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List of works by Janet Rossant

2018 ISSCR Strategic Planning: Looking to the Future

scientific article published on 01 June 2019

A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia

scientific article

A Mouse for All Reasons

scientific article

A developmental journey and lessons learned along the way.

scientific article

A monoclonal mouse?

scientific article published on 01 February 2002

A new partner for the international knockout mouse consortium

scientific article published on 01 April 2007

A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis

scientific article

A novel Phex mutation in a new mouse model of hypophosphatemic rickets

scientific article published in July 2012

A novel in vitro model of trophoblast-mediated decidual blood vessel remodeling

scientific article published in December 2003

A public gene trap resource for mouse functional genomics

scientific article published on June 2004

A trusted voice for stem cell research.

scientific article

AIRE is a critical spindle-associated protein in embryonic stem cells

scientific article published on 25 July 2017

Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans.

scientific article published on 5 February 2015

Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1-deficient vascular progenitor cells

scientific article published on 2 October 2003

Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency

scientific article published on 01 May 2007

Alternative induced pluripotent stem cell characterization criteria for in vitro applications

scientific article published on 01 March 2009

An interview with Janet Rossant. Interview by Catarina Vicente

scientific article

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Anthony James Pawson (1952-2013).

scientific article

BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm

scientific article

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry

scientific article

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

scientific journal article

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

scientific article published on March 2009

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

scientific article

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis

scientific article published on 5 May 2008

Canada Gairdner Awards 2020: A Tightly Woven Tapestry of Discovery

scientific article published on 29 March 2020

Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. ⬇️

scientific article

Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo

scientific article

Cdx2 is essential for axial elongation in mouse development

scientific article

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

scientific journal article

Cell and molecular regulation of the mouse blastocyst

scientific article published on September 2006

Cell fate decisions in early blood vessel formation

scientific article

Cell lineage-specific undermethylation of mouse repetitive DNA

scientific article published in Nature

Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells

scientific article published on 15 March 2012

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

scientific article

Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling

scientific journal article

Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse

scientific journal article

Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology

scientific article published on 16 June 2009

Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells

scientific article

Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development.

scientific article

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin ⬇️

scientific article published on November 7, 2003

Conversion of human and mouse fibroblasts into lung-like epithelial cells

scientific article published on 21 June 2019

Corrigendum: Hallmarks of pluripotency

correction of a scholarly article

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes

scholarly article

Culturing Trophoblast Stem (TS) Cell Lines

scientific article published on 01 July 2006

Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens ⬇️

scientific article

Debate ethics of embryo models from stem cells

scientific article published on 01 December 2018

Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors

scientific article published on 15 September 2005

Depending on maternal Yap

scientific article

Derivation of Trophoblast Stem (TS) Cell Lines from Blastocysts

scientific article published on 01 July 2006

Developmental biology: A mouse is not a cow.

scientific article published in March 2011

Developmental differences in the expression of FGF receptors between human and mouse embryos

scientific article

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

scientific article published on September 2012

Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin

scientific article published on 8 September 2010

Disruption of early proximodistal patterning and AVE formation in Apc mutants

scientific journal article

Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos

scientific journal article

Distinct functions of BMP4 during different stages of mouse ES cell neural commitment

scientific article published on 26 May 2010

Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo

scientific article

Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells

scientific article published on 3 June 2016

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

scientific article (publication date: 15 February 2007)

Dosage-sensitive requirement for mouse Dll4 in artery development

scientific journal article

Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst

scientific article published on 12 November 2007

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice

scientific article (publication date: 2013)

Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway

scientific article published on 01 May 2006

Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling

scientific article published on 19 May 2015

Efficient Generation of Large-Fragment Knock-In Mouse Models Using 2-Cell (2C)-Homologous Recombination (HR)-CRISPR

scientific article published on 01 March 2020

Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.

scientific article published on 5 February 2015

Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos

scientific article

Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos

scientific article published on 11 June 2018

Emerging asymmetry and embryonic patterning in early mouse development

scientific article published in August 2004

Endothelial cells and VEGF in vascular development

scientific article

Engineering the embryo ⬇️

scientific article published on April 28, 2011

Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele

scientific article

Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos

scientific article published on 14 July 2019

Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells

scientific article

Ethics. The ISSCR guidelines for human embryonic stem cell research

scientific article published on February 2007

Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development

scientific article published on 15 February 2006

Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage

scientific article published in March 2003

Exploring early human embryo development

scientific article published on 01 June 2018

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

scientific article published in July 2001

FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst

scientific article

FGF signaling through FGFR1 is required for olfactory bulb morphogenesis

scientific article published in March 2003

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals

scientific journal article

Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice

scientific article

First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome

scientific article

Flt1/VEGFR1 heterozygosity causes transient embryonic edema

scientific article published on 02 June 2016

Foxh1 is essential for development of the anterior heart field

scientific journal article

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.

scientific article published on February 2010

Gene editing in human development: ethical concerns and practical applications

scientific article published on 25 July 2018

Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity

scientific article published on December 2002

Gene trapping in embryonic stem cells

scientific article

Gene-trap expression screening to identify endothelial-specific genes

scientific article published on 15 April 2004

Generation of Lung Epithelium from Pluripotent Stem Cells ⬇️

scientific article published on April 3, 2013

Genes for regeneration

scientific article published on 15 April 2014

Genetic Control of Early Cell Lineages in the Mammalian Embryo

scientific article published on 05 September 2018

Genetics: a balancing act.

scientific article published in September 2003

Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs

scientific article published on 28 August 2005

Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo

scientific article

Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling

scientific journal article

Gut endoderm takes flight from the wings of mesoderm

scientific article published in December 2014

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.

scientific article published on 28 March 2014

Hallmarks of pluripotency

scientific article published on September 2015

Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms

scientific article published on 25 March 2010

Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state

scientific article

High resolution ultrasound-guided microinjection for interventional studies of early embryonic and placental development in vivo in mice

scientific article

How signaling promotes stem cell survival: trophoblast stem cells and Shp2.

scientific article published in March 2006

Human ES cell lines—introduction

scientific article published on 07 March 2010

Human Embryo Editing: Opportunities and Importance of Transnational Cooperation

scientific article published in October 2017

Human embryology: Implantation barrier overcome

scientific article published on 4 May 2016

Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene

scientific article

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

scientific article published on 07 September 2016

Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential.

scientific article

Implementing large-scale ENU mutagenesis screens in North America

scientific article

Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts

scientific article published on 01 April 2005

Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast

scientific article published on 18 July 2019

Innovation as the core strategy for the future success of academic health centres ⬇️

scientific article published on June 1, 2011

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord

scientific article

Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes

scientific article published on 08 May 2007

Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation

scientific journal article

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

scientific journal article

Isolation and Maintenance of Trophoblast Stem Cells

Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency

scientific article

Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs

scientific article published in November 2008

Lineage allocation and asymmetries in the early mouse embryo

Lineage development and polar asymmetries in the peri-implantation mouse blastocyst

scientific article published in October 2004

Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms

scientific article published in December 2007

Location of transient ectodermal progenitor potential in mouse development

scientific article published on 16 October 2013

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

scientific article

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis

scientific article

Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos

scientific article published on 31 January 2008

Magnetic resonance imaging for detection and analysis of mouse phenotypes

scientific article

Making a knockout mouse: From stem cells to embryos

scientific article

Making the Mouse Blastocyst: Past, Present, and Future

scientific article published on 12 February 2016

Making the blastocyst: lessons from the mouse

scientific article

Mechanisms of pluripotency in vivo and in vitro

scientific article

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives

scientific article

Modeling pulmonary alveolar proteinosis with induced pluripotent stem cells

Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions

scientific article

Molecular determinants of lung development

scientific article published on April 2013

Molecular profiling of non-small cell lung cancer and correlation with disease-free survival

scientific article published on 01 June 2002

Mouse and human blastocyst-derived stem cells: vive les differences

scientific article

Mouse embryonic chimeras: tools for studying mammalian development ⬇️

scientific article published on December 1, 2003

Mouse trophoblast stem cells.

scientific article published in January 2006

Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis

scientific article published on 16 March 2016

NOBEL 2012 Physiology or medicine: Mature cells can be rejuvenated

scientific article published in December 2012

New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation

scientific article published on January 2017

New roles for model genetic organisms in understanding and treating human disease: report from the 2006 Genetics Society of America meeting

scientific article

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

scientific article

Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst

scientific article

PRISM, a generic large scale proteomic investigation strategy for mammals

scientific article published on 10 February 2003

Phenotypic annotation of the mouse X chromosome

scientific article

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

scientific article

Porcn-dependent Wnt signaling is not required prior to mouse gastrulation

scientific article

Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos

scientific article published on 30 April 2011

Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility

scientific article

Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs

scientific article

Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

scientific article published on 22 February 2017

Preparation of Polymerase Chain Reaction Templates from Embryonic and Adult Mouse Tissue Samples

scientific article published on 01 March 2019

Profile of Janet Rossant. Interview by Kristie Nybo

scientific article published in September 2012

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells

scientific article

Regulation of Porcupine-dependent Wnt signaling is essential for uterine development and fertility

scientific article published on 24 October 2017

Remembering Rosa Beddington--a tribute from her friends and colleagues

scientific article

Reprogramming to pluripotency: from frogs to stem cells

scientific article published in September 2009

Retinoic acid signaling regulates murine bronchial tubule formation

scientific article published in June 2003

Retinoid signaling determines germ cell fate in mice

scientific journal article

Retrospective. Anne McLaren (1927-2007)

scientific article (publication date: 3 August 2007)

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

scientific article

Signaling pathways in vascular development

scientific article

Sox17-mediated XEN cell conversion identifies dynamic networks controlling cell-fate decisions in embryo-derived stem cells

scientific article

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

scientific journal article

Stem Cells in Extraembryonic Lineages

Stem Cells in Extraembryonic Lineages

Stem Cells in Extraembryonic Lineages

Stem cells and early lineage development

scientific article

Stem cells and interspecies chimaeras

scientific article published on December 2016

Stem cells and lineage development in the mammalian blastocyst

scientific article published on January 2007

Stem cells assessed

scientific article published on 8 June 2012

Stem cells. Setting standards for human embryonic stem cells

scientific article

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

scientific article published on 01 June 2014

Studies on determination and differentiation in the early mammalian embryo

doctoral thesis

Targeting mammalian genes--rats join in and mice move ahead

scientific article published in June 2003

Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos

scientific article

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

scientific article published on 20 April 2018

The Centre for Modeling Human Disease Gene Trap resource

scientific article

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway

scientific article published in December 2010

The Hippo pathway member Nf2 is required for inner cell mass specification

scientific article

The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass

scientific journal article

The Impact of Developmental Biology on Pluripotent Stem Cell Research: Successes and Challenges ⬇️

scientific article published on July 19, 2011

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse

scientific article

The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research

scientific article published on July 2005

The Sweet Pee model for Sglt2 mutation

scientific article

The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice

scientific article published in July 2011

The challenge of regulating rapidly changing science: stem cell legislation in Canada

scientific article

The functional landscape of mouse gene expression

scientific article

The genetics of induced pluripotency

scientific article published on January 2010

The magic brew

scientific article published in Nature

The mammalian blastocyst

scientific article

The mammalian gene function resource: the International Knockout Mouse Consortium

scientific article

The mouse embryo autonomously acquires anterior-posterior polarity at implantation

scientific article published on April 2006

The mouse genome sequence--the end of the tail, or just the beginning?

scientific article

The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation

scientific journal article

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation

scientific article published on 7 December 2017

The role of FGF/Erk signaling in pluripotent cells

scientific article

The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome

scientific journal article

Three-dimensional analysis of vascular development in the mouse embryo

scientific article

Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells

scientific article published on 16 January 2020

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

scientific article published on 25 October 2011

Transcriptome analysis of mouse stem cells and early embryos

scientific article

Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype

scientific article published on 7 April 2003

Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia

scientific article published on 10 October 2011

Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta

scientific article

Trophoblast-specific gene manipulation using lentivirus-based vectors

scientific article published in March 2007

Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia

scientific article published on 01 May 2005

Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia

scientific article published in May 2005

Vascular Endothelial Growth Factor Directly Inhibits Primitive Neural Stem Cell Survival But Promotes Definitive Neural Stem Cell Survival

scientific article published on 01 June 2006

Vascular development and patterning: making the right choices

scientific article

Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival

scientific article published on 25 January 2006

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

scientific article published on February 2016

Zfp206 regulates ES cell gene expression and differentiation

scientific journal article

Zygotic Porcn paternal allele deletion in mice to model human focal dermal hypoplasia

scientific article

iPS cells: mapping the policy issues

scientific article published on December 2009

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