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List of works by Jean-Christophe Marine

A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein

scientific article published in April 2007

A non-coding function of TYRP1 mRNA promotes melanoma growth.

scientific article

A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm

scientific article published in May 1997

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

scientific article published on 02 June 2022

Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma

scientific article published in 2021

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

scientific article published on 22 September 2017

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

scientific article published on July 2004

An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity

scientific article published on 16 November 2010

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours.

scientific article published on 12 April 2010

Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation

scientific article

Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth

scientific article

Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

scientific article

Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility

scientific article published on 16 October 2015

Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4.

scientific article

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

scientific article published on 16 May 2010

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.

scientific article

Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci

scientific article published on 01 June 1996

Codon-specific translation reprogramming promotes resistance to targeted therapy

scientific article published in Nature

Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma

scientific article published on 2 May 2017

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.

scientific article

Critical role for a central part of Mdm2 in the ubiquitylation of p53.

scientific article

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation ⬇️

scientific article

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

scientific article

Different levels of Twist1 regulate skin tumor initiation, stemness, and progression

scientific article published on 01 January 2015

Differential roles of cytokine signaling during T-cell development.

scientific article

Direct regulation of the Nrarp gene promoter by the Notch signaling pathway

scientific article

Distinct roles of Mdm2 and Mdm4 in red cell production

scientific article

Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma

scientific article published on 30 September 2016

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

scientific article published on 11 March 2009

Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals

scientific article published on 01 November 2021

Enhanced expression in seminoma of human zinc finger genes located on chromosome 19 ⬇️

scientific article published on January 1, 1998

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evi1 is specifically expressed in the distal tubule and duct of the Xenopus pronephros and plays a role in its formation

scientific article published on 30 March 2006

Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development

scientific article

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice

scientific journal article

Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3.

scientific article published on April 2011

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

scientific journal article

GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity

scientific article published on October 2004

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

scientific article

IGF2: the Achilles' heel of p53-deficiency?

scientific article

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

scientific article

Identification of the tumour transition states occurring during EMT.

scientific article published on 18 April 2018

Inactivation of the p53 pathway in retinoblastoma.

scientific article

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1

scientific article published on 03 July 2020

Interrogating open issues in cancer medicine with patient-derived xenografts

scientific article published on 15 September 2017

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Jak2 is essential for signaling through a variety of cytokine receptors

scientific article

Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development

scientific article published on January 2001

Journal club

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

scientific article

Localization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2.

scientific article published on 01 November 1992

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice.

scientific article published on 11 March 2014

Loss of oocytes due to conditional ablation of Murine double minute 2 (Mdm2) gene is p53-dependent and results in female sterility

scientific article

MDM2 and MDMX in Cancer and Development

scientific article published on January 1, 2011

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

scientific article

MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation

scientific article published on 31 January 2014

MDM4 is a key therapeutic target in cutaneous melanoma

scientific article published on 22 July 2012

MDM4 is a rational target for treating breast cancers with mutant p53.

scientific article published on 18 January 2017

MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond

scientific article published in July 2016

MDMX: from bench to bedside

scientific article published on February 2007

Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation.

scientific article

Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death

scientific article published on 26 May 2006

Mdm2-mediated ubiquitylation: p53 and beyond.

scientific article published on January 2010

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

scientific article

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

scholarly article

Mdmx and Mdm2: brothers in arms?

scientific journal article

Mdmx as an essential regulator of p53 activity

scientific article

Melanoma addiction to the long non-coding RNA SAMMSON.

scientific article published in March 2016

Melanoma models for the next generation of therapies

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

scientific article published in February 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

scientific article published on 18 December 2009

NEAT1-containing paraspeckles: Central hubs in stress response and tumor formation

scientific article published on 4 October 2016

Non-coding RNAs: the dark side of nuclear-mitochondrial communication

scientific article published on 17 March 2017

Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients

scientific article published on 06 October 2015

Nucleophosmin is required for DNA integrity and p19Arf protein stability

scientific journal article

Nucleophosmin regulates the stability and transcriptional activity of p53

scientific article

PTPRV is a key mediator of p53-induced cell cycle exit

scientific article published on 26 December 2005

Pharmacological Rescue of p53 in Cancer Therapy: Widening the Sensitive Tumor Spectrum by Targeting MDMX ⬇️

scientific article published on November 16, 2010

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

scientific article published on 01 July 2000

Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer

scientific article published on 23 November 2021

Reciprocal repression between P53 and TCTP

scientific article

Regulation of Melanoma Progression through the TCF4/miR-125b/NEDD9 Cascade

scientific article published on 9 March 2016

Regulation of SIRT6 protein levels by nutrient availability

scientific article published on 31 January 2008

SCENIC: single-cell regulatory network inference and clustering.

scientific article published on 9 October 2017

Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.

scientific article published on 10 January 2013

Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma

scientific article published on October 2006

Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion.

scientific article published on 18 June 2015

Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug/JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas

scientific article published on 21 May 2015

Spotlight on the role of COP1 in tumorigenesis ⬇️

scientific article published on 07 June 2012

Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency ⬇️

scientific article published on November 14, 2011

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.

scientific article published on 27 June 2018

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation

scientific article published on 5 August 2012

TPT1/ TCTP-regulated pathways in phenotypic reprogramming

scientific article published on 30 October 2012

Targeting Mdmx to treat breast cancers with wild-type p53.

scientific article

Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy

scientific article published on 10 September 2015

The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury.

scientific article

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

scientific article

The Xenopus doublesex-related gene Dmrt5 is required for olfactory placode neurogenesis

scientific article published on 9 October 2012

The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals

scientific journal article

The emerging role of long non-coding RNAs in cutaneous melanoma

scientific article published on 8 September 2016

The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice.

scientific article

The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth

scientific article published on 24 September 2019

The long noncoding RNA Neat1 is required for mammary gland development and lactation.

scientific article published on 14 October 2014

The ornithine decarboxylase gene is essential for cell survival during early murine development

scientific article

Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair

scientific article published on 27 July 2009

Translation rewiring at the heart of phenotype switching in melanoma

scientific article

Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value

scientific article published on 11 November 2021

Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo

scientific article published on 20 September 2010

c-Abl phosphorylates Hdmx and regulates its interaction with p53.

scientific article

dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53.

scientific article

iRegulon: from a gene list to a gene regulatory network using large motif and track collections

scientific article

p53 Reactivation by PRIMA-1(Met) (APR-246) sensitises (V600E/K)BRAF melanoma to vemurafenib.

scientific article published on 17 January 2016

p53 attenuates AKT signaling by modulating membrane phospholipid composition

scientific article

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

scientific article published on 4 July 2016

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway.

scientific article published on March 2013

p53 stabilization: the importance of nuclear import

scientific article published on 01 February 2010

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