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List of works by Kenta Hara

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

scientific article

A case of elderly onset loss of consciousness due to bacterial meningitis and subsequent vasculitis

scientific article published on July 2008

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

scientific article

Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation ⬇️

scientific article published on April 13, 2011

Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice

scientific article published in April 2010

Biguanide, but not thiazolidinedione, improved insulin resistance in Werner syndrome

scientific article published in January 2010

Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin

scientific article

Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites

scientific journal article

Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro

scientific article (publication date: September 2000)

Cardiac mTOR protects the heart against ischemia-reperfusion injury

scientific article

Characterization of ubiquilin 1, an mTOR-interacting protein

scientific article

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

scientific article

Distinct regulatory mechanism for p70 S6 kinase β from that for p70 S6 kinase α ⬇️

scientific article (publication date: November 2001)

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

scientific article (publication date: 26 November 1999)

Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells

scientific article published on February 2003

Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice

scientific article published in December 2008

Kinase Activities Associated with mTOR ⬇️

scientific article published on January 1, 2004

Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes.

scientific article

Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon

scientific article

Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity

scientific article published on May 2007

Molecular Cloning and Characterization of a Novel p70 S6 Kinase, p70 S6 Kinase β Containing a Proline-rich Region ⬇️

scientific article published on November 13, 1998

Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck

scientific article

Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region

scientific article published on 26 July 2006

One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide

scientific article published on 21 July 2008

Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

scientific article

Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.

scientific article

Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-beta suppress autoimmune diabetes

scientific article published on 3 March 2010

Role of S6K1 in regulation of SREBP1c expression in the liver ⬇️

scientific article (publication date: 26 August 2011)

Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acids ⬇️

scientific article published on July 27, 2011

The dual role of scavenger receptor class A in development of diabetes in autoimmune NOD mice

scientific article

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

scientific article (publication date: 2 May 2003)

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

scientific article

Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia

scientific article

Usefulness of 18F-fluorodeoxyglucose positron emission tomography for diagnosis of asymptomatic giant cell arteritis in a patient with Alzheimer's disease ⬇️

scientific article published on January 1, 2011

[Group B streptococcal vertebral osteomyelitis following superficial suppurative thrombophlebitis].

scientific article published on September 2006

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy ⬇️

scientific article published on September 22, 2010

mTOR complex as an integrating controller of cell growth

scientific article published in August 2003

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

scientific article

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