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List of works by Jean-Charles Schwartz

4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists

scientific article published on May 2004

Acidic elements in histamine H(3) receptor antagonists

scientific article published on 21 January 2010

An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients

scientific article

Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.

scientific article

Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway

scientific article published on January 2004

Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin

scientific journal article

Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin

scientific article published on 15 September 2010

Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum

scientific article published in January 2003

Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat

scientific article (publication date: 15 August 2002)

Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms

scientific article

Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists

scientific article published on 2 June 2013

Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as potent and selective dopamine D3 receptor ligands

scientific article

Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening

scientific article

Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: dose-dependent effects in the human photosensitivity model

scientific article published on 8 May 2013

Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists

scientific article published on 8 February 2006

First metal-containing histamine H3 receptor ligands

scientific article published in June 2010

Homology Model Versus X-ray Structure in Receptor-based Drug Design: A Retrospective Analysis with the Dopamine D3 Receptor

scientific article

Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties

scientific article published in August 2002

Involvement of the direct striatonigral pathway in levodopa-induced sensitization in 6-hydroxydopamine-lesioned rats

scientific article

Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain

scientific article

N-(4-(4-(2-Halogenophenyl)piperazin-1-yl)butyl) substituted cinnamoyl amide derivatives as dopamine D2 and D3 receptor ligands

scientific article published on April 2007

N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands

scientific article published in August 2003

Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions

scientific article

Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds

scientific article published in April 2003

Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists

scientific article

Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial

scientific article published on 7 October 2013

Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists

scientific article published in May 2002

Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice

scientific article published in June 2002

Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial

scientific article published on 24 January 2017

Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives

scientific article published in October 2004

Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists

scientific article published in May 2004

Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists

scientific article published on 19 September 2016

The dopamine D3 receptor mediates locomotor hyperactivity induced by NMDA receptor blockade

scientific article published on August 2003

The histamine H3 receptor: from discovery to clinical trials with pitolisant

scientific article

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