List of works by Frans G Russel

A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women.

scientific article published on 8 March 2018

A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption

scientific article published in 2022

ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney.

scientific article

AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

scientific article published on 23 August 2012

Absorption of High Dose Furosemide (Frusemide) in Congestive Heart Failure

scientific article published on April 1, 1992

Accumulation of salicylic acid and indomethacin in isolated proximal tubular cells of the rat kidney.

scientific article

Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis.

scientific article

Aggregate dermal exposure to cyclic siloxanes in personal care products: implications for risk assessment

scientific article

Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.

scientific article

Alternating Hemiplegia of Childhood mutations have a differential effect on Na(+),K(+)-ATPase activity and ouabain binding.

scientific article published on 12 March 2014

Anionic and cationic drug secretion in the isolated perfused rat kidney after neonatal surgical induction of ureteric obstruction.

scientific article published in September 2003

Antioxidants and pre-eclampsia

scientific article published in January 2000

Application of urine proteomics for biomarker discovery in drug-induced liver injury.

scientific article published on 29 September 2014

Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity

scientific article

Biochemical characterization of sporadic/familial hemiplegic migraine mutations.

scientific article published on 3 April 2014

Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: evaluation with computational analytical tools

scientific article

Biomarkers for methotrexate-induced liver injury: urinary protein profiling of psoriasis patients

scientific article

Blockade of vascular ATP-sensitive potassium channels reduces the vasodilator response to ischaemia in humans

scientific article published on 01 December 1996

Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.

scientific article

Bromide as a marker to measure adherence to drug therapy

scientific article published on 07 March 2006

Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4.

scientific article published on 21 April 2011

Cardiovascular effects of sulphonylurea derivatives.

scientific article published on July 1996

Cathepsin L is crucial for the development of early experimental diabetic nephropathy.

scientific article published on 26 August 2016

Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines

scientific article published on 4 October 2006

Combination diuretic therapy in severe congestive heart failure.

scientific article published on February 1998

Combination of methotrexate and sulphasalazine in patients with rheumatoid arthritis: pharmacokinetic analysis and relationship to clinical response

scientific article

Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule

scientific article published on 30 September 2020

Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

scientific article

Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo.

scientific article published in August 2005

Convallatoxin: a new P-glycoprotein substrate

scientific article published on 28 September 2014

Corrigendum to 'Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs' [European Journal of Pharmaceutical Sciences 115 (2018) 175-184]

article

Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation.

scientific article published on 10 April 2008

Deficiency of Either P-Glycoprotein or Breast Cancer Resistance Protein Protect against Acute Kidney Injury

scientific article published on 04 May 2010

Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression

scientific article

Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

scientific article published on 5 January 2018

Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis

scientific article published on 13 June 2019

Developmental patterns in human blood-brain barrier and blood-cerebrospinal fluid barrier ABC drug transporter expression

scientific article published on 24 May 2020

Differences in P-glycoprotein activity in human and rodent blood-brain barrier assessed by mechanistic modelling

scientific article published on 15 July 2021

Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels

scientific article published on 17 February 2012

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

scientific article published on 12 July 2018

Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1.

scientific article published on 17 December 2012

Dysfunction of the cyclo-oxygenase pathway in the foetoplacental circulation in Type 1 diabetes mellitus

scientific article published on 01 April 2005

Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon.

scientific article

Effect of drugs on renal development.

scientific article

Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4.

scientific article

Effect of substituted benzoylglycines (hippurates) and phenylacetylglycines on p-aminohippurate transport in dog renal membrane vesicles

scientific article published on 01 December 1994

Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells.

scientific article published on 21 December 2016

Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro.

scientific article published on 6 September 2013

Experimental study of diclofenac and its biliary metabolites on anastomotic healing

scientific article published on 17 May 2018

Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists.

scientific article

Exposure to total and protein-unbound rifampin is not affected by malnutrition in Indonesian tuberculosis patients.

scientific article published on 23 March 2015

Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.

scientific article published in July 2000

Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity.

scientific article published on 7 March 2018

Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions

scientific article

Feline hepatic biotransformation of diazepam: Differences between cats and dogs.

scientific article

First reported use of elvitegravir and cobicistat during pregnancy.

scientific article

Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations.

scientific article published on 17 July 2017

Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions.

scientific article

Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4).

scientific article

Gait analysis in a mouse model resembling Leigh disease.

scientific article published on 9 September 2015

Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism

scientific article published on August 2005

Glutathione status and the renal elimination of inorganic mercury in the Mrp2(-/-) mouse.

scientific article

HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis

scientific article published on 01 November 2008

Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.

scientific article published on 17 December 2015

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

scientific article published on 29 May 2020

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

scientific article published on 28 September 2004

Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice

scientific article

Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus.

scientific article published in March 2005

Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats.

scientific article

In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors.

scientific article published on 23 April 2014

In silico identification of potential cholestasis-inducing agents via modeling of Na(+)-dependent taurocholate cotransporting polypeptide substrate specificity

scientific article

In vivo release of rhBMP-2 loaded porous calcium phosphate cement pretreated with albumin

scientific article published on 01 October 2006

Including carrier-mediated transport in oral uptake prediction of nutrients and pharmaceuticals in humans

scientific article published on 22 October 2014

Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure

scientific journal article

Indometacin: renal handling and effects in the isolated perfused rat kidney

scientific article published on 01 January 1991

Inhibition of choline uptake in syncytial microvillus membrane vesicles of human term placenta. Specificity and nature of interaction

scientific article published on 01 November 1995

Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP.

scientific article published on 21 March 2016

Inhibitory potential of tuberculosis drugs on ATP-binding cassette drug transporters.

scientific article published on 9 October 2015

Insights into the role of bone marrow-derived stem cells in renal repair.

scientific article published on 20 March 2008

Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3.

scientific article published on 6 May 2014

Interaction of digitalis-like compounds with p-glycoprotein

scientific article

Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP).

scientific article published on 16 September 2011

Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4.

scientific article published on 12 September 2013

Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport

scientific article published on 27 September 2006

Interaction of sulphonylurea derivatives with vascular ATP-sensitive potassium channels in humans

scientific article published on 01 September 1996

Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules.

scientific article published on 19 May 2006

Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis

scientific article

Ion-pair solid-phase extraction of cimetidine from plasma and subsequent analysis by high-performance liquid chromatography

scientific article published on 01 November 1994

Iron chelation or anti-oxidants prevent renal cell damage in the rewarming phase after normoxic, but not hypoxic cold incubation

scientific article published on 27 February 2007

Iron chelators do not reduce cold-induced cell injury in the isolated perfused rat kidney model.

scientific article

Isolated perfused rat kidney as a tool in the investigation of renal handling and effects of nonsteroidal antiinflammatory drugs

scientific article published on 01 September 1990

Isolation of syncytial microvillous membrane vesicles from human term placenta and their application in drug-nutrient interaction studies.

scientific article published on September 1995

Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones.

scientific article

Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane

scientific article (publication date: 28 August 2009)

MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum

scientific article

Mass spectrometry analysis of hepcidin peptides in experimental mouse models

scientific article

Mechanisms of drug transfer across the human placenta

scientific article published on 01 August 1998

Mechanisms of renal anionic drug transport

scientific article published on 15 March 2008

Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model.

scientific article published on 6 September 2017

Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity

scientific article

Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux.

scientific article published on October 2015

Modeling mitochondrial dysfunctions in the brain: from mice to men.

scientific article published on 14 July 2011

Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport

scientific article published on 01 May 2003

Molecular aspects of renal anionic drug transport

scientific article

Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites

scientific article published on 29 August 2015

Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation

scientific article

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

scientific article published on 18 March 2008

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia

scientific article

Na+ and H+ gradient-dependent transport of p-aminohippurate in membrane vesicles from dog kidney cortex

scientific article published on 01 July 1988

Na+,K+-ATPase Isoform Selectivity for Digitalis-Like Compounds Is Determined by Two Amino Acids in the First Extracellular Loop

scientific article published on 12 November 2014

Na,K-ATPase activity modulates Src activation: A role for ATP/ADP ratio

scientific article published in May 2012

Naproxen and indomethacin: disposition and effects in the isolated perfused rat kidney

scientific article published on 01 September 1990

Nasal absorption of hydroxocobalamin in healthy elderly adults

scientific article published on January 1998

Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.

scientific article published on 12 February 2008

Nitric oxide-mediated vascular tone in the fetal placental circulation of patients with type 1 diabetes mellitus.

scientific article

P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury

scientific article published on 12 September 2007

Pancuronium masks the prejunctional muscarinic autoreceptor in guinea pig tracheal smooth muscle

scientific article published on 01 January 1995

Parenteral bilirubin in healthy volunteers: a reintroduction in translational research.

scientific article published on 25 October 2017

PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs

scientific article

Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity.

scientific article published on 21 April 2012

Physiologically Based Modelling of Darunavir/Ritonavir Pharmacokinetics During Pregnancy

scientific article published on 14 September 2015

Physiologically based pharmacokinetic model for the renal clearance of iodopyracet and the interaction with probenecid in the dog

scientific article published on 01 March 1989

Physiologically based pharmacokinetic model for the renal clearance of phenolsulfonphthalein and the interaction with probenecid and salicyluric acid in the dog

scientific article published on 01 August 1987

Placental disposition of eculizumab, C5 and C5-eculizumab in two pregnancies of a woman with paroxysmal nocturnal haemoglobinuria

scientific article published on 28 September 2020

Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue

scientific article published on 12 April 2018

Placental transfer of the HIV integrase inhibitor dolutegravir in an ex vivo human cotyledon perfusion model

scientific article published on 3 November 2015

Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia.

scientific article

Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling

scientific article

Presence and mechanism of direct vascular effects of amiloride in humans

scientific article published on 01 September 1999

Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study

scientific article published on 02 March 2011

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

scientific article published on 23 October 2017

Protective Efficacy Induced by Genetically Attenuated Mid-to-Late Liver-Stage Arresting Plasmodium berghei Δmrp2 Parasites

scientific article published on 13 June 2016

Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.

scientific article

Quantitative urine collection in renal clearance studies in the dog

scientific article published on 01 April 1987

Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule.

scientific article

Regulation and expression of endothelin-1 (ET-1) and ET-receptors in rat epithelial cells of renal and intestinal origin

scientific article published on 3 September 2006

Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha

scientific article published on 9 March 2010

Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules

scientific article

Renal clearance of sulphinpyrazone in man

scientific article published on 01 January 1986

Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus.

scientific article published on 10 January 2014

Review article: direct-acting antivirals for the treatment of HCV during pregnancy and lactation - implications for maternal dosing, foetal exposure, and safety for mother and child

scientific article published on 25 August 2019

Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system

scientific article published on 01 March 1997

Role of NO in endothelin-regulated drug transport in the renal proximal tubule

scientific article published in March 2002

Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial

scientific article published on 20 July 2015

Saturable accumulation and diuretic activity of hydrochlorothiazide in the isolated perfused rat kidney

scientific article published on 01 January 1997

Screening for the role of transporters in hepatic and renal drug handling

scientific article published on 01 December 2004

Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip

scientific article published on 26 July 2018

Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury

scientific article published on 29 September 2009

Sensitive method for quantification of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air by thermal desorption gas chromatography mass spectrometry.

scientific article published on 3 June 2014

Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule.

scientific article published in May 2002

Short-term beneficial effects of methylene blue on kidney damage in septic shock patients.

scientific article

Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity.

scientific article published on 5 August 2005

Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs)

scientific article published on 06 October 2015

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

scientific article published on September 2015

Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism.

scientific article published on 9 October 2017

Substantially lowered dolutegravir exposure in a treatment-experienced perinatally HIV-1-infected pregnant woman.

scientific article published on July 2016

Sulphonylurea drugs reduce hypoxic damage in the isolated perfused rat kidney.

scientific article published on August 2000

The ABCs of multidrug resistance in malaria

scientific article published on 11 June 2010

The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.

scientific article published on March 2002

The Role of Efflux Pumps in Tuberculosis Treatment and Their Promise as a Target in Drug Development: Unraveling the Black Box.

scientific article

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.

scientific article

The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers.

scientific article published on 15 March 2016

The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP

scientific article

The heme-heme oxygenase system in wound healing; implications for scar formation

scientific article published on December 2010

The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats

scientific article published on December 2008

The role of ATP binding cassette transporters in tissue defense and organ regeneration.

scientific article

Theophylline improves hypoglycemia unawareness in type 1 diabetes

scientific article published in March 2002

Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

scientific article published on 15 September 2017

Therapeutic implications of renal anionic drug transporters.

scientific article published on 20 March 2010

Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4

scientific article published on 12 March 2012

Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins

scientific article published in 2024

Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.

scientific article

Uptake of choline into syncytial microvillus membrane vesicles of human term placenta

scientific article published on 01 February 1994

Uremic Solutes in Chronic Kidney Disease and Their Role in Progression

scientific article

Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.

scientific article

Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice

scientific article published on 16 March 2013

Urine collection methods for non-toilet-trained children in biological monitoring studies: validation of a disposable diaper for characterization of tebuconazole exposure

article

Usage patterns of personal care products: important factors for exposure assessment

scientific article

Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients.

scientific article published in February 2002

Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development

scientific article published on 15 March 2016

Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique

scientific article published on 5 February 2010

cCMP is a substrate for MRP5

scientific article published on 15 July 2014

p-aminohippurate uptake by syncytial microvillous membrane vesicles of human term placenta.

scientific article

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