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List of works by Laura C Greaves

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices

scientific article published on 28 May 2019

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

scientific article published on September 2016

A methodological approach to tracing cell lineage in human epithelial tissues

scientific article published on June 2009

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

scientific article published on 16 April 2018

Aberrant mitochondrial function in ageing and cancer

scientific article published on 04 December 2019

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis

scientific article published on 21 September 2020

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

scientific article

Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy

scientific article

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

scientific article

Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.

scientific article

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

scientific article

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations

scientific article

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

scientific article

Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up

scientific article published on 02 August 2019

Detection of cytochrome c oxidase activity and mitochondrial proteins in single cells

scientific article published on 31 August 2009

Differences in the accumulation of mitochondrial defects with age in mice and humans

scientific article published on 12 October 2011

Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk

scientific article published on 22 March 2019

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

scientific article

Impact of age-related mitochondrial dysfunction and exercise on intestinal microbiota composition

scientific article

In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells.

scientific article

Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

scientific article published on 05 November 2018

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

scientific article published on 08 February 2019

Locating the stem cell niche and tracing hepatocyte lineages in human liver

scientific article

Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells

scientific article

Mitochondria are required for pro-ageing features of the senescent phenotype.

scientific article

Mitochondrial DNA and disease

scientific article published on 21 November 2011

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease.

scientific article published on 17 November 2017

Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO.

scientific article

Mitochondrial DNA mutations and aging.

scientific article published on April 2007

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

scholarly article

Mitochondrial DNA mutations in human colonic crypt stem cells

scientific article published on November 2003

Mitochondrial DNA mutations in human disease

scientific article published on 01 March 2006

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

scientific article published on 15 July 2020

Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: link to colon cancer?

scholarly article

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

scientific article published on August 2017

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.

scientific article

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

scientific article

Quantification of mitochondrial DNA mutation load

scientific article published on 18 July 2009

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing.

scientific article published on 27 March 2018

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

scientific article

Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles

scientific article

The ageing mitochondrial genome

scientific article

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease.

scientific article published on 5 September 2015

The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential.

scientific article

Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(-/-) mice

scientific article published on 24 August 2016

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