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List of works by Richard W Farndale

A fluorescent approach for identifying P2X1 ligands

scientific article published on 28 May 2015

A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream.

scientific article

A simple bioconjugate attachment protocol for use in single molecule force spectroscopy experiments based on mixed self-assembled monolayers.

scientific article

A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides

scientific article

An Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in Collagens ⬇️

scientific article published on July 29, 2013

Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro.

scientific article

Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions.

scientific article published on April 2008

Cellular response to collagen-elastin composite materials

scientific article published on 23 December 2018

Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen

scientific article

Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity

scientific article published on 24 February 2020

Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1 ⬇️

scientific article published on October 28, 2010

Collagen-binding proteins: insights from the Collagen Toolkits

scientific article published on 13 September 2019

Collagen-induced platelet activation

scientific article

Collagen-platelet interactions: recognition and signalling

scientific article published on January 2003

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

scientific article

Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood

scientific article

Corrigendum to 'Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro' [Biochem. Pharmacol. 148 (2018) 288-297]

scientific article published on 01 November 2018

Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF

Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI

scientific article

Crystallographic insight into collagen recognition by discoidin domain receptor 2

scientific article

Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2

scientific article

Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment

scientific article

Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions.

scientific article published on 24 May 2017

Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation

scientific article published in 2012

Dynamic analysis of platelet deposition to resolve platelet adhesion receptor activity in whole blood at arterial shear rate.

scientific article

Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry

scientific article

Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.

scientific article published on 18 February 2016

First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes

scientific article

Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix

scientific article published on 29 July 2015

Identification and structural analysis of type I collagen sites in complex with fibronectin fragments

scientific article

Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III.

scientific article published on 2 April 2009

Identification of platelet function defects by multi-parameter assessment of thrombus formation

scientific article

Impact of UV- and carbodiimide-based crosslinking on the integrin-binding properties of collagen-based materials

scientific article published on 02 October 2019

Implications for Collagen Binding from the Crystallographic Structure of Fibronectin 6FnI1-2FnII7FnI

scientific article

Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex ⬇️

scientific article published on March 21, 2012

Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens

scientific article published on 3 September 2004

Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens

scientific article published on 16 May 2008

Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen toolkits II and III.

scientific article

Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy

scientific article

NMR spectroscopy of native and in vitro tissues implicates polyADP ribose in biomineralization

scientific article published in May 2014

New insights into the DT40 B cell receptor cluster using a proteomic proximity labeling assay

scientific article

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

scientific article

Optimisation of UV irradiation as a binding site conserving method for crosslinking collagen-based scaffolds.

scientific article

Platelet adhesion to decorin but not collagen I correlates with the integrin 2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system ⬇️

scientific article published on December 1, 2011

Platelet integrin alpha2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display

scientific article published in December 2005

Platelets amplify inflammation in arthritis via collagen-dependent microparticle production

scientific article

Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation

scientific article published on 28 February 2011

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

scientific article

Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells: a novel system for antigen production and phage antibody isolation

scientific article published on 7 September 2006

Proline provides site-specific flexibility for in vivo collagen

scientific article published in Scientific Reports

Rapid Synthesis of a Register-specific Heterotrimeric Type I Collagen Helix Encompassing the Integrin α2β1 Binding Site

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor

scientific article published on 23 December 2015

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces

scientific article published on 07 June 2019

Signal Pathways That Transduce Growth Factor-Stimulated Mitogenesis in Bone Cells ⬇️

scientific article published on July 1, 1998

Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation

scientific article

Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.

scientific article published on 16 February 2017

Structural basis for collagen recognition by the immune receptor OSCAR.

scientific article published on 9 November 2015

Structural basis of sequence-specific collagen recognition by SPARC

scientific article

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

scientific article

Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling

scientific article published on 11 December 2019

Structure of the integrin alpha2beta1-binding collagen peptide

scientific article

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

scientific article

The effect of purity upon the triple-helical stability of collagenous peptides

scientific article

The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function

scientific article

The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix

scientific article

The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.

scientific article published on 7 April 2016

The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression

scientific article

The properties conferred upon triple-helical collagen-mimetic peptides by the presence of cysteine residues.

scientific article published on 23 April 2012

The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage

scientific article

The streptococcal collagen-binding protein CNE specifically interferes with alphaVbeta3-mediated cellular interactions with triple helical collagen

scientific article

The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen

scientific article

Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites

scientific article published on 29 May 2018

Unique charge-dependent constraint on collagen recognition by integrin α10β1.

scientific article

Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III.

scientific article published on 2 December 2005

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner.

scientific article

alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens

scientific article

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