List of works by Jeffrey Scott Flier

A good night's sleep: future antidote to the obesity epidemic?

scientific article

A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty

scientific article published on April 1997

A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance

scientific article

A transgenic model of visceral obesity and the metabolic syndrome

scientific article

ADD-1 provides major new insight into the mechanism of insulin action

scientific article

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

scientific article

Absence of mutations in the human OB gene in obese/diabetic subjects

scientific article published on May 1996

Academia and industry: allocating credit for discovery and development of new therapies

scientific article published on 20 May 2019

Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the type A and B syndromes.

scientific article published in February 1985

Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor

scientific article

Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice

scientific article published in July 1996

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

scientific article published on 10 July 2015

Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity

scientific article

Adipogenesis and obesity: rounding out the big picture

scientific article published on November 1996

Adipose tissue as an endocrine organ

scientific article (publication date: June 2004)

Adipose tissue as an endocrine organ

scientific article

Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling

scientific article published on 31 August 2009

Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin

scientific article

Adipsin is an adipokine that improves β cell function in diabetes

scientific article

Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve

scientific article published on July 1987

Adipsin: regulation and dysregulation in obesity and other metabolic states

scientific article published on January 1989

Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice

scientific article published on January 1989

AgRP in energy balance: Will the real AgRP please stand up?

scientific article

Alterations in sympathetic nervous system activity do not regulate adipsin gene expression in mice

scientific article published on 01 March 1991

Altered erythrocyte Na+ + K+ pump in adolescent obesity

scientific article published on 01 November 1982

Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues ⬇️

scientific article published on June 1, 1992

An Introduction to Receptors and Receptor Disorders ⬇️

scientific article published on October 1, 1979

Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.

scientific article published in May 1978

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance ⬇️

scientific article published on October 3, 1975

Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus

scientific article

Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes ⬇️

scientific article published on July 1, 1991

Attenuation of leptin and insulin signaling by SOCS proteins

scientific article published on 28 September 2006

Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes ⬇️

scientific article published on October 1, 1977

Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice

scientific article

Big deal about a little insulin

scientific article published on 01 June 1999

Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant

scientific article published on June 1991

Biological activity of nasally administered insulin in normal subjects

scientific article published in March 1990

Brown adipose tissue, beta 3-adrenergic receptors, and obesity

scientific article published on January 1997

C. Ronald Kahn: The Louisville Slugger of metabolic science

scientific article published on 01 December 2019

CELL BIOLOGY: Enhanced: Chewing the Fat--ACC and Energy Balance

scientific article published in Science

Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity.

scientific article

Categorizing biomedical research: the basics of translation

scientific article published on 01 August 2017

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

scientific article published on 29 April 2015

Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain

scientific article published in June 1997

Characteristics of in vitro steroidogenesis in a woman with hyperandrogenism, a granulosa cell tumor and polycystic ovary disease. A case report

scientific article published on 01 April 1988

Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat ⬇️

scientific article published on November 1, 1995

Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man ⬇️

scientific article published on December 1, 1976

Characterization of binding and phosphorylation defects of erythrocyte insulin receptors in the type A syndrome of insulin resistance

scientific article

Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice

scientific article

Characterization of insulin-like growth factor binding to human granulosa cells obtained during in vitro fertilization

scientific article published on 01 January 1987

Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells

scientific article published on 01 March 1985

Characterization of the insulin resistance of aging

scientific article published on June 1983

Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity

scientific article

Chemokine IP-10 expression in cultured human keratinocytes

scientific article

Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain

scientific article published on April 2004

Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men.

scientific article published in May 1998

Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization

scientific article published on 01 October 1985

Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3

scientific article

Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance ⬇️

scientific article published on September 28, 2010

Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells

scientific article published on 8 February 2006

Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach

scientific article published in May 2017

Coordinate regulation of glucose transporter function, number, and gene expression by insulin and sulfonylureas in L6 rat skeletal muscle cells

scientific article

Creating a Nobel culture

scientific article published in January 2013

Credit and Priority in Scientific Discovery: A Scientist's Perspective

scientific article published on 01 January 2019

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

scholarly article

Cytogenetic studies of a male with sporadic intestinal lymphangiectasia: 45,X/46,XY mosaicism with pseudo- and hyperdiploid subpopulations in cultured tissues

scientific article published on 01 January 1979

Dealing with Consequences of Irreproducibility and Modifying the Published Literature: Retractions versus Revisions

scientific article published in November 2017

Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.

scientific article

Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance

scientific article published on 01 December 1984

Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet.

scientific article published on 8 March 2018

Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance).

scientific article

Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms

scientific article published on 01 June 1991

Developing Core Competencies for the Prevention and Management of Prescription Drug Misuse: A Medical Education Collaboration in Massachusetts

scientific article

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

scientific article

Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation

scientific article

Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice

scientific article published on 01 October 2000

Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats

scientific article

Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment

scientific article

Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes

scientific article

Direct demonstration that receptor crosslinking or aggregation is important in insulin action ⬇️

scientific article published on September 1, 1978

Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor ⬇️

scientific article published on November 1, 1976

Diseases caused by antibodies to receptors

scientific article published on January 1, 1981

Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia.

scientific article published in November 1999

Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary.

scientific article published in October 1985

Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.

scientific article

Distributions of leptin receptor mRNA isoforms in the rat brain

scientific article

Divergent roles of SHP-2 in ERK activation by leptin receptors

scientific article published on 20 November 2000

Divergent signaling capacities of the long and short isoforms of the leptin receptor

scientific journal article

Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice

scientific article

Editorial: leptin as a therapeutic agent--trials and tribulations

scientific article published on 01 November 2000

Effect of Birth Weight and Maternal Smoking on Cord Blood Leptin Concentrations of Full-Term and Preterm Newborns1 ⬇️

scientific article published on September 1, 1997

Effect of Diet Upon the Erythrocyte Na,K Pump* ⬇️

scientific article published on April 1, 1983

Effect of sucrose overfeeding on Na,K-ATPase-mediated 86Rb uptake in normal and ob/ob mice

scientific article

Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity

scientific article published in May 2002

Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep

scientific article

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

scientific article published in March 1987

Endocrine function of neuropeptide Y knockout mice ⬇️

scientific article published on June 18, 1997

Endogenous digitalis-like activity in the plasma of the toad Bufo marinus ⬇️

scientific article published on May 24, 1979

Energetic pursuit of leptin function

scientific article published on 01 January 1997

Energy homeostasis and body weight

scientific article

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

scientific article

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

scientific article

Erythrocyte Na,K pump in uremia. Acute correction of a transport defect by hemodialysis ⬇️

scientific article published on August 1, 1984

Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.

scientific article published on July 1990

Evidence for constitutive neural cell proliferation in the adult murine hypothalamus.

scientific article

Evidence for coordinate genetic control of Na,K pump density in erythrocytes and lymphocytes

scientific article published on 01 August 1985

Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity

scientific article

Evidence that metformin increases insulin-stimulated glucose transport by potentiating insulin-induced translocation of glucose transporters from an intracellular pool to the cell surface in rat adipocytes

scientific article published on January 1992

Evidence that receptor aggregation may play a role in transmembrane signaling through the insulin-like growth factor-I receptor

scientific article published on 01 September 1988

Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine

scientific article

Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus

scientific article published on 01 February 1996

Expression of leptin receptor isoforms in rat brain microvessels

scientific article published in August 1998

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity ⬇️

scientific article published on September 1, 1995

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

scientific article published on February 2012

Faculty promotion must assess reproducibility

scientific article published in September 2017

Familial insulin resistance with acanthosis nigricans, acral hypertrophy, and muscle cramps.

scientific article

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

scientific article (publication date: 2016)

Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury

scientific article published on 19 August 2017

Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo

scientific article published on 24 February 2014

Fibroblast growth factor 21 has no direct role in regulating fertility in female mice

scientific article published on 18 May 2016

Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets

scientific article

Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis

scientific article

Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor

scientific article

Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.

scientific article

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation

article

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

scientific article published on October 1991

Functionally Abnormal Na+-K+ Pump in Erythrocytes of a Morbidly Obese Patient ⬇️

scientific article published on January 1, 1982

Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids

scientific article

Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).

scientific article published on June 1995

Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene

scientific article (publication date: 7 July 1999)

Gut check: testing a role for the intestinal microbiome in human obesity

scientific article published on 01 November 2009

Health care reform: without a correct diagnosis, there is no cure

scientific article

Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM.

scientific article published in July 1975

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

scientific article (publication date: June 2007)

Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes.

scientific article published in March 1981

High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats

scientific article published on August 1991

Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.

scientific article published on 25 September 2012

Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)

scientific article

Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue

scientific article

Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.

scientific article

Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha

scientific article published in April 2002

IP-10 mRNA expression in cultured keratinocytes is suppressed by inhibition of protein kinase-C and tyrosine kinase and elevation of cAMP

scientific article published on 01 July 1999

Identification of SOCS-3 as a potential mediator of central leptin resistance

scientific article

Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue

scientific article

Immunoprecipitation of the Insulin Receptor: A Sensitive Assay for Receptor Antibodies and a Specific Technique for Receptor Purification* ⬇️

scientific article published on January 1, 1979

Immunosuppression by alpha blockade

scientific article published on 01 May 1971

Impaired in vivo insulin clearance in patients with severe target-cell resistance to insulin

scientific article published on 01 February 1982

In Reply to Manion and Khan

scientific article published in June 2017

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

scientific article published on July 2000

Insulin Receptors and Insulin Resistance ⬇️

scientific article published on January 1, 1983

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

scientific article published on January 1, 1981

Insulin administered intranasally as an insulin-bile salt aerosol. Effectiveness and reproducibility in normal and diabetic subjects.

scientific article published in November 1983

Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population

scientific article published on May 1, 1992

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

scientific article

Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.

scientific article published in June 2003

Insulin resistance--mechanisms, syndromes, and implications

scientific article published on September 1991

Insulin resistance: the clinical spectrum

scientific article published on January 1, 1995

Insulin stimulation of aminoisobutyric acid transport in human skin fibroblasts is mediated through both insulin and type I insulin-like growth factor receptors

scientific article published on 01 November 1986

Insulin-Resistant Diabetes with Insulin Receptor Autoantibodies in a Male Patient Without Acanghosis Nigricans ⬇️

scientific article published on May 1, 1979

Insulin-like growth factor I (rhIGF-I) as a therapeutic agent for hyperinsulinemic insulin-resistant diabetes mellitus.

scientific article published in August 1995

Insulin-mediated hypokalemia and paralysis in familial hypokalemic periodic paralysis.

scientific article

Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.

scientific article published in June 1993

Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo

scientific article

Irreproducibility of published bioscience research: Diagnosis, pathogenesis and therapy

scientific article

Lasker Lauds Leptin ⬇️

scientific article published on 01 October 2010

Lasker lauds leptin

scientific article

Leptin

scientific article

Leptin Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Response to Stress1 ⬇️

scientific article published on September 1, 1997

Leptin accelerates the onset of puberty in normal female mice

scientific article published on February 1997

Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.

scientific article published on January 1998

Leptin activates neurons in ventrobasal hypothalamus and brainstem

scientific article published on 01 February 1997

Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans

scientific article published on 01 October 1997

Leptin concentrations in the polycystic ovary syndrome

scientific article published on June 1997

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

scientific article

Leptin expression and action: new experimental paradigms

scientific article

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

scientific article

Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus

scientific article published in June 1997

Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways

scientific article published on 01 November 2000

Leptin regulation of neuroendocrine systems

scientific article

Leptin regulation of the mesoaccumbens dopamine pathway.

scientific article published on September 2006

Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes?

scientific article

Leptin, nutrition, and reproduction: timing is everything

scientific article published on 01 February 2000

Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring

scientific article published on April 2000

Ligand-binding properties of the two isoforms of the human insulin receptor

scientific article

Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin

scientific article published on 01 August 1997

Lilly Lecture: syndromes of insulin resistance. From patient to gene and back again

scientific article published on September 1, 1992

Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis

scientific article published on 14 November 2019

Loss of insulin binding and insulin receptor mRNA in a transformed human fetal fibroblast cell line

scientific article published on June 1990

Lowered leptin slims immune response

scientific article published on 01 October 1998

Lymphocyte stimulation by allogeneic and autochthonous cultured lymphoid cells ⬇️

scientific article published on 01 December 1970

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype

scientific article published on August 2003

Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

scientific article

Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.

scientific article published in April 1998

Metabolic importance of acanthosis nigricans.

scientific article

Mice lacking melanin-concentrating hormone are hypophagic and lean

scientific article

Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis?

scientific article published on 23 March 2020

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

scholarly article

Molecular cloning of two small GTP-binding proteins from human skeletal muscle

scientific journal article

Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects

scientific article

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts

scientific article

Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia

scientific article

Multiple factors influence insulin-like growth factor-I binding to human skin fibroblasts

scientific article published on 01 August 1989

Muscle-Specific Expression of Human Insulin Receptor in Transgenic Mice

scientific article published on 01 January 1993

Nasal absorption of insulin: enhancement by hydrophobic bile salts

scientific article

Neurogenesis in the hypothalamus of adult mice: potential role in energy balance

scientific article

Neuroscience. Regulating energy balance: the substrate strikes back

scientific article

Neuroscience. The fat-brain axis enters a new dimension

scientific article published in April 2004

Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM

scientific article published on 01 November 1989

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

scientific article published on April 2004

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State ⬇️

scientific article published on August 3, 2010

Obesity after genetic ablation of brown adipose tissue

scientific article published on January 1998

Obesity and insulin resistance

scientific article

Obesity and the hypothalamus: novel peptides for new pathways

scientific article

Obesity and the regulation of energy balance

scientific article published on 23 February 2001

Obesity research springs a proton leak

scientific article published on 01 March 1997

Obesity wars: molecular progress confronts an expanding epidemic

scientific article (publication date: 23 January 2004)

Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport ⬇️

scientific article published on July 20, 1978

Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin

scientific article

Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance

scientific article published in March 2006

Overproduction of the beta 1 form of protein kinase C enhances phorbol ester induction of glucose transporter mRNA.

scientific article

PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

scientific article

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids

scientific article published on May 1997

Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy.

scientific article published in September 1989

Physiology: is brain sympathetic to bone?

scientific article published in December 2002

Platelet-derived growth factor regulates glucose transporter expression

scientific article published on 01 November 1988

Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism ⬇️

scientific article

Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function

scientific article published on March 1998

Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.

scientific article published in February 1994

Principles of receptor identification

scientific article published on January 1, 1981

Problems of insulin resistance.

scientific article published in October 1988

Pushing the envelope on lipodystrophy.

scientific article

Questions and answers on diabetes. A panel discussion

Radioimmunoassay of the Insulin Receptor: A New Probe of Receptor Structure and Function ⬇️

scientific article published on February 9, 1979

Receptors for peptide hormones. New insights into the pathophysiology of disease states in man.

scientific article published on February 1977

Receptors, Antireceptor Antibodies and Mechanisms of Insulin Resistance ⬇️

scientific article published on February 22, 1979

Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance.

scientific article published in July 1994

Reduced activity of the red-cell sodium-potassium pump in human obesity

scientific article published on 01 October 1980

Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.

scientific article published on 09 April 2009

Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine

scientific article

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

scientific article

Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes.

scientific article published on 9 June 2004

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

scientific article published on June 1996

Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number

scientific article

Regulation of glucose-transporter gene expression in vitro and in vivo

scientific article published on June 1990

Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization

scientific article published in April 2003

Regulation of neuronal and glial proteins by leptin: implications for brain development

scientific article

Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.

scientific article published on July 1992

Relationship between c-src tyrosine kinase activity and the control of glucose transporter gene expression

scientific article published on 01 November 1989

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice

scientific article published on 27 December 2011

Role of leptin in the neuroendocrine response to fasting

scientific article (publication date: 18 July 1996)

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

scientific article (publication date: 22 December 2000)

Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight

scientific article published on 31 July 2008

Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations

scientific article

Severely impaired adipsin expression in genetic and acquired obesity

scientific article

Sex differences in circulating human leptin pulse amplitude: clinical implications

scientific article

Short-term hyperthyroidism has no effect on leptin levels in man

scientific article published on 01 February 1997

Specific insulin binding sites in human ovary

scientific article

Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin

article

Status of the red cell Na,K-pump in hyper- and hypothyroidism ⬇️

scientific article published on 01 January 1983

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling

scientific article published on 4 June 2004

Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans

scientific article

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women.

scientific article

TLR4 links innate immunity and fatty acid-induced insulin resistance

scientific article (publication date: November 2006)

Targeted disruption of the beta 3-adrenergic receptor gene.

scientific article published in December 1995

The CXCR3 activating chemokines IP-10, Mig, and IP-9 are expressed in allergic but not in irritant patch test reactions

scientific article published on 01 October 1999

The Evolving Clinical Course of Patients with Insulin Receptor Autoantibodies: Spontaneous Remission or Receptor Proliferation with Hypoglycemia ⬇️

scientific article published on November 1, 1978

The Stimulation of pp42mapkinase by Insulin Does Not Correlate with Its Metabolic Actions in Cells Overexpressing Mutant Insulin Receptors

scientific article published on 01 October 1993

The US Health Provider Workforce: Determinants and Potential Paths to Enhancement

scientific article published on 01 January 2020

The Underlying Insulin Receptor in Patients with Antireceptor Autoantibodies: Demonstration of Normal Binding and Immunological Properties ⬇️

scientific article published on July 1, 1979

The adipocyte as an active participant in energy balance and metabolism

scientific article published on May 2007

The adipocyte: storage depot or node on the energy information superhighway?

scientific article

The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes

scientific article published on 27 October 2005

The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells

scientific article (publication date: June 2001)

The diagnosis of diabetes: who is a diabetic and why?

The gut and energy balance: visceral allies in the obesity wars

scientific article

The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts

scientific article (publication date: 10 October 1997)

The immunology of the insulin receptor

scientific article published on January 1976

The missing link with obesity?

scientific article published in Nature

The organization, promoter analysis, and expression of the human PPARgamma gene

scientific article (publication date: 25 July 1997)

The potential significance of beta 3 adrenergic receptors

scientific article published on March 1995

The role of SOCS-3 in leptin signaling and leptin resistance

scientific journal article

The stomach speaks--ghrelin and weight regulation

scientific article published in May 2002

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

scientific article

Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner

scientific article

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

scientific article

Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome

scientific article published on December 2003

Tissue-specific nutritional regulation of angiotensinogen in adipose tissue

scientific article published on April 1, 1992

Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells

scientific article

Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

scientific article

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

scientific article

Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia.

scientific article published in June 1996

Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice.

scientific article

Treatment by plasma exchange of a patient with autoantibodies to the insulin receptor

scientific article published on March 1, 1979

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

scientific article

U-500 insulin in the treatment of antibody-mediated insulin resistance.

scientific article

UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue

scientific article

Unraveling the central nervous system pathways underlying responses to leptin

scientific article

Vanadate regulates glucose transporter (Glut-1) expression in NIH3T3 mouse fibroblasts

scientific article published on October 1990

What fuels fat

scientific article published on 01 September 2007

What’s in a Name? In Search of Leptin’s Physiologic Role1

scientific article published on 01 May 1998

Widespread Occurrence in Frogs and Toads of Skin Compounds Interacting with the Ouabain Site of Na + , K + -ATPase ⬇️

scientific article published on May 2, 1980

Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity

scientific article published on February 2007

α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.

scientific article published in January 2013

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