List of works - Aras Kadioglu

A Subtype of a Pseudomonas aeruginosa Cystic Fibrosis Epidemic Strain Exhibits Enhanced Virulence in a Murine Model of Acute Respiratory Infection

scientific article published on 01 September 2010

A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia

scholarly article by Katia De Filippo et al published August 2014 in FASEB Journal

Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections

scientific article published on 13 October 2011

Adhesion of rheumatoid peripheral blood and synovial fluid mononuclear cells to high endothelial venules of gut mucosa ⬇️

scientific article published on January 1, 1992

Airborne dust and high temperatures are risk factors for invasive bacterial disease.

scientific article published on 14 July 2016

Alternatives to antibiotics—a pipeline portfolio review

scientific article (publication date: February 2016)

Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis.

scientific article published on 2 August 2016

Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse Pseudomonas aeruginosa from Cystic Fibrosis Patients.

scientific article published on 25 February 2015

Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.

scientific article published on February 2004

CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

scientific article published on May 2004

Capsule type of Streptococcus pneumoniae determines growth phenotype

scientific article

Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.

scientific article published on 16 September 2014

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection

scientific article (publication date: May 2015)

Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia.

scientific article published on 14 September 2017

Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults

scientific article published on April 2013

Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation.

scientific article published on 9 October 2017

Density and duration of experimental human pneumococcal carriage.

scientific article

Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells

scientific article

E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.

scientific article published on 7 February 2018

Erratum for Cornick et al., "Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus 32.2 Outbreak"

scientific article published in September 2018

Erratum for Graham-Brown et al., "Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation".

scientific article published on 22 May 2018

Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa.

scientific article published on 6 July 2018

Experimental human pneumococcal carriage.

scientific article published on 15 February 2013

Gene expression in fungi.

scientific article published on 13 May 2011

Host Cellular Immune Response to Pneumococcal Lung Infection in Mice.

scientific article published in April 2000

Host cellular immune response to pneumococcal lung infection in mice.

scientific article

Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.

scientific article published on 15 April 2005

Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations ⬇️

scientific article published on July 1, 2013

Increased TNF expression in CD43++ murine blood monocytes

scientific article published on 22 April 2008

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

scientific article published on 20 April 2020

Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes

scientific article published on 08 December 2020

Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae

scientific article

Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa.

scientific article

Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B

scientific article published on 20 December 2012

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux

scientific article

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections

scientific article published on 4 January 2017

Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses

scientific article published on 16 May 2012

P4-mediated antibody therapy in an acute model of invasive pneumococcal disease.

scientific article

Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14

scientific article

Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality

scientific article published on 11 January 2012

Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.

scientific article published on 6 March 2017

Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.

scientific article

Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae.

scientific article published in August 2012

Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.

scientific article

Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis.

scientific article published in February 2010

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

scientific article

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

scientific article published on 12 November 2018

Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi ⬇️

scientific article published on 12 July 2017

Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae.

scientific article published on April 2004

Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs

scientific article published on 2 September 2014

Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule

scientific article published on 27 September 2016

Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

scientific article published on 14 November 2016

Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains

scientific article

Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

scientific article

Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae.

scientific article

Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin

scientific article

Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice.

scientific article published on 21 October 2011

Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.

scientific article published in May 2009

Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges

scientific article published in 2022

Streptococcus pneumoniae detects and responds to foreign bacterial peptide fragments in its environment

scientific article

Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation.

scientific article

T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice

scientific article (publication date: 2012)

The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae

scientific article

The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae

scientific article published on 05 December 2007

The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation.

scientific article published on 26 April 2017

The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.

scientific article

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

scientific article published on 09 January 2017

The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.

scientific article

The innate immune response to pneumococcal lung infection: the untold story.

scientific article published on March 2004

The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection

scientific article published on 01 April 2011

The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract

scientific article

The role of pneumolysin in pneumococcal pneumonia and meningitis

scientific article

The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia

scientific article

Understanding pneumococcal serotype 1 biology through population genomic analysis

scientific article published on 8 November 2016

Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.

scientific article

List of works by Aras Kadioglu

A Subtype of a Pseudomonas aeruginosa Cystic Fibrosis Epidemic Strain Exhibits Enhanced Virulence in a Murine Model of Acute Respiratory Infection

A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia

Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections

Adhesion of rheumatoid peripheral blood and synovial fluid mononuclear cells to high endothelial venules of gut mucosa ⬇️

Airborne dust and high temperatures are risk factors for invasive bacterial disease.

Alternatives to antibiotics—a pipeline portfolio review

Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis.

Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse Pseudomonas aeruginosa from Cystic Fibrosis Patients.

Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.

CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

Capsule type of Streptococcus pneumoniae determines growth phenotype

Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection

Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia.

Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults

Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation.

Density and duration of experimental human pneumococcal carriage.

Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells

E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.

Erratum for Cornick et al., "Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus 32.2 Outbreak"

Erratum for Graham-Brown et al., "Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation".

Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa.

Experimental human pneumococcal carriage.

Gene expression in fungi.

Host Cellular Immune Response to Pneumococcal Lung Infection in Mice.

Host cellular immune response to pneumococcal lung infection in mice.

Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.

Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations ⬇️

Increased TNF expression in CD43++ murine blood monocytes

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes

Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae

Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa.

Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections

Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses

P4-mediated antibody therapy in an acute model of invasive pneumococcal disease.

Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14

Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality

Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.

Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.

Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae.

Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.

Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis.

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi ⬇️

Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae.

Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs

Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule

Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains

Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae.

Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin

Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice.

Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.

Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges

Streptococcus pneumoniae detects and responds to foreign bacterial peptide fragments in its environment

Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation.

T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice

The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae

The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae

The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation.

The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.

The innate immune response to pneumococcal lung infection: the untold story.

The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection

The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract

The role of pneumolysin in pneumococcal pneumonia and meningitis

The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia

Understanding pneumococcal serotype 1 biology through population genomic analysis

Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.