List of works - John Miles

A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism

scientific article

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

scientific article

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

scientific article

A primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics

scientific article published on 23 November 2020

A single autoimmune T cell receptor recognizes more than a million different peptides

scientific article published on 18 November 2011

Advances in T-cell epitope engineering

scientific article published on 5 June 2013

Allelic polymorphism in the T cell receptor and its impact on immune responses

scientific article

Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry

scientific article published on 8 September 2006

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant

scientific article

Anomalies in T Cell Function Are Associated With Individuals at Risk of Mycobacterium abscessus Complex Infection.

scientific article

Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection

scientific article

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

scientific article

Antibody response to common human viruses is shaped by genetic factors

scientific article published on 20 December 2018

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

scientific article

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection

scientific article published on 15 December 2010

Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination

scientific article published on 08 February 2011

Bone marrow transplantation generates T cell-dependent control of myeloma in mice

scientific article published on 19 November 2018

CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope

scientific article

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

scientific article published on 22 May 2014

CD8+ TCR Repertoire Formation Is Guided Primarily by the Peptide Component of the Antigenic Complex

scientific article published on 24 December 2012

CTL recognition of a bulged viral peptide involves biased TCR selection

scientific article published in September 2005

Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution

scientific article published on 8 June 2016

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

scientific article

Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media ⬇️

scientific article published on October 7, 2010

Differential pulsatile secretagogue control of GH secretion in healthy men ⬇️

scientific article published on March 13, 2013

Diversity of Rhizoctonia spp. Causing Foliar Blight on Brachiaria in Colombia and Evaluation of Brachiaria Genotypes for Foliar Blight Resistance

scientific article published on 01 June 2013

Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1.

scientific article

Engineered T cell receptors and their potential in molecular medicine

scientific article published on January 2006

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

scientific article published on 15 June 2016

Erratum: Tracking the T-cell repertoire after adoptive therapy

scientific article published on 26 May 2017

Exploring immunomodulation by endocrine changes in Lady Windermere syndrome

scientific article published on 27 February 2019

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

scientific article

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

scientific article

Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation

scientific article published on 01 August 2018

Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells.

scientific article

HLA peptide length preferences control CD8+ T cell responses

scientific article

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

scientific article

Helminth Immunomodulation in Autoimmune Disease

scientific article

High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover

scientific article

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance

scientific article

Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I Molecule

scientific article

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

scientific article published on 25 March 2019

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

scientific article published on 16 May 2016

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

scientific article published on 15 August 2016

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting

scientific article

Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo

scientific article published on 30 October 2017

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling

scientific article published on January 2013

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

scientific article published on 5 February 2016

Immune drug discovery from venoms.

scientific article published on 20 November 2017

Immune parameters to consider when choosing T-cell receptors for therapy

scientific article published on 5 August 2013

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

scientific article

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection

scientific article

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

scientific article

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

scientific article published on 26 February 2010

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

scientific article

Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients

scientific article published on 10 August 2016

Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.

scientific article

Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire

article

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

scientific article

Molecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell Repertoire

scientific article published on 10 February 2014

Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

scientific article published on 12 September 2016

Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood

scientific article published on 05 February 2014

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

scientific article

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

scientific article

Peptide length determines the outcome of TCR/peptide-MHCI engagement

scientific article

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

scientific article published on 12 March 2018

Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis

scientific article

Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length

scientific article published on September 2004

Predictable alphabeta T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope

scientific article published on 25 April 2007

Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition

scientific article published on 5 November 2007

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity

scientific article published on August 2016

Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype

scientific article

Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients.

scientific article published on 24 August 2016

Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis).

scientific article published on 15 January 2018

Reactivated CD4+Tm cells of T1D patients and siblings display an exaggerated effector phenotype with heightened sensitivity to activation-induced cell death

scientific article published on 31 December 2014

Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism

scientific article published in Nature Communications

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

scientific article

Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study

scientific article published on 17 December 2018

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies

scientific article published on 08 December 2018

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

scientific article

Structural and biophysical determinants of αβ T-cell antigen recognition

scientific article published on January 2012

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

scientific article

Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy

scientific article published on 19 January 2016

Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery.

scientific article published on March 2013

Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo

scientific article published in 2021

T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells

scientific article

T cell antigen receptor recognition of antigen-presenting molecules

scientific article published on 10 December 2014

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

scientific article published on 12 March 2018

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

scientific article published on 25 September 2005

T-cell Receptor Specificity Maintained by Altered Thermodynamics

scientific article

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

scientific article

T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years

scientific article

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

scientific article published on 27 January 2016

TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope

scientific article published on November 2006

TCR deep sequencing of transgenic RAG-1-deficient mice reveals endogenous TCR recombination: a cause for caution.

scientific article published on 24 March 2018

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

article

The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells

scientific article published on 17 October 2018

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

scientific article

The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV

article

The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity

scientific article

Tracking the T-cell repertoire after adoptive therapy

scientific article published on 5 May 2017

Tracking the repertoire of human adult and neonatal T cells during ex vivo amplification

scientific article

Understanding the complexity and malleability of T-cell recognition

scientific article published on 13 January 2015

Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

scientific article published in June 2008

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

scientific article

List of works by John Miles

A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

A primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics

A single autoimmune T cell receptor recognizes more than a million different peptides

Advances in T-cell epitope engineering

Allelic polymorphism in the T cell receptor and its impact on immune responses

Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant

Anomalies in T Cell Function Are Associated With Individuals at Risk of Mycobacterium abscessus Complex Infection.

Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

Antibody response to common human viruses is shaped by genetic factors

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection

Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination

Bone marrow transplantation generates T cell-dependent control of myeloma in mice

CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

CD8+ TCR Repertoire Formation Is Guided Primarily by the Peptide Component of the Antigenic Complex

CTL recognition of a bulged viral peptide involves biased TCR selection

Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media ⬇️

Differential pulsatile secretagogue control of GH secretion in healthy men ⬇️

Diversity of Rhizoctonia spp. Causing Foliar Blight on Brachiaria in Colombia and Evaluation of Brachiaria Genotypes for Foliar Blight Resistance

Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1.

Engineered T cell receptors and their potential in molecular medicine

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

Erratum: Tracking the T-cell repertoire after adoptive therapy

Exploring immunomodulation by endocrine changes in Lady Windermere syndrome

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation

Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells.

HLA peptide length preferences control CD8+ T cell responses

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Helminth Immunomodulation in Autoimmune Disease

High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance

Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I Molecule

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting

Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

Immune drug discovery from venoms.

Immune parameters to consider when choosing T-cell receptors for therapy

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients

Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.

Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

Molecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell Repertoire

Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Peptide length determines the outcome of TCR/peptide-MHCI engagement

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis

Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length

Predictable alphabeta T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope

Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity

Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype

Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients.

Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis).

Reactivated CD4+Tm cells of T1D patients and siblings display an exaggerated effector phenotype with heightened sensitivity to activation-induced cell death

Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies