List of works by Carla Ghelardini

2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.

scientific article published on 7 March 2013

2-pyrrolidinone moiety is not critical for the cognition-enhancing activity of piracetam-like drugs

scientific article published in September 2003

3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.

scientific article

3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies

scientific article published on 4 June 2012

4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.

scientific article

4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action

scientific article

4-methyl benzylamine stimulates food consumption and counteracts the hypophagic effects of amphetamine acting on brain Shaker-like Kv1.1 channels

scientific article published on January 2006

6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells

scientific article

A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain

scientific article published on January 2013

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

scientific article published on 26 April 2013

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

scientific article

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice

scientific article published on 17 July 2008

A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam.

scientific article

A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury

scientific article published on November 2009

A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin

scientific article published on 12 October 2017

A recombinant transductor-effector system: in vitro study of G inhibitory protein (G-alpha-i1) direct activators

scientific article published on 2 August 2006

A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages

scientific article published on 8 April 2014

AG-4: a nicotinic agonist endowed with antiamnesic properties

scientific article

Acetyl-L-carnitine in the management of pain during methadone withdrawal syndrome.

scientific article

Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception

scientific article

Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats

scientific article published on December 2002

Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia.

scientific article

Activity and expression of semicarbazide-sensitive benzylamine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-aminoguanidine

scientific article published in December 2005

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats

scholarly article by Laura Micheli et al published May 2015 in European Journal of Pharmacology

Acute effect of Capparis spinosa root extracts on rat articular pain.

scientific article published on 16 September 2016

Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation

scientific article published on 11 December 2017

Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype

scientific article

Alpha2-agonists as analgesic agents.

scientific article published on March 2009

Altered Expression of Cytoskeletal and Axonal Proteins in Oxaliplatin-Induced Neuropathy

scientific article published on 29 January 2016

Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity versus Pathogenic Yeasts

scientific article published on 05 March 2012

Amitriptyline and clomipramine activate Gi-protein signaling pathway in the induction of analgesia.

scientific article

Analgesic and antineuropathic drugs acting through central cholinergic mechanisms

scientific article published on May 2011

Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors

scientific article published on 07 October 2016

Antiamnesic effect of the two novel ?-opioid agonists, VA-100 and VA-101, in the mouse passive avoidance test

Antidepressant phenotype by inhibiting the phospholipase Cβ(1)--protein kinase Cγ pathway in the forced swim test

scientific article published on 28 January 2011

Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression

scientific article published on 18 May 2011

Antihyperalgesic activity of verbascoside in two models of neuropathic pain.

scientific article

Antineuropathic profile of N-palmitoylethanolamine in a rat model of oxaliplatin-induced neurotoxicity

scientific article

Antinociceptive profile of the natural cholinesterase inhibitor huperzine A

Antinociceptive profile of the new nicotinic agonist DBO-83

Antinociceptive property of the nicotinic agonist AG-4 in rodents

Antisense knockdown of the Shaker-like Kv1.1 gene abolishes the central stimulatory effects of amphetamines in mice and rats

scientific article published on 9 April 2003

Apoptotic Process Induced by Oxaliplatin in Rat Hippocampus Causes Memory Impairment

scientific article published on 6 June 2016

Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.

scientific article published in December 2006

Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

scientific article published on 10 February 2017

Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation

scientific article published on 14 September 2016

BDNF and Artemin are increased in drug-naïve non-depressed GAD patients: preliminary data

scientific article

Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions

scientific article published on 26 November 2016

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

scientific article published on 21 May 2019

Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis

scientific article published on 15 November 2019

Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test

scientific article

Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain

scientific article

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1.

scientific article

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

scientific article published in August 2017

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors.

scientific article published on 26 November 2015

Central muscarinic antinociception induced by ET-142 and SS-20 in rodents

Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo).

scientific article

Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity

scientific article published in May 2010

Combined Approach of Cyclodextrin Complexationand Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide

article

Contribution of G inhibitory protein alpha subunits in paradoxical hyperalgesia elicited by exceedingly low doses of morphine in mice

scientific article

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity

scientific article

Delay of morphine tolerance by palmitoylethanolamide

scientific article published on 22 March 2015

Design and Study of Piracetam-like Nootropics, Controversial Members of the Problematic Class of Cognition-Enhancing Drugs

scientific article (publication date: 2002)

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis

scientific article published on 11 January 2017

Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors

scientific article published on 16 March 2016

Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands

scientific article published on 12 September 2007

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

scientific article published on 09 April 2018

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects

scientific article published on 19 May 2018

Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers

scientific article published on 3 September 2009

Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators

scientific article

Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers.

scientific article

Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain

scientific article

Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins

scientific article

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

scientific article

Development and characterization of fast dissolving tablets of oxaprozin based on hybrid systems of the drug with cyclodextrins and nanoclays.

scientific article published on 15 May 2017

Development and characterization of niosomal formulations of doxorubicin aimed at brain targeting

scientific article published on January 2012

Development and in vivo evaluation of an innovative "Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles" formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics

scientific article published on 13 February 2017

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain

article published in 2018

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain

scholarly article by Margherita Brindisi et al published 30 August 2018 in ChemMedChem

Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief

scientific article

Development, characterization and in vivo evaluation of benzocaine-loaded liposomes.

scientific article published on 12 February 2007

Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells

scientific article

Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes

scientific article published on 25 April 2008

Differential contribution of Gαi/o subunits in the response to food deprivation

scientific article published on 22 January 2015

Differentiation state affects morphine induced cell regulation in neuroblastoma cultured cells

scientific article published on 6 August 2013

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

scientific article published on 10 August 2017

Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.

scientific article published on 21 November 2017

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis

scientific article published on 21 May 2018

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity

scientific article published on 03 September 2018

Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo

scientific article

Dual effect of morphine in long-term social memory in rat.

scientific article published on April 2013

Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence

scientific article published in Scientific Reports

Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression

scientific article published on 3 November 2016

Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes

scientific article published in January 2009

Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy

scientific article published on 28 January 2016

Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations

scientific article

Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats

scientific article published on 21 August 2017

Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats

scientific article published on 14 January 2010

Effects of endogenous morphine deprivation on memory retention of passive avoidance learning in mice

scientific article

Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels

scientific article published on 18 April 2017

Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent

scientific article

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

scientific article published on 18 December 2013

Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet

scientific article published on 03 November 2020

Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent

scientific article published on 19 July 2008

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

scientific article

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

scientific article published on 12 October 2014

Gi/o proteins: expression for direct activation enquiry

scientific article published on 5 December 2005

Glial role in oxaliplatin-induced neuropathic pain

scientific article published on 23 June 2014

H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway

scientific article

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines

scientific article published on 29 August 2018

Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation.

scientific article published in December 2015

Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress

scientific article published on 7 October 2016

HuD-mediated distinct BDNF regulatory pathways promote regeneration after nerve injury

scientific article published on 19 January 2017

Improvement of cognitive functions by the acetylcholine releaser SM 21

In Vitro Evidence for the Use of Astragali Radix Extracts as Adjuvant against Oxaliplatin-Induced Neurotoxicity

scientific article published on 3 June 2015

Inactivation of Gi proteins induces an antidepressant-like effect in the mouse forced-swimming test

scientific article

Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine

scientific article published in October 2004

Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.

scientific article published in September 2002

Inhibition of spinal ERK1/2-c-JUN signaling pathway counteracts the development of low doses morphine-induced hyperalgesia

scientific article published on 9 July 2015

Inhibition of the PKCγ-ε pathway relieves from meningeal nociception in an animal model: an innovative perspective for migraine therapy?

scientific article

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

scientific article published on 21 February 2017

Injectable liposomal formulations of opiorphin as a new therapeutic strategy in pain management

scientific article

Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity

scientific article published on 5 October 2015

Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad?

scientific article published on 26 January 2018

Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation

scientific article

Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain.

scientific article published on 6 January 2015

Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anesthetic efficacy

scientific article published on 28 January 2010

Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).

scientific article

Low dose native type II collagen prevents pain in a rat osteoarthritis model

scientific article

Menthol: a natural analgesic compound

scientific article (publication date: 12 April 2002)

Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype

scientific article published on 20 April 2004

Methylamine: a new endogenous modulator of neuron firing?

scientific article

Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception.

scientific article

Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain

scientific article

N-Palmitoylethanolamine Supplementation for Long-Lasting, Low-Dosed Morphine Antinociception.

scientific article published in June 2018

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

scientific article published on 06 June 2019

Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor

scientific article published in January 2009

Neurorestoration from medicinal plants: an opportunity to treat painful neuropathies

scientific article published on March 2017

Neurotransmitter role of endogenous morphine in CNS.

scientific article

New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists

scientific article

New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds

scientific article published on 27 July 2011

Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models

scientific article published on 3 May 2013

Nociceptin/orphanin FQ receptor and pain: Feasibility of the fourth opioid family member

scientific article published on 12 August 2015

Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies

scientific article published on 5 March 2008

Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage

scientific article published on 2 February 2007

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

scientific article published on 11 April 2013

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

scientific article published on 31 October 2011

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation

scientific article published in January 2010

Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities

scientific article published in March 2002

Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1.

scientific article published on 10 June 2015

Oxaliplatin neurotoxicity involves peroxisome alterations. PPARγ agonism as preventive pharmacological approach

scientific article

Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin

scientific article

PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior

scientific article published on 21 August 2013

PPAR- γ impairment alters peroxisome functionality in primary astrocyte cell cultures

scientific article published on 04 March 2014

Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat.

scientific article published on 28 July 2017

Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents

scientific article published on 16 February 2017

Pleiotropic effect of histamine H4 receptor modulation in the central nervous system

scientific article

Prochlorperazine induces central antinociception mediated by the muscarinic system

scientific article

Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy

scientific article published on 8 July 2010

Receptor-independent modulation of reconstituted Galpha(i) protein mediated by liposomes.

scientific article published on 29 January 2009

Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation

scientific article published on 20 June 2011

Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: a step toward improving opioid pain therapy

scientific article

Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry.

scientific article published in December 2018

Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets

scientific article published on 20 December 2012

Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine

scientific article

Role of intracellular calcium in acute thermal pain perception

scientific article published in November 2004

Ryanodine receptors are involved in muscarinic antinociception in mice

scientific article published in November 2005

Salvianolic acid B and its liposomal formulations: Anti-hyperalgesic activity in the treatment of neuropathic pain

scientific article published on 04 October 2011

Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline

scientific article published on 22 July 2011

Selenium and zinc: Two key players against cadmium-induced neuronal toxicity

scientific article published on 29 January 2018

Signaling pathway of morphine induced acute thermal hyperalgesia in mice.

scientific article published on 2 May 2006

Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.

scientific article published on 13 August 2014

Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies

scientific article published on 21 January 2017

Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activity

scientific article published on 17 August 2019

St. John's Wort Potentiates anti-Nociceptive Effects of Morphine in Mice Models of Neuropathic Pain

scientific article published on 28 September 2016

St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity

scientific article published on 4 January 2010

St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes

scientific article published on 12 October 2013

Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies

scientific article published in October 2006

Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.

scientific article published on 12 January 2018

Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs

scientific article

Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties

scientific article

Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.

scientific article

Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia

scientific article published on 27 July 2009

Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives

scientific article published on 17 June 2017

Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]nonan-8-ones as Potential Nootropic and Analgesic Drugs

scientific article published on 07 March 2011

Synthesis and Biological Evaluation of Chiral α-Aminoanilides with Central Antinociceptive Activity

scientific article published on 21 March 2007

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis

scientific article published on 23 July 2019

Synthesis and Pharmacological Evaluation of Novel GABAA Subtype Receptor Ligands with Potential Anxiolytic-like and Anti-hyperalgesic Effect

scholarly article by Gabriella Guerrini et al published 11 May 2017 in Journal of Heterocyclic Chemistry

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

scientific article published on 28 December 2015

Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain

scientific article

Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands

scientific article published on 11 February 2017

Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold

scientific article published on 26 September 2011

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

scientific article

Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor

scientific article

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

scientific article published on 05 August 2019

Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues

scientific article

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity

scientific article published on 4 July 2008

Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity

scientific article

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents

scientific article published on 24 July 2008

Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism

scientific article

The Phospholipase C-IP3 Pathway is Involved in Muscarinic Antinociception ⬇️

scientific article published on November 11, 2002

The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor

scientific article published on 30 September 2016

The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model

scientific article

The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats

The pharmacological basis of opioids

scientific article

Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats

scientific article published on 06 June 2013

Treatment with acetyl-L-carnitine exerts a neuroprotective effect in the sciatic nerve following loose ligation: a functional and microanatomical study.

scientific article

Widespread pain reliever profile of a flower extract of Tanacetum parthenium

scientific article published on 27 May 2015

[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents.

scientific article published in March 2003

[35S]GTP gamma S binding studies of amphiphilic drugs-activated Gi proteins: a caveat

scientific article published on 28 February 2009

α-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement

scientific article

α2 Adrenoceptor: a Target for Neuropathic Pain Treatment

scientific article

α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity

scientific article published on 3 June 2015

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