬇️

scientific article published on October 16, 1998

Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine.

scientific article

Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization.

scientific article

Influence of Physicochemical Properties of Lipopeptide Adjuvants on the Immune Response: A Rationale for Engineering a Potent Vaccine

scientific article published on 19 June 2018

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

scientific article published on 05 February 2021

Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice

scientific article published in September 2002

Keeping watch: California's staffing ratios.

scientific article

Large screen approaches to identify novel malaria vaccine candidates

scientific article published on 28 September 2015

Malaria DNA vaccines in Aotus monkeys ⬇️

scientific article published on June 1, 1997

Massive transfusion--evaluation of current clinical practice and outcome in two large teaching hospital trusts in Northern England.

scientific article published on 3 June 2009

Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

scientific article

Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues.

scientific article

Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.

scientific article

Multilaboratory Assessment of Epstein-Barr Virus Serologic Assays: the Case for Standardization

scientific article published on 23 October 2019

Non-toxic derivatives of LT as potent adjuvants.

scientific article published on 14 December 2010

Novel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses.

scientific article published on 8 November 2017

Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates

scientific article published on 5 May 2015

Patterns of inter-individual variability in the antibody repertoire targeting proteins across the Epstein-Barr virus proteome.

scientific article

Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation

scientific article

Plasmodium falciparum CS protein--prime malaria vaccine candidate: definition of the human CTL domain and analysis of its variation.

scientific article

Plasmodium immunomics.

scientific article

Plasmodium vivax but Not Plasmodium falciparum Blood-Stage Infection in Humans Is Associated with the Expansion of a CD8+ T Cell Population with Cytotoxic Potential.

scientific article

Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct.

scientific article published on 09 February 2017

Pre–erythrocytic–stage immune effector mechanisms inPlasmodiumspp. infections ⬇️

scientific article published on September 29, 1997

Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling

scientific article published on 19 August 2014

Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015: Yogyakarta, Indonesia. 4-6 June 2015.

scientific article published on 13 April 2016

Profiling humoral immune responses to P. falciparum infection with protein microarrays

scientific article

Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection

scientific article published on 22 February 2016

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

scientific article (publication date: 15 April 2002)

Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants

scientific article published on 01 November 2019

Protein microarrays for parasite antigen discovery.

scientific article

Recent advances in proteomic applications for schistosomiasis research: potential clinical impact

scientific article published on 11 December 2016

Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production

scientific article

Schistosomiasis vaccine discovery using immunomics

scientific article published on 28 January 2010

Simultaneous Induction of Multiple Antigen-Specific Cytotoxic T Lymphocytes in Nonhuman Primates by Immunization with a Mixture of FourPlasmodium falciparumDNA Plasmids ⬇️

scientific article published on September 1, 1998

Smoking cessation interventions and older adults.

scientific article published on January 2008

Specific humoral response of hosts with variable schistosomiasis susceptibility.

scientific article

Status of malaria vaccine R&D in 2007. Malaria Vaccines for the World 2007, September 17-19th, 2007, London, UK.

scientific article published in December 2007

Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies

scientific article published on 10 August 2009

Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use ⬇️

scientific article published on June 1, 1997

Subcutaneous cholera toxin exposure induces potent CD103⁺ dermal dendritic cell activation and migration.

scientific article published on September 2013

Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype

scientific article published on 10 September 2020

Synthesis and characterisation of self-assembled and self-adjuvanting asymmetric multi-epitope lipopeptides of ovalbumin

scientific article

Synthesis of Mannosylated Lipopeptides with Receptor Targeting Properties.

scientific article published on 6 January 2016

Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8(+) T-cell responses.

scientific article

Systems Approaches towards Molecular Profiling of Human Immunity.

scientific article published on 05 December 2015

The Association between the Comprehensive Epstein–Barr Virus Serologic Profile and Endemic Burkitt Lymphoma

scientific article published on 16 October 2019

The Australasian contribution to malaria vaccine development.

scientific article published on August 2010

The US capitol bioterrorism anthrax exposures: clinical epidemiological and immunological characteristics

scientific article published on 06 December 2006

The Women's Initiative for Nonsmoking (WINS) XI: age-related differences in smoking cessation responses among women with cardiovascular disease.

scientific article

The case for a rational genome-based vaccine against malaria.

scientific article

The development of a multivalent DNA vaccine for malaria ⬇️

scientific article published on January 1, 1997

The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial

scientific article (publication date: 2012)

The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area

scientific article published on 8 August 2011

The use of computers for clinical care: a case series of advanced U.S. sites.

scientific article

The use of health information technology in seven nations.

scientific article published on 25 July 2008

Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions

scientific article

Toward clinical trials of DNA vaccines against malaria ⬇️

scientific article published on August 1, 1997

Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection

scientific article published on October 2016

Using an existing data set to answer new research questions: a methodological review.

scientific article

Utilization of genomic sequence information to develop malaria vaccines ⬇️

scientific article published on November 1, 2003

Vaccinomics for the major blood feeding helminths of humans

scientific article published on 16 June 2011

Vaxfectin enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses

scientific article published on 30 October 2009

Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines

scientific article published on 2 November 2005

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