List of works - Brant E Isakson

'Gaps' in targeted ischaemic injury therapies in ST-elevation myocardial infarction

A Cell Culture Model of Resistance Arteries

scientific article published on 8 September 2017

A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells

scientific article

A new method for in vivo visualization of vessel remodeling using a near-infrared dye.

scientific article

A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction

scientific article

AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus

scientific article

Biological and biophysical properties of vascular connexin channels

scientific article

Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction

scientific article

Cardiac MR detects the progression of impaired myocardial perfusion reserve in a mouse model of obesity-related cardiomyopathy

scientific article

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet

scientific article

Characterization of the thoracodorsal artery: morphology and reactivity

scientific article

Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall

scientific article

Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation

scientific article

Connexins in vascular physiology and pathology

scientific article

Connexins, pannexins and innexins: protein cousins with overlapping functions

scientific article

Connexins: gaps in our knowledge of vascular function

scientific article

Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

scientific article published on February 2016

Differentiating connexin hemichannels and pannexin channels in cellular ATP release

scientific article

Diverse post-translational modifications of the pannexin family of channel-forming proteins

scientific article

Emerging concepts regarding pannexin 1 in the vasculature

scientific article

Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone

scientific article published on 22 March 2018

Endothelial cell expression of haemoglobin α regulates nitric oxide signalling

scientific article

Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility

Endothelial nitric oxide synthase in the microcirculation

scientific article

Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function

scientific article published in June 2010

Epithelial and Endothelial Pannexin1 Channels Mediate AKI

article published in 2018

Expression of pannexin isoforms in the systemic murine arterial network

scientific article

Extracellular matrix-driven alveolar epithelial cell differentiation in vitro

scientific article

Hemoglobin α in the blood vessel wall

scientific article

Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction

scientific article

Heterocellular contact at the myoendothelial junction influences gap junction organization

scientific article

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

scientific article

Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation

scientific article

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

scientific article

Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells

scientific article

Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication

scientific article

Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction

scientific article

Loss of compliance in small arteries, but not in conduit arteries, after 6 weeks exposure to high fat diet

scientific article

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

scientific article

Mechanisms of ATP release and signalling in the blood vessel wall

scientific article

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).

scientific article

Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries

scientific article published on 23 December 2017

Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function

scientific article published on 9 November 2017

On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability.

scientific article

Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation

scientific article

Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication

scientific article

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone

scientific article published on 13 December 2017

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis

scientific article

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

scientific article

Pannexin 1 in the regulation of vascular tone

scientific article

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

scientific article

Pannexin channel and connexin hemichannel expression in vascular function and inflammation

scientific article

Pannexin-1 as a potentiator of ligand-gated receptor signaling

scientific article

Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury

Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction

scientific article

Plasminogen activator inhibitor-1 regulates myoendothelial junction formation

scientific article

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway

scientific article published on 30 August 2017

Posttranslational modifications in connexins and pannexins

scientific article

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

scientific article

Regulation of cellular communication by signaling microdomains in the blood vessel wall

scientific article

Replacement Therapies in Metabolic Disease

Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone"

S-nitrosylation inhibits pannexin 1 channel function

scientific article

Secreting von Willebrand factor in a Gα-SNAP.

scientific article

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries

scientific article published on 09 February 2017

Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endothelium

scientific article

Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells

scientific article

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions

scientific article

Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice

scientific article

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43

scientific article

TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction

scientific article published on 4 January 2018

The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature

scientific article

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration

scientific article

The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating

scientific article

The myoendothelial junction: breaking through the matrix?

scientific article

The myoendothelial junction: connections that deliver the message.

scientific article

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition

scientific article

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

scientific article published on 01 September 2018

Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1

scientific article

Vascular gap junctions in hypertension

scientific article published on 2 October 2006

ZP1609/Danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design

scientific article

List of works by Brant E Isakson

'Gaps' in targeted ischaemic injury therapies in ST-elevation myocardial infarction

A Cell Culture Model of Resistance Arteries

A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells

A new method for in vivo visualization of vessel remodeling using a near-infrared dye.

A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction

AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus

Biological and biophysical properties of vascular connexin channels

Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction

Cardiac MR detects the progression of impaired myocardial perfusion reserve in a mouse model of obesity-related cardiomyopathy

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet

Characterization of the thoracodorsal artery: morphology and reactivity

Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall

Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation

Connexins in vascular physiology and pathology

Connexins, pannexins and innexins: protein cousins with overlapping functions

Connexins: gaps in our knowledge of vascular function

Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

Differentiating connexin hemichannels and pannexin channels in cellular ATP release

Diverse post-translational modifications of the pannexin family of channel-forming proteins

Emerging concepts regarding pannexin 1 in the vasculature

Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone

Endothelial cell expression of haemoglobin α regulates nitric oxide signalling

Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility

Endothelial nitric oxide synthase in the microcirculation

Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function

Epithelial and Endothelial Pannexin1 Channels Mediate AKI

Expression of pannexin isoforms in the systemic murine arterial network

Extracellular matrix-driven alveolar epithelial cell differentiation in vitro

Hemoglobin α in the blood vessel wall

Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction

Heterocellular contact at the myoendothelial junction influences gap junction organization

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells

Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication

Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction

Loss of compliance in small arteries, but not in conduit arteries, after 6 weeks exposure to high fat diet

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

Mechanisms of ATP release and signalling in the blood vessel wall

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).

Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries

Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function

On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability.

Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation

Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

Pannexin 1 in the regulation of vascular tone

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Pannexin channel and connexin hemichannel expression in vascular function and inflammation

Pannexin-1 as a potentiator of ligand-gated receptor signaling

Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury

Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction

Plasminogen activator inhibitor-1 regulates myoendothelial junction formation

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway

Posttranslational modifications in connexins and pannexins

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

Regulation of cellular communication by signaling microdomains in the blood vessel wall

Replacement Therapies in Metabolic Disease

Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone"

S-nitrosylation inhibits pannexin 1 channel function

Secreting von Willebrand factor in a Gα-SNAP.

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries

Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endothelium

Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions

Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43

TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction

The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration

The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating

The myoendothelial junction: breaking through the matrix?

The myoendothelial junction: connections that deliver the message.

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1