List of works - Jeremy Nathans

A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

scientific article published on 08 January 2020

A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.

scientific article published in March 2003

A strabismus susceptibility locus on chromosome 7p

scientific article

A visual pigment from chicken that resembles rhodopsin: amino acid sequence, gene structure, and functional expression

scientific article published on April 7, 1992

Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation

scientific article published on February 15, 1992

Absorption spectra of the hybrid pigments responsible for anomalous color vision

scientific article published on October 16, 1992

Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions

scholarly article by Xi Peng et al published 22 October 2018 in eLife

An MRI-based atlas and database of the developing mouse brain

scientific article

An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus.

scientific article published in May 2008

An essential role for frizzled 5 in mammalian ocular development

scientific journal article

An evolutionary perspective on the photoreceptor damage response.

scientific article

An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase.

scientific article

Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling

scientific article (publication date: 12 December 2003)

Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling.

scientific article published in January 2006

Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

article

Bovine pancreatic trypsin inhibitor-trypsin complex as a detection system for recombinant proteins ⬇️

scientific article published on January 1, 1993

Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells ⬇️

scientific article published on October 1, 1993

Ca2+-activated Cl- current from human bestrophin-4 in excised membrane patches

scientific article published on 15 May 2006

Canonical WNT signaling components in vascular development and barrier formation

scientific article

Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease

scientific article published on January 2014

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura

scientific article published on 22 August 2017

China's Plan Flawed But Courageous ⬇️

scientific article published on December 17, 2010

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function

scientific journal article

Climate change and the integrity of science

scientific article

Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone ⬇️

scientific article published on October 1, 1979

Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis

scientific article

Complete morphologies of basal forebrain cholinergic neurons in the mouse

scientific article

Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing

scientific article published on 16 December 2019

Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis

scientific article published on 18 July 2019

Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

scientific article published on 21 October 2020

Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells

scientific article

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

Effects of L1 retrotransposon insertion on transcript processing, localization and accumulation: lessons from the retinal degeneration 7 mouse and implications for the genomic ecology of L1 elements

scientific article published on 24 May 2006

Emergence of novel color vision in mice engineered to express a human cone photopigment

scientific article

Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis

scientific article published on 16 September 2013

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain

scientific article published on June 2015

Epigenomic landscapes of retinal rods and cones

scientific article

Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development ⬇️

scientific article published on August 19, 1997

Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis

scientific article

Expression of the Norrie disease gene (Ndp) in developing and adult mouse eye, ear, and brain

scientific article

Flat mount imaging of mouse skin and its application to the analysis of hair follicle patterning and sensory axon morphology

scientific article

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

scientific journal article

Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes

scientific article

Frizzled Receptors in Development and Disease

scientific article

Frizzled-3 is required for the development of major fiber tracts in the rostral CNS.

scientific article published in October 2002

Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

scientific article published in 2013

Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system

scientific article

Frizzled6 controls hair patterning in mice

scientific journal article

Functional assembly of accessory optic system circuitry critical for compensatory eye movements

scientific article published on 7 May 2015

Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse

scientific article published on 01 June 2007

Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney

scientific article

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision

scientific article

Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology

scientific article

Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling

scientific article

Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II

scientific article published on 01 March 1992

How scientists can reduce their carbon footprint

scientific article

How to draw the line in biomedical research

scientific article published on 19 March 2013

Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression ⬇️

scientific article (publication date: August 1992)

Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution

scientific article published on 15 April 2019

Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C (rdgC) ⬇️

scientific article published on October 14, 1997

Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles

scientific journal article

Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance.

scientific article

Intramembrane Proteolysis of Astrotactins

scientific article published on 18 January 2017

Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin ⬇️

scientific article published on October 1, 1983

Macular degeneration: recent advances and therapeutic opportunities.

scientific article

Mechanisms of spectral tuning in the mouse green cone pigment ⬇️

scientific article published on August 5, 1997

Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.

scientific article published on 21 June 2019

Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound

scientific article published on November 30, 1978

Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling

scientific article

Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: Analysis of wild type and mutant cells using genetically-directed sparse labeling ⬇️

scientific article published on September 6, 2010

Mutational analysis of Norrin-Frizzled4 recognition

scientific article published on 6 December 2006

New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling

scientific article

Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization

scientific article

Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity

scientific article published on December 2012

Order from disorder: Self-organization in mammalian hair patterning

scientific journal article

Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance

scientific article published on October 2014

Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling

scientific article published on 6 September 2016

Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium

scientific article

Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium ⬇️

scientific article published on September 2, 1997

Photobleaching difference absorption spectra of human cone pigments: quantitative analysis and comparison to other methods

scientific article published on December 1, 1992

Population growth: Help to make food go further in Egypt.

scientific article

Preclinical assessment of CNS drug action using eye movements in mice

scientific article

Proteolytic shedding of the extracellular domain of photoreceptor cadherin. Implications for outer segment assembly

scientific article

Proximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish

scientific article published on 13 February 2004

Quantitative analysis of neuronal morphologies in the mouse retina visualized by using a genetically directed reporter.

scientific article published in December 2004

Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems

scientific article published on 23 September 2015

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

scientific article published on 7 August 2017

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

scientific article published in August 2017

Responses of hair follicle-associated structures to loss of planar cell polarity signaling

scientific article published on 19 February 2013

Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations

scientific article

Rhodopsin mutations in autosomal dominant retinitis pigmentosa ⬇️

scientific article published on August 1, 1991

Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes

scientific article

Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems

scientific article published on 01 January 1997

Signaling by sensory receptors

scientific article

Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina

scientific article published on 2 December 2015

Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments ⬇️

scientific article published on September 1, 1997

Structure of the RECK CC domain, an evolutionary anomaly

scientific article published on 15 June 2020

Structure-function analysis of the bestrophin family of anion channels

scientific article

The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease

scientific article

The evolution of Primate color vision

scientific article

The genomic response of the retinal pigment epithelium to light damage and retinal detachment

scientific article published on September 2008

The optokinetic reflex as a tool for quantitative analyses of nervous system function in mice: application to genetic and drug-induced variation

scientific article

The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes.

scientific article

The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

scientific journal article

The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling

scientific article

The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation

scientific article published on 28 October 2015

The vitelliform macular dystrophy protein defines a new family of chloride channels

scientific article

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

scientific article published on 8 June 2015

Tissue/planar cell polarity in vertebrates: new insights and new questions

scientific article published on February 2007

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

scientific article published on 06 September 2018

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

scientific article

Visual pigments and inherited variation in human vision

scientific article published on January 1, 1992

When whorls collide: the development of hair patterns in frizzled 6 mutant mice

scientific article published on December 2010

Written in our genes?

scientific article

List of works by Jeremy Nathans

A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.

A strabismus susceptibility locus on chromosome 7p

A visual pigment from chicken that resembles rhodopsin: amino acid sequence, gene structure, and functional expression

Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation

Absorption spectra of the hybrid pigments responsible for anomalous color vision

Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions

An MRI-based atlas and database of the developing mouse brain

An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus.

An essential role for frizzled 5 in mammalian ocular development

An evolutionary perspective on the photoreceptor damage response.

An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase.

Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling

Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling.

Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

Bovine pancreatic trypsin inhibitor-trypsin complex as a detection system for recombinant proteins ⬇️

Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells ⬇️

Ca2+-activated Cl- current from human bestrophin-4 in excised membrane patches

Canonical WNT signaling components in vascular development and barrier formation

Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura

China's Plan Flawed But Courageous ⬇️

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function

Climate change and the integrity of science

Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone ⬇️

Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis

Complete morphologies of basal forebrain cholinergic neurons in the mouse

Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing

Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis

Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

Effects of L1 retrotransposon insertion on transcript processing, localization and accumulation: lessons from the retinal degeneration 7 mouse and implications for the genomic ecology of L1 elements

Emergence of novel color vision in mice engineered to express a human cone photopigment

Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain

Epigenomic landscapes of retinal rods and cones

Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development ⬇️

Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis

Expression of the Norrie disease gene (Ndp) in developing and adult mouse eye, ear, and brain

Flat mount imaging of mouse skin and its application to the analysis of hair follicle patterning and sensory axon morphology

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes

Frizzled Receptors in Development and Disease

Frizzled-3 is required for the development of major fiber tracts in the rostral CNS.

Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system

Frizzled6 controls hair patterning in mice

Functional assembly of accessory optic system circuitry critical for compensatory eye movements

Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse

Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision

Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology

Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling

Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II

How scientists can reduce their carbon footprint

How to draw the line in biomedical research

Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression ⬇️

Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution

Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C (rdgC) ⬇️

Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles

Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance.

Intramembrane Proteolysis of Astrotactins

Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin ⬇️

Macular degeneration: recent advances and therapeutic opportunities.

Mechanisms of spectral tuning in the mouse green cone pigment ⬇️

Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.

Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound

Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling

Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: Analysis of wild type and mutant cells using genetically-directed sparse labeling ⬇️

Mutational analysis of Norrin-Frizzled4 recognition

New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling

Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization

Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity

Order from disorder: Self-organization in mammalian hair patterning

Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance

Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling

Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium

Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium ⬇️