List of works - François Radvanyi

A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis

scientific article published on 3 August 2015

A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1

scientific article

A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

scientific article published on 22 September 2021

A meta-analysis of the relationship between FGFR3 and TP53 mutations in bladder cancer.

scientific article

A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

scientific article

A prognostic DNA signature for T1T2 node-negative breast cancer patients

scientific article published on 01 December 2010

A prospective multicenter study on bladder cancer: the COBLAnCE cohort.

scientific article

A sensitive and continuous fluorometric assay for phospholipase A2 using pyrene-labeled phospholipids in the presence of serum albumin

scientific article published on 01 February 1989

Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans

scientific article published on 16 March 2005

An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

scientific article published on 20 February 2018

An essential role for decorin in bladder cancer invasiveness

scientific article published on 20 October 2013

Analysis of array CGH data: from signal ratio to gain and loss of DNA regions

scientific article

Analysis of fibroblast growth factor receptor 3 G697C mutation in oral squamous cell carcinomas

scientific article published on 01 May 2007

Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients.

scientific article

Bayesian hierarchical model for identifying changes in gene expression from microarray experiments.

scientific article published on January 2002

Binding of crotoxin, a presynaptic phospholipase A2 neurotoxin, to negatively charged phospholipid vesicles

scientific article published on 01 October 1989

Binding of divalent and trivalent cations with crotoxin and with its phospholipase and its non-catalytic subunits: effects on enzymatic activity and on the interaction of phospholipase component with phospholipids

scientific article published on 01 November 1989

CDKN2A homozygous deletion is associated with muscle invasion in FGFR3-mutated urothelial bladder carcinoma

scientific article published on 8 May 2012

Characterization of a new brain-specific isoform of the EWS oncoprotein.

scientific article published in June 2001

Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation

scientific article

CoRegNet: reconstruction and integrated analysis of co-regulatory networks.

scientific article

Comparison of crotoxin isoforms reveals that stability of the complex plays a major role in its pharmacological action

scientific article published on 01 June 1993

Computation of recurrent minimal genomic alterations from array-CGH data

scientific article

Crotoxin, a phospholipase A2 neurotoxin from snake venom, interacts with epithelial mammary cells, is internalized and induces secretion

scientific article published on 01 November 1991

Deregulation of Rab and Rab effector genes in bladder cancer.

scientific article

Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors

scientific article published on 25 September 2018

Determination of phospholipase A2 activity by a colorimetric assay using a pH indicator.

scientific article

Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue

scientific article published on 01 March 1999

Differential transcription factor expression by human epithelial cells of buccal and urothelial derivation

scientific article published on 26 May 2018

EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype

scientific article

Epidermal growth factor receptor regulates normal urothelial regeneration

scientific article

Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder

scientific article published on 01 February 1995

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

scientific article published in September 1999

Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder

scientific article published on 01 June 1997

Gefitinib inhibits the growth and invasion of urothelial carcinoma cell lines in which Akt and MAPK activation is dependent on constitutive epidermal growth factor receptor activation

scientific article published on May 2006

Gene Expression Signatures Predict Outcome in Non-Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

article

Gene expression analysis by real-time reverse transcription polymerase chain reaction: influence of tissue handling.

scientific article

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

scientific article published on 26 May 2014

Growth, differentiation and senescence of normal human urothelium in an organ-like culture

scientific article published on 01 June 2004

HMCan: a method for detecting chromatin modifications in cancer samples using ChIP-seq data.

scientific article

IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer

scientific article published on 7 September 2017

Identification in Daily Practice of Patients With Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer): Revised Bethesda Guidelines-Based ApproachVersusMolecular Screening

scientific article published on 27 August 2008

Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma

scientific article

Identification of targeted therapy for an aggressive subgroup of muscle-invasive bladder cancers

scientific article published on 9 July 2015

Identifying genes from up-down properties of microarray expression series.

scientific article published in October 2005

Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes

scientific article published on 13 November 2014

Inhibition of human bladder tumour cell growth by fibroblast growth factor receptor 2b is independent of its kinase activity. Involvement of the carboxy-terminal region of the receptor.

scientific article

Inhibitors of the TAM subfamily of tyrosine kinases: Synthesis and biological evaluation ⬇️

scientific article published on June 12, 2012

Integrated genomic and transcriptomic analysis of ductal carcinoma in situ of the breast

scientific article

Integrative modelling of the influence of MAPK network on cancer cell fate decision

scientific article (publication date: October 2013)

LICORN: learning cooperative regulation networks from gene expression data

scientific article

Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine

scientific article

Le récepteur de type 3 des FGF (FGFR3) : de la chondrodysplasie… au cancer de la vessie

Loss of heterozygosity on 10q and mutational status of PTEN and BMPR1A in colorectal primary tumours and metastases

scientific article published on March 2004

MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors

scientific article (publication date: 28 September 2006)

Milk fat globule--epidermal growth factor--factor VIII (MFGE8)/lactadherin promotes bladder tumor development.

scientific article

Moderate intergenerational and somatic instability of a 55-CTG repeat in transgenic mice.

scientific article

Modulation of cytokeratin subtype, EGF receptor, and androgen receptor expression during progression of prostate cancer*1 ⬇️

scientific article published on September 1, 1998

Molecular Grade (FGFR3/MIB-1) and EORTC Risk Scores Are Predictive in Primary Non–Muscle-Invasive Bladder Cancer

scientific article published on 09 June 2010

Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome

scientific article published in May 2003

Multicentre randomised phase II trial of gemcitabine+platinum, with or without trastuzumab, in advanced or metastatic urothelial carcinoma overexpressing Her2.

scientific article published on 15 November 2014

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma ⬇️

scientific article published on September 20, 1991

Neutralization of lethal potency and inhibition of enzymatic activity of a phospholipase A2 neurotoxin, crotoxin, by non-precipitating antibodies (Fab)

scientific article published on 01 February 1989

New aminopyrimidine derivatives as inhibitors of the TAM family.

scientific article

Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma.

scientific article published in January 2010

PI3K/AKT pathway activation in bladder carcinogenesis

scientific article published on 24 October 2013

PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.

scientific article published on 17 September 2013

PRC2-independent chromatin compaction and transcriptional repression in cancer

scientific article published on 27 January 2014

Pepper: cytoscape app for protein complex expansion using protein-protein interaction networks

scientific article published on 18 August 2014

Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.

scientific article

Prediction of recurrence of non muscle-invasive bladder cancer by means of a protein signature identified by antibody microarray analyses.

scientific article published on 29 April 2014

Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein status.

scientific article

Purification of an acidic phospholipase A2 from Bothrops lanceolatus (fer de lance) venom: molecular and enzymatic properties

scientific article published on 01 September 1994

Quantitative Analysis of Protein Complex Constituents and Their Phosphorylation States on a LTQ-Orbitrap Instrument ⬇️

scientific article published on October 1, 2010

Recurrent activating mutations of PPARγ associated with luminal bladder tumors

scientific article published in Nature Communications

Regional copy number-independent deregulation of transcription in cancer

scientific article published on 12 November 2006

Relationship between E-cadherin and fibroblast growth factor receptor 2b expression in bladder carcinomas

scientific article published on 01 October 1999

SegCorr a statistical procedure for the detection of genomic regions of correlated expression.

scientific article published on 11 July 2017

Selecting biomedical data sources according to user preferences

scientific article

Sensitive allele-specific PCR assay able to detect FGFR3 mutations in tumors and urine from patients with urothelial cell carcinoma of the bladder

scientific article published on 01 August 2005

Site-specific epsilon-NH2 monoacylation of pancreatic phospholipase A2. 2. Transformation of soluble phospholipase A2 into a highly penetrating "membrane-bound" form

scientific article published on 01 March 1988

Spatial normalization of array-CGH data

scientific article

Synthesis and biological evaluation of a triazole-based library of pyrido[2,3-d]pyrimidines as FGFR3 tyrosine kinase inhibitors

scientific article

Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01

scientific article published on 01 January 2019

VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles

scientific article published on 4 July 2006

Visualizing Chromosomes as Transcriptome Correlation Maps: Evidence of Chromosomal Domains Containing Co-expressed Genes—A Study of 130 Invasive Ductal Breast Carcinomas

article

[Molecular events involved in the metastatic process]

scientific article published on 01 November 2008

p15 INK4b in bladder carcinomas: decreased expression in superficial tumours ⬇️

scientific article published on November 16, 2001

List of works by François Radvanyi

A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis

A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1

A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

A meta-analysis of the relationship between FGFR3 and TP53 mutations in bladder cancer.

A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

A prognostic DNA signature for T1T2 node-negative breast cancer patients

A prospective multicenter study on bladder cancer: the COBLAnCE cohort.

A sensitive and continuous fluorometric assay for phospholipase A2 using pyrene-labeled phospholipids in the presence of serum albumin

Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans

An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

An essential role for decorin in bladder cancer invasiveness

Analysis of array CGH data: from signal ratio to gain and loss of DNA regions

Analysis of fibroblast growth factor receptor 3 G697C mutation in oral squamous cell carcinomas

Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients.

Bayesian hierarchical model for identifying changes in gene expression from microarray experiments.

Binding of crotoxin, a presynaptic phospholipase A2 neurotoxin, to negatively charged phospholipid vesicles

Binding of divalent and trivalent cations with crotoxin and with its phospholipase and its non-catalytic subunits: effects on enzymatic activity and on the interaction of phospholipase component with phospholipids

CDKN2A homozygous deletion is associated with muscle invasion in FGFR3-mutated urothelial bladder carcinoma

Characterization of a new brain-specific isoform of the EWS oncoprotein.

Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation

CoRegNet: reconstruction and integrated analysis of co-regulatory networks.

Comparison of crotoxin isoforms reveals that stability of the complex plays a major role in its pharmacological action

Computation of recurrent minimal genomic alterations from array-CGH data

Crotoxin, a phospholipase A2 neurotoxin from snake venom, interacts with epithelial mammary cells, is internalized and induces secretion

Deregulation of Rab and Rab effector genes in bladder cancer.

Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors

Determination of phospholipase A2 activity by a colorimetric assay using a pH indicator.

Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue

Differential transcription factor expression by human epithelial cells of buccal and urothelial derivation

EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype

Epidermal growth factor receptor regulates normal urothelial regeneration

Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder

Gefitinib inhibits the growth and invasion of urothelial carcinoma cell lines in which Akt and MAPK activation is dependent on constitutive epidermal growth factor receptor activation

Gene Expression Signatures Predict Outcome in Non-Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Gene expression analysis by real-time reverse transcription polymerase chain reaction: influence of tissue handling.

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

Growth, differentiation and senescence of normal human urothelium in an organ-like culture

HMCan: a method for detecting chromatin modifications in cancer samples using ChIP-seq data.

IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer

Identification in Daily Practice of Patients With Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer): Revised Bethesda Guidelines-Based ApproachVersusMolecular Screening

Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma

Identification of targeted therapy for an aggressive subgroup of muscle-invasive bladder cancers

Identifying genes from up-down properties of microarray expression series.

Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes

Inhibition of human bladder tumour cell growth by fibroblast growth factor receptor 2b is independent of its kinase activity. Involvement of the carboxy-terminal region of the receptor.

Inhibitors of the TAM subfamily of tyrosine kinases: Synthesis and biological evaluation ⬇️

Integrated genomic and transcriptomic analysis of ductal carcinoma in situ of the breast

Integrative modelling of the influence of MAPK network on cancer cell fate decision

LICORN: learning cooperative regulation networks from gene expression data

Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine

Le récepteur de type 3 des FGF (FGFR3) : de la chondrodysplasie… au cancer de la vessie

Loss of heterozygosity on 10q and mutational status of PTEN and BMPR1A in colorectal primary tumours and metastases

MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors

Milk fat globule--epidermal growth factor--factor VIII (MFGE8)/lactadherin promotes bladder tumor development.

Moderate intergenerational and somatic instability of a 55-CTG repeat in transgenic mice.

Modulation of cytokeratin subtype, EGF receptor, and androgen receptor expression during progression of prostate cancer*1 ⬇️

Molecular Grade (FGFR3/MIB-1) and EORTC Risk Scores Are Predictive in Primary Non–Muscle-Invasive Bladder Cancer

Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome

Multicentre randomised phase II trial of gemcitabine+platinum, with or without trastuzumab, in advanced or metastatic urothelial carcinoma overexpressing Her2.

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma ⬇️

Neutralization of lethal potency and inhibition of enzymatic activity of a phospholipase A2 neurotoxin, crotoxin, by non-precipitating antibodies (Fab)

New aminopyrimidine derivatives as inhibitors of the TAM family.

Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma.

PI3K/AKT pathway activation in bladder carcinogenesis

PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.

PRC2-independent chromatin compaction and transcriptional repression in cancer

Pepper: cytoscape app for protein complex expansion using protein-protein interaction networks

Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.

Prediction of recurrence of non muscle-invasive bladder cancer by means of a protein signature identified by antibody microarray analyses.

Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein status.

Purification of an acidic phospholipase A2 from Bothrops lanceolatus (fer de lance) venom: molecular and enzymatic properties

Quantitative Analysis of Protein Complex Constituents and Their Phosphorylation States on a LTQ-Orbitrap Instrument ⬇️

Recurrent activating mutations of PPARγ associated with luminal bladder tumors

Regional copy number-independent deregulation of transcription in cancer

Relationship between E-cadherin and fibroblast growth factor receptor 2b expression in bladder carcinomas

SegCorr a statistical procedure for the detection of genomic regions of correlated expression.

Selecting biomedical data sources according to user preferences