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List of works by Clemens Krepler

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

scientific article published in November 2017

A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers

scientific article published on 12 January 2017

Acetylsalicylic Acid Governs the Effect of Sorafenib in RAS- Mutant Cancers

scientific article

An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling

scientific article published on 28 July 2016

An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.

scientific article

Antitumor effect of G3139 Bcl-2 antisense oligonucleotide is independent of its immune stimulation by CpG motifs in SCID mice

scientific article published on December 2002

BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth

scientific article

Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma

scientific article published on 12 April 2018

Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma

scientific article published on 19 September 2013

Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

scientific article published on 21 February 2018

CpG oligonucleotides elicit antitumor responses in a human melanoma NOD/SCID xenotransplantation model

scientific article published in February 2004

Enhancing the evaluation of PI3K inhibitors through 3D melanoma models

scientific article

Functional profiling of live melanoma samples using a novel automated platform

scientific article

GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation

scientific article published on 19 July 2012

Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines

scientific article published in November 2017

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

scientific article published on 16 March 2016

Highlights of melanoma research presented at the 48th annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, IL, June 1–5, 2012 ⬇️

scientific article published on April 16, 2013

Highlights of melanoma research presented at the 49th annual meeting of the American Society of Clinical Oncology in Chicago, 2013.

scientific article

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

scientific article published on 21 March 2018

Meeting report from the 10th International Congress of the Society for Melanoma Research, Philadelphia, PA, November 2013.

scientific article published on 6 May 2014

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence

scientific article published in December 2017

Oncogenic BRAF-Mediated Melanoma Cell Invasion

scientific article published on 18 May 2016

PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

scientific article published on 27 September 2017

PIM kinases as therapeutic targets against advanced melanoma

scientific article published on 19 July 2016

Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies

scientific article published on 16 December 2015

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

scientific article published on 7 June 2017

Reduction of human melanoma tumor growth in severe combined immunodeficient mice by passive transfer of antibodies induced by a high molecular weight melanoma-associated antigen mimotope vaccine

scientific article

Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma

scientific article published on 16 September 2016

Targeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma

scientific article published on 13 June 2016

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

scientific article published on 4 April 2016

Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models

scientific article published on 19 December 2016

The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling

scientific article published in 2013

The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

scientific article published on 12 February 2013

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

scientific article published on 19 September 2017

miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment

scientific article

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