List of works - Stephen B Shears

A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

scientific article

A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging

article

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA ⬇️

scientific article published on November 30, 2012

A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis ⬇️

scientific article published on 06 February 2013

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

scientific article published on 25 April 2022

Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

scientific article published on December 2012

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

scientific article published on 27 November 2020

Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells ⬇️

scientific article published on October 15, 1997

Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling

scientific article published on 04 February 2020

Defining Signal Transduction by Inositol Phosphates ⬇️

scientific article published on January 1, 2012

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase ⬇️

scientific article published on November 28, 2012

HIV‐1 envelope protein, gp120, has no effects on inositol phosphate production and metabolism in the Jurkat T‐cell line either in the presence or absence of receptor stimulation ⬇️

scientific article published on August 11, 1997

How versatile are inositol phosphate kinases? ⬇️

scientific article published on January 15, 2004

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response

scientific article (publication date: February 2014)

Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis

scientific article published on 25 January 2019

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells

scientific article published on 6 March 2018

InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

scientific article published on 29 July 2020

Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.

scientific article

Ion transport in liver mitochondria from normal and thyroxine-treated rats ⬇️

scientific article published on December 1, 1980

Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase ⬇️

scientific article published on November 15, 1997

Multiple isomers of inositol pentakisphosphate in Epstein-Barr-virus- transformed (T5-1) B-lymphocytes. Identification of inositol 1,3,4,5,6-pentakisphosphate, d-inositol 1,2,4,5,6-pentakisphosphate and l-inositol 1,2,4,5,6-pentakisphosphate ⬇️

scientific article published on December 1, 1991

Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases ⬇️

scientific article published on July 1, 2003

Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP<sub>8</sub> induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode

scientific article published on 08 September 2020

Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain ⬇️

scientific article published on March 15, 2011

Regulation of Ca2+‐dependent Cl− conductance in a human colonic epithelial cell line (T84): cross‐talk between Ins(3,4,5,6)P4 and protein phosphatases ⬇️

scientific article published on August 1, 1998

Regulation of the metabolism of 1,2-diacylglycerols and inositol phosphates that respond to receptor activation

scientific article published on January 1, 1991

Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells ⬇️

scientific article published on June 1, 1992

Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver ⬇️

scientific article published on November 22, 1984

Structural insight into inositol pyrophosphate turnover ⬇️

scientific article published on October 11, 2012

Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7

scientific article published on 07 June 2019

The effects of thyroxine treatment, in vivo and in vitro, on Ca2+efflux from rat liver mitochondria ⬇️

scientific article published on 01 April 1981

The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase ⬇️

scientific article published on November 1, 2003

The influence of thyroxine administered in vivo on the transmembrane protonic electrochemical potential difference in rat liver mitochondria ⬇️

scientific article published on February 15, 1979

The interaction of coatomer with inositol polyphosphates is conserved in Saccharomyces cerevisiae ⬇️

scientific article published on August 15, 1995

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment ⬇️

scientific article published on February 5, 2013

The mitochondrial protonic electrochemical potential difference as a point of hormone action. II. New proposals for the activity of glucagon ⬇️

scientific article published on 01 July 1981

Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta 2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism ⬇️

scientific article published on March 16, 1998

Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors

article published in 2018

d - myo -Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways ⬇️

scientific article published on December 23, 1997

List of works by Stephen B Shears