List of works by Elena Aikawa

18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis

scientific article published on October 2009

2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders

scientific article published on 29 October 2020

3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.

scientific article published on 13 March 2016

A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease.

scientific article

A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis.

scientific article

A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program

scientific article

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification

scientific article published on 09 June 2016

Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.

scientific article published on 11 February 2008

Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves

scientific article published on 01 November 2001

Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation.

scientific article published on 13 July 2009

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

scientific article published on 29 August 2016

After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology

An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease

scientific article published on 28 September 2020

Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis

scientific article published on 16 September 2020

Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis

scientific article published on 08 July 2020

ApoC-III is a novel inducer of calcification in human aortic valves

scientific article published on 17 December 2020

Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.

scientific article published on 23 March 2009

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation

scientific article

CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction.

scientific article published on 6 October 2016

CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction

scientific article published on 24 December 2020

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

scientific article

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

scientific article published in October 2011

Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.

scientific article published on 10 November 2017

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.

scientific article published on 31 May 2016

Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation

scientific article published on 10 March 2013

Cardiovascular calcification: an inflammatory disease

scientific article published on 12 May 2011

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery

scientific article published on 01 May 2019

Cardiovascular calcification: current controversies and novel concepts.

scientific article published on 10 March 2015

Cardiovascular inflammation

scientific article published on 19 March 2012

Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease

scientific article published in January 2017

Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials

scholarly article by Farouc A. Jaffer et al published April 2006 in Molecular imaging : official journal of the Society for Molecular Imaging

Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials

scientific article published on April 2006

Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging

scientific article published on 03 October 2005

Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells

scientific article published on 08 May 2006

Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages.

scientific article

Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.

scientific article published in October 2004

Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy

scientific article published on 25 December 2008

Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency

scientific article published on 5 September 2016

Complex association of lipoprotein(a) with aortic stenosis

scientific article published on 21 February 2020

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics <i>via</i> an injectable self-healing hydrogel

scientific article published on 16 December 2021

Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research

scientific article published on 14 July 2016

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.

scientific article published on 28 November 2011

Cystathionine γ-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis

scientific article published on 19 December 2013

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

scientific article published on 27 February 2018

Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.

scientific article

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma.

scientific article published in September 1999

Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis

scientific article published on 01 February 2019

Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium.

scientific article published on 19 March 2009

Dimerization of sortilin regulates its trafficking to extracellular vesicles

scientific article

Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform

scientific article

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.

scientific article published on 21 January 2016

Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system

scientific article published on 25 June 2020

Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.

scientific article published on 22 March 2007

Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.

scientific article published on 12 June 2017

EVpedia: a community web portal for extracellular vesicles research

scientific article

Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo

scholarly article

Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine

Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases

Editorial: Insight in heart valve disease: 2021

scientific article published in 2022

Effect of Losartan on Mitral Valve Changes After Myocardial Infarction

scientific article published in September 2017

Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets

scientific article published on 22 June 2021

Elastogenesis at the onset of human cardiac valve development

scientific article

Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation

scientific article published on 05 June 2017

Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves.

scientific article

Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review

scientific article published on 01 January 2019

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.

scientific article

Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol

scientific article

Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis.

scientific article

Extracellular Vesicles As Mediators of Cardiovascular Calcification

scientific article published on 11 December 2017

Extracellular vesicles in cardiovascular calcification: expanding current paradigms.

scientific article published on 29 January 2016

Extracellular vesicles in cardiovascular disease: focus on vascular calcification

scientific article published on 01 June 2016

Extracellular vesicles in cardiovascular homeostasis and disease.

scientific article published on 19 February 2018

F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata

scientific article

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion.

scientific article published on 20 April 2017

Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction.

scientific article published on 3 March 2018

Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo

scientific article published on 05 March 2007

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

scientific article

Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II

scientific article

Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field

scientific article published in January 2017

Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease

scientific article published on 17 December 2020

Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep.

scientific article published on 21 June 2007

Heart Valve Disease: Challenges and New Opportunities

scientific article published on 22 October 2020

Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus

scientific article published on 29 June 2016

Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy

scientific article published on 01 June 2001

Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.

scientific article

Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering

scientific article published in March 2006

Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.

scientific article published on 16 July 2009

Identification of splenic reservoir monocytes and their deployment to inflammatory sites

scientific article

Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.

scientific article

In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease

scientific article

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation

scientific article

In vivo monitoring of function of autologous engineered pulmonary valve

scientific article

Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques

scientific article

Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo

scientific article published on 26 June 2006

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment

scientific article published on 01 July 2005

Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis

scientific article published on 05 January 2012

Innate and adaptive immunity in cardiovascular calcification

scientific article published on 28 February 2020

Interferon-γ Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.

scientific article published on 18 April 2017

International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013).

scientific article

Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study

scientific article published in August 2010

Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis

scientific article published on 22 May 2013

Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.

scientific article published in June 1998

Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma

scientific article published on 01 November 1998

Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis

scientific article published on 28 January 2022

Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis

Look More Closely at the Valve

scientific article published on 16 November 2011

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

scientific article

Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.

scientific article published in June 2017

Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques

scientific article published on 24 April 2013

Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques

scientific article published on 17 October 2005

Medial and intimal calcification in chronic kidney disease: stressing the contributions.

scientific article published on 23 September 2013

MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk

scientific article published on 26 November 2019

MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.

scientific article published on March 2013

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling

scientific article published in November 2017

Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes

scientific article published on 11 September 2020

Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation.

scientific article published on 8 December 2017

Mitral Valve Adaptation: Can We Win the Race?

scientific article published on 01 April 2018

Mitral valve disease--morphology and mechanisms

scientific article

Mitral valve endothelial cells with osteogenic differentiation potential.

scientific article

Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation.

scientific article published on March 2014

Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.

scientific article published on September 2009

Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia

scientific article published on 29 September 2009

Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification

scientific article

Molecular imaging of innate immune cell function in transplant rejection

scientific article published on 30 March 2009

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease

scholarly article

Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.

scientific article published on 15 January 2007

Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis

scientific article

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.

scientific article published on January 2016

N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification

scientific article published on 15 April 2015

Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.

scientific article published on 24 December 2007

New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study

scientific article

Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis

scientific article published on July 2016

Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis

scientific article published on 25 September 2006

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

scientific article

Notch signaling in cardiovascular disease and calcification.

scientific article

Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor

scientific article published on 09 April 2007

Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo

scientific article published on 26 November 2007

Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation

scientific article

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

scientific article (publication date: 31 October 2016)

Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.

scientific article

Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.

scientific article

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.

scientific article published on 14 September 2015

Potential drug targets for calcific aortic valve disease.

scientific article

Progenitor cells confer plasticity to cardiac valve endothelium.

scientific article published on 26 July 2011

Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development

scientific article

Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis

scientific article published on 13 October 2008

Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects

scientific article published on 19 December 2019

Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries

scientific article published on 03 June 2013

Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach

scientific article published on 07 September 2015

Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification

scientific article published on 13 June 2013

Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism

S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus

scientific article published on 28 May 2020

Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease

scientific article

Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis

scientific article

Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.

scientific article published in February 2002

Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men.

scientific article published on 9 March 2017

Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves

scientific article

Simplified syntheses of complex multifunctional nanomaterials

scientific article published on 13 August 2008

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.

scientific article published on 17 March 2016

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability

scientific article

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.

scientific article published on 30 November 2017

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

scientific article

Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.

scientific article published on 27 March 2018

Standardization of Human Calcific Aortic Valve Disease Modeling Reveals Passage-Dependent Calcification

Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion

scientific article

Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development

scientific article published on 06 April 2021

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

scientific article published on July 2000

The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development

scientific article published on 30 July 2018

The antiproliferative cytostatic effects of a self-activating viridin prodrug

scientific article

The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells.

scientific article published on 18 October 2011

The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells

scientific article published on 26 November 2009

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase

scholarly article

Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.

scientific article

Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.

scientific article

Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries

scientific article

Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling

scientific article published on 01 January 2019

Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms

scientific article published on 11 July 2019

Valvular interstitial cells suppress calcification of valvular endothelial cells

scientific article

Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.

scientific article

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

scientific article

Visualizing novel concepts of cardiovascular calcification

scientific article published on 3 January 2013

Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition

scientific article published on 29 March 2022

Zooming in on the genesis of atherosclerotic plaque microcalcifications

scientific article published on 4 April 2016

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