List of works - Gilles Truan

A combinatorial approach to substrate discrimination in the P450 CYP1A subfamily

scientific article

A single-step procedure of recombinant library construction for the selection of efficiently produced llama VH binders directed against cancer markers.

scientific article

A well-balanced preexisting equilibrium governs electron flux efficiency of a multidomain diflavin reductase.

scientific article published on March 2015

Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes.

scientific article published on 18 December 2014

Accurate Determination of Human CPR Conformational Equilibrium by smFRET Using Dual Orthogonal Noncanonical Amino Acid Labeling

scientific article published on 23 January 2019

An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase

scientific article published on 01 January 1997

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain.

scientific article published on May 1994

Cloning, purification, crystallization and preliminary X-ray analysis of a chimeric NADPH-cytochrome P450 reductase.

scientific article published on 12 February 2009

Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength.

scientific article

Dynamic control of electron transfers in diflavin reductases.

scientific article published on 15 November 2012

Dynamics of α-Hb chain binding to its chaperone AHSP depends on heme coordination and redox state.

scientific article published on 21 September 2013

Engineered yeasts simulating P450-dependent metabolisms: tricks, myths and reality.

scientific article

Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human cytochrome b5.

scientific article published on March 1993

Enzyme-fusion strategies for redirecting and improving carotenoid synthesis in

scientific article published on 18 January 2019

Exploration of Natural and Artificial Sequence Spaces: Towards a Functional Remodeling of Membrane-bound Cytochrome P450

Functional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

scientific article published on 21 August 2019

Functional analysis of yeast bcs1 mutants highlights the role of Bcs1p-specific amino acids in the AAA domain.

scientific article published on 13 March 2009

Gene2Oligo: oligonucleotide design for in vitro gene synthesis.

scientific article published on July 2004

High efficiency family shuffling based on multi-step PCR and in vivo DNA recombination in yeast: statistical and functional analysis of a combinatorial library between human cytochrome P450 1A1 and 1A2

scientific article

High-throughput enzymology and combinatorial mutagenesis for mining cytochrome P450 functions

scientific article published on 01 June 2008

High-throughput functional screening of steroid substrates with wild-type and chimeric P450 enzymes.

scientific article published on 26 August 2014

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

scientific article published in 2018

Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding

scientific article published on 11 September 2020

Ligand Access Channels in Cytochrome P450 Enzymes: A Review.

scientific article published on 30 May 2018

Microarray-based method for combinatorial library sequence mapping and characterization.

scientific article

NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: insight into its biological role

scientific article

Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

scientific article published on 11 October 2019

Ordered chimerogenesis applied to CYP2B P450 enzymes

scientific article published on 22 March 2016

P450BM-3: absolute configuration of the primary metabolites of palmitic acid

scientific article published on 01 June 1999

P450BM-3; a tale of two domains--or is it three?

scientific article

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450

scientific article published on 06 December 2018

Producing chimeric genes by CLERY: in vitro and in vivo recombination

article

Recombinant yeast in drug metabolism.

scientific article published on October 1993

Reconstitution of the fatty acid hydroxylase activity of cytochrome P450BM-3 utilizing its functional domains

scientific article published on 01 April 1997

Role of the interface between the FMN and FAD domains in the control of redox potential and electronic transfer of NADPH-cytochrome P450 reductase

scientific article published on 01 April 2011

Sequence mapping of combinatorial libraries on macro- and microarrays: bioinformatic treatment of data.

scientific article

Sequence mapping of combinatorial libraries on macro- or microarrays: experimental design of DNA arrays.

scientific article

Simulation of human xenobiotic metabolism in microorganisms. Yeast a good compromise between E. coli and human cells.

scientific article

Spontaneous non-canonical assembly of CcmK hexameric components from β-carboxysome shells of cyanobacteria

scientific article published on 21 September 2017

Synthetic Derivatives of (+)-epi-α-Bisabolol Are Formed by Mammalian Cytochromes P450 Expressed in a Yeast Reconstituted Pathway

scientific article published on 04 February 2020

The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength

scientific article published on 30 October 2017

The Promise of Optogenetics for Bioproduction: Dynamic Control Strategies and Scale-Up Instruments

scientific article published on 24 November 2020

The closed and compact domain organization of the 70-kDa human cytochrome P450 reductase in its oxidized state as revealed by NMR.

scientific article published on 26 April 2012

The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3

scientific article published in 1996

Thr268 in substrate binding and catalysis in P450BM-3

scientific article published on 01 January 1998

Transcription interference and ORF nature strongly affect promoter strength in a reconstituted metabolic pathway

scientific article

Xenobiotic metabolism in humanized yeast: engineered yeast cells producing human NADPH-cytochrome P-450 reductase, cytochrome b5, epoxide hydrolase and P-450s.

scientific article published on November 1993

List of works by Gilles Truan

A combinatorial approach to substrate discrimination in the P450 CYP1A subfamily

A single-step procedure of recombinant library construction for the selection of efficiently produced llama VH binders directed against cancer markers.

A well-balanced preexisting equilibrium governs electron flux efficiency of a multidomain diflavin reductase.

Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes.

Accurate Determination of Human CPR Conformational Equilibrium by smFRET Using Dual Orthogonal Noncanonical Amino Acid Labeling

An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain.

Cloning, purification, crystallization and preliminary X-ray analysis of a chimeric NADPH-cytochrome P450 reductase.

Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength.

Dynamic control of electron transfers in diflavin reductases.

Dynamics of α-Hb chain binding to its chaperone AHSP depends on heme coordination and redox state.

Engineered yeasts simulating P450-dependent metabolisms: tricks, myths and reality.

Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human cytochrome b5.

Enzyme-fusion strategies for redirecting and improving carotenoid synthesis in

Exploration of Natural and Artificial Sequence Spaces: Towards a Functional Remodeling of Membrane-bound Cytochrome P450

Functional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

Functional analysis of yeast bcs1 mutants highlights the role of Bcs1p-specific amino acids in the AAA domain.

Gene2Oligo: oligonucleotide design for in vitro gene synthesis.

High efficiency family shuffling based on multi-step PCR and in vivo DNA recombination in yeast: statistical and functional analysis of a combinatorial library between human cytochrome P450 1A1 and 1A2

High-throughput enzymology and combinatorial mutagenesis for mining cytochrome P450 functions

High-throughput functional screening of steroid substrates with wild-type and chimeric P450 enzymes.

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding

Ligand Access Channels in Cytochrome P450 Enzymes: A Review.

Microarray-based method for combinatorial library sequence mapping and characterization.

NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: insight into its biological role

Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

Ordered chimerogenesis applied to CYP2B P450 enzymes

P450BM-3: absolute configuration of the primary metabolites of palmitic acid

P450BM-3; a tale of two domains--or is it three?

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450

Producing chimeric genes by CLERY: in vitro and in vivo recombination

Recombinant yeast in drug metabolism.

Reconstitution of the fatty acid hydroxylase activity of cytochrome P450BM-3 utilizing its functional domains

Role of the interface between the FMN and FAD domains in the control of redox potential and electronic transfer of NADPH-cytochrome P450 reductase

Sequence mapping of combinatorial libraries on macro- and microarrays: bioinformatic treatment of data.

Sequence mapping of combinatorial libraries on macro- or microarrays: experimental design of DNA arrays.

Simulation of human xenobiotic metabolism in microorganisms. Yeast a good compromise between E. coli and human cells.

Spontaneous non-canonical assembly of CcmK hexameric components from β-carboxysome shells of cyanobacteria

Synthetic Derivatives of (+)-epi-α-Bisabolol Are Formed by Mammalian Cytochromes P450 Expressed in a Yeast Reconstituted Pathway

The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength

The Promise of Optogenetics for Bioproduction: Dynamic Control Strategies and Scale-Up Instruments

The closed and compact domain organization of the 70-kDa human cytochrome P450 reductase in its oxidized state as revealed by NMR.

The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3

Thr268 in substrate binding and catalysis in P450BM-3

Transcription interference and ORF nature strongly affect promoter strength in a reconstituted metabolic pathway

Xenobiotic metabolism in humanized yeast: engineered yeast cells producing human NADPH-cytochrome P-450 reductase, cytochrome b5, epoxide hydrolase and P-450s.