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List of works by Tsuyoshi Yokoi

A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development

scientific article

A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk.

scientific article published on 2 August 2016

A new era in the study of individual differences in drug metabolism and pharmacokinetics.

scientific article published in January 2013

A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.

scientific article published in September 2005

A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury.

scientific article published on 4 November 2015

A novel duplication type of CYP2A6 gene in African-American population

scientific article published on 31 January 2007

A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism.

scientific article published on 28 August 2013

A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity

scientific article published on 13 March 2012

Acute kidney injury model established by systemic glutathione depletion in mice

scientific article published on 15 February 2019

Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells

scientific article published on 7 December 2015

Allosteric kinetics of human carboxylesterase 1: species differences and interindividual variability.

scientific article published in December 2008

Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.

scientific article

An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells.

scientific article

An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver

scientific article

Application of chimeric mice with humanized liver for predictive ADME.

scientific article published on January 2007

Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24.

scientific article

Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen.

scientific article published on 11 June 2010

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice

scientific article published on 01 July 2007

Binding of steroidogenic factor-1 to the regulatory region might not be critical for transcriptional regulation of the human CYP1B1 gene.

scientific article published on March 2006

CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.

scientific article

CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline.

scientific article

CYP2A6 AND CYP2B6 are involved in nornicotine formation from nicotine in humans: interindividual differences in these contributions.

scientific article published on 31 August 2005

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele

scientific article published on 25 April 2006

CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.

scientific article

CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening Assay ⬇️

scientific article published on February 14, 2011

Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats

scientific article published on 13 April 2015

Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury

scientific article

Change of drug excretory pathway by CCl4-induced liver dysfunction in rat

scientific journal article

Changes in the expression of miRNAs at the pericentral and periportal regions of the rat liver in response to hepatocellular injury: comparison with the changes in the expression of plasma miRNAs.

scientific article

Characterization of novel CYP2A6 polymorphic alleles (CYP2A6*18 and CYP2A6*19) that affect enzymatic activity.

scientific article published on 17 May 2005

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury.

scientific article

Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects

scientific article published on 29 May 2013

Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice

scientific article published on 20 September 2018

Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: implication as early phase biomarkers for SOS

scientific article published on 17 July 2018

Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

scientific article published in September 2006

Contributions of arylacetamide deacetylase and carboxylesterase 2 to flutamide hydrolysis in human liver

scientific article published on 23 March 2012

Current Topics in Drug Metabolism and Drug Toxicity ⬇️

scientific article published on 01 January 2011

Cytochrome P450-mediated metabolism of estrogens and its regulation in human.

scientific article

Decreased responsiveness of naturally occurring mutants of human estrogen receptor alpha to estrogens and antiestrogens.

scientific article published on 18 May 2006

Development of a cell-based assay system considering drug metabolism and immune- and inflammatory-related factors for the risk assessment of drug-induced liver injury

scientific article published on 15 April 2014

Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.

scientific article published on 4 February 2014

Different inhibitory effects in rat and human carboxylesterases.

scientific article published on 18 February 2009

Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.

scientific article published on 27 May 2009

Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms.

scientific article published on 9 February 2007

Effects of silver nanoparticles on rat hepatic cytochrome P450 enzyme activity

scientific article published on 30 March 2012

Effects ofPhyllanthus amaruson the pharmacokinetics of midazolam and cytochrome P450 activities in rats ⬇️

scientific article published on February 20, 2012

Epigenetic regulation is a crucial factor in the repression of UGT1A1 expression in the human kidney.

scientific article published on 11 February 2013

Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.

scientific article

Essentials for starting a pediatric clinical study (1): Pharmacokinetics in children.

scientific article published on January 2009

Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.

scientific article

Establishment of MDCKII cell monolayer with metabolic activity by CYP3A4 transduced with recombinant adenovirus.

scientific article published on 14 August 2012

Establishment of a drug-induced rhabdomyolysis mouse model by co-administration of ciprofloxacin and atorvastatin.

scientific article published on 18 April 2018

Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism

scientific article published on 20 April 2015

Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis.

scientific article published on 6 March 2017

Establishment of a mouse model of troglitazone-induced liver injury and analysis of its hepatotoxic mechanism

scientific article published on 11 July 2019

Establishment of a novel mouse model for pioglitazone-induced skeletal muscle injury.

scientific article

Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity.

scientific article

Estradiol and progesterone modulate halothane-induced liver injury in mice ⬇️

scientific article published on April 8, 2011

Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs

scientific article published on 8 October 2013

Evaluation of expression and glycosylation status of UGT1A10 in Supersomes and intestinal epithelial cells with a novel specific UGT1A10 monoclonal antibody

scientific article published on 11 July 2017

Evaluation of human CYP1A2 and CYP3A4 mRNA expression in hepatocytes from chimeric mice with humanized liver.

scientific article published in December 2006

Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver.

scientific article

Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.

scientific article

Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD.

scientific article published on 25 March 2009

Expression of human cytochromes P450 in chimeric mice with humanized liver.

scientific article published on 21 September 2004

Fluoroquinolones and propionic acid derivatives induce inflammatory responses in vitro.

scientific article published on 11 March 2017

Genetic polymorphisms of CYP2A6 affect the in-vivo pharmacokinetics of pilocarpine.

scientific article published in September 2008

Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients

scientific article published on 01 June 2007

Glucuronidation of antiallergic drug, Tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite

scientific article published on 12 January 2007

Glucuronidation of thyroxine in human liver, jejunum, and kidney microsomes

scientific article published on 25 June 2007

Halothane-induced liver injury is mediated by interleukin-17 in mice.

scientific article

Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models.

scientific article

Human CYP2A6 is induced by estrogen via estrogen receptor.

scientific article

Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2.

scientific article published on 29 September 2010

Human CYP2E1 is regulated by miR-378.

scientific article published on 27 November 2009

Human UDP-Glucuronosyltransferase (UGT) 2B10 in Drug N-Glucuronidation: Substrate Screening and Comparison with UGT1A3 and UGT1A4 ⬇️

scientific article published on April 23, 2013

Human UDP-glucuronosyltransferase isoforms involved in haloperidol glucuronidation and quantitative estimation of their contribution

scientific article published on 25 October 2011

Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis

scientific article

Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine.

scientific article published on 12 August 2011

Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene.

scientific article published on 12 February 2008

Human paraoxonase 1 is the enzyme responsible for pilocarpine hydrolysis

scientific article published on 26 April 2011

Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver

scientific article

IL-4 mediates dicloxacillin-induced liver injury in mice.

scientific article published on 19 November 2010

Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats

scientific article published on 01 November 2018

Immunohistochemical analysis of CYP2A13 in various types of human lung cancers.

scientific article published on 22 February 2010

In Vitro Evaluation of Inhibitory Effects of Antidiabetic and Antihyperlipidemic Drugs on Human Carboxylesterase Activities ⬇️

scientific article published on September 1, 2010

In Vitro Investigation of the Glutathione Transferase M1 and T1 Null Genotypes as Risk Factors for Troglitazone-Induced Liver Injury ⬇️

scientific article published on April 21, 2011

In silico and in vitro approaches to elucidate the thermal stability of human UDP-glucuronosyltransferase (UGT) 1A9.

scientific article

In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver

scientific article published on 01 February 2007

In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver.

scientific article published in September 2005

In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver.

scientific article

Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers

scientific article published on 12 October 2006

Indiplon is hydrolyzed by arylacetamide deacetylase in human liver

scientific article published on 24 January 2014

Induction of human CYP1A2 and CYP3A4 in primary culture of hepatocytes from chimeric mice with humanized liver.

scientific article published in April 2005

Inhibition of cytochrome P450 2C9 expression and activity in vitro by allyl isothiocyanate.

scientific article published on August 2014

Inhibitory and inductive effects of Phikud Navakot extract on human cytochrome P450.

scientific article

Inhibitory effects of neurotransmitters and steroids on human CYP2A6.

scientific article published on 19 January 2007

Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes.

scientific article

Inhibitory effects of psychotropic drugs on mexiletine metabolism in human liver microsomes: prediction of in vivo drug interactions.

scientific article

Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes.

scientific article published on 18 February 2014

Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes.

scientific article

Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities.

scientific article

Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.

scientific article published on 8 June 2010

Interpretation of the effects of protein kinase C inhibitors on human UDP-glucuronosyltransferase 1A (UGT1A) proteins in cellulo.

scientific article published on 8 February 2011

Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury

scientific article published on 07 July 2011

Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice.

scientific article

Involvement of immune-related factors in diclofenac-induced acute liver injury in mice.

scientific article

Involvement of miRNAs in the early phase of halothane-induced liver injury.

scientific article published on 2 March 2014

Involvement of oxidative stress and immune- and inflammation-related factors in azathioprine-induced liver injury

scientific article published on 30 October 2013

Isoflavones inhibit nicotine C-oxidation catalyzed by human CYP2A6.

scientific article

Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

scientific article

Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat.

scientific article published on 30 July 2009

Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats

scientific article

Mechanism of Exacerbative Effect of Progesterone on Drug-Induced Liver Injury ⬇️

scientific article published on December 7, 2011

Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries ⬇️

scientific article published on July 24, 2012

Metabolic activation and inflammation reactions involved in carbamazepine-induced liver injury.

scientific article

Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.

scientific article published on 23 August 2012

MicroRNA regulates the expression of human cytochrome P450 1B1.

scientific article published on September 2006

MicroRNA-mediated Th2 bias in methimazole-induced acute liver injury in mice

scientific article published on 12 July 2016

MicroRNAs from biology to future pharmacotherapy: regulation of cytochrome P450s and nuclear receptors.

scientific article published on 30 April 2011

MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle.

scientific article published on 15 December 2009

Multiparametric assay using HepaRG cells for predicting drug-induced liver injury

scientific article published on 28 April 2015

N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.

scientific article published on 11 October 2013

N-Glycosylation plays a role in protein folding of human UGT1A9.

scientific article

Neutrophil depletion protects against zomepirac-induced acute kidney injury in mice.

scientific article published on 14 November 2017

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).

scientific article

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

scientific article published on 01 March 2008

P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

scientific article published on 11 April 2014

PPARα is regulated by miR-21 and miR-27b in human liver.

scientific article published on 12 May 2011

Pathogenetic analyses of carbamazepine-induced liver injury in F344 rats focused on immune- and inflammation-related factors

scientific article published on 29 September 2015

Plasma MicroRNA Profiles in Rat Models of Hepatocellular Injury, Cholestasis, and Steatosis ⬇️

scientific article published on February 17, 2012

Preparation of a specific monoclonal antibody against human UDP-glucuronosyltransferase (UGT) 1A9 and evaluation of UGT1A9 protein levels in human tissues.

scientific article published on 22 May 2012

Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation.

scientific article published on 25 March 2013

Product inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates.

scientific article published on 12 November 2007

Progesterone receptor membrane component 1 modulates human cytochrome p450 activities in an isoform-dependent manner

scientific article published on 08 August 2011

Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.

scientific article published on 13 May 2009

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

scientific article

Regulation of cytochrome b5 expression by miR-223 in human liver: effects on cytochrome P450 activities.

scientific article published on March 2014

Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats.

scientific article published on 23 June 2005

Retinoid X receptor α in human liver is regulated by miR-34a.

scientific article published on 14 May 2014

Role of cytochrome P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury.

scientific article published on 18 October 2014

Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries

scientific article published in January 2018

Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase

scientific article published on 21 April 2014

Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury

scientific article published on 18 August 2017

Simultaneous measurement of gene expression for hepatotoxicity in thioacetamide-administered rats by DNA microarrays.

scientific article

Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.

scientific article

Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.

scientific article published in June 2007

Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions.

scientific article published on 18 June 2007

Stimulation of Human Monocytic THP-1 Cells by Metabolic Activation of Hepatotoxic Drugs ⬇️

scientific article published on June 12, 2012

Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway.

scientific article published on 17 September 2010

Strain and interindividual differences in lamotrigine-induced liver injury in mice

scientific article published on 16 October 2018

Structure and Protein-Protein Interactions of Human UDP-Glucuronosyltransferases

scientific article

Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast

scientific article published on April 2015

Th2 cytokine‐mediated methimazole‐induced acute liver injury in mice ⬇️

scientific article published on March 9, 2012

Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes

scientific article published on 06 October 2010

Toxicological evaluation of acyl glucuronides utilizing half-lives, peptide adducts, and immunostimulation assays.

scientific article published on 31 October 2015

Toxicological implications of modulation of gene expression by microRNAs.

scientific article published on 29 June 2011

Toxicological potential of acyl glucuronides and its assessment.

scientific article published on 23 November 2016

Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice.

scientific article published on 27 September 2016

Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes.

scientific article published on 6 October 2004

Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2).

scientific article

Troglitazone.

scientific article published on January 2010

Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice

scientific article published on 25 April 2016

[Establishment of animal models of drug-induced liver injury and analysis of possible mechanisms]

scientific article published on 01 January 2015

[Evaluation of phase II drug metabolizing enzymes in the discovery stage]

scientific article published on 01 December 2009

[New prospectives and understanding in drug-induced liver injury considering drug metabolism and immune- and inflammation-related factors]

scientific article published on 01 July 2014

miRNA in Rat Liver Sinusoidal Endothelial Cells and Hepatocytes and Application to Circulating Biomarkers that Discern Pathogenesis of Liver Injuries.

scientific article published on 15 January 2018

microRNAs as Mediators of Drug Toxicity ⬇️

scientific article published on November 16, 2012

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