List of works - Chao Zhang

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

scientific article

A global representation of the protein fold space

scientific article

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

scientific article

Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

scientific article

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397

scientific article published on 6 April 2015

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

scientific article

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor ⬇️

scientific article published on March 14, 2013

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

scientific article

Fold prediction of helical proteins using torsion angle dynamics and predicted restraints

scientific article

Global mapping of the protein structure space and application in structure-based inference of protein function.

scientific article

KRAS insertion mutations are oncogenic and exhibit distinct functional properties

scientific article published on 8 February 2016

Overview of structural genomics: from structure to function

scientific article

Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma ⬇️

scientific article published on August 1, 2010

RAF inhibitors that evade paradoxical MAPK pathway activation

scientific article

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

scientific article published on January 2012

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

scientific article

Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase

scientific article

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

scientific article

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.

scientific article

Vemurafenib: the first drug approved for BRAF-mutant cancer ⬇️

scientific article published on October 12, 2012

List of works by Chao Zhang

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

A global representation of the protein fold space

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor ⬇️

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Fold prediction of helical proteins using torsion angle dynamics and predicted restraints

Global mapping of the protein structure space and application in structure-based inference of protein function.

KRAS insertion mutations are oncogenic and exhibit distinct functional properties

Overview of structural genomics: from structure to function

Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma ⬇️

RAF inhibitors that evade paradoxical MAPK pathway activation

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.

Vemurafenib: the first drug approved for BRAF-mutant cancer ⬇️