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List of works by Keiran S M Smalley

A brief history of melanoma: from mummies to mutations

scientific article

A database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancer

scientific article

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

scientific article

A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature

scientific article

Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma ⬇️

scientific article published on May 25, 2011

Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition

scientific article

Adhesion, migration and communication in melanocytes and melanoma

scientific article

Amuvatinib has cytotoxic effects against NRAS-mutant melanoma but not BRAF-mutant melanoma

scientific article

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

scientific article published in January 2007

An unholy alliance: cooperation between BRAF and NF1 in melanoma development and BRAF inhibitor resistance

scientific article published on March 2013

BRAF Inhibition Generates a Host-Tumor Niche that Mediates Therapeutic Escape

scientific article

BRAF inhibition for advanced locoregional BRAF V600E mutant melanoma: a potential neoadjuvant strategy

scientific article published on February 2016

BRAF inhibitors amplify the pro-apoptotic activity of MEK inhibitors by inducing ER stress in NRAS-mutant melanoma

scientific article published on 19 July 2017

BRAF-MEK inhibition in melanoma brain metastases: a new hope

scientific article

Beyond BRAF: where next for melanoma therapy?

scientific article

Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway

scientific article

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

scientific article

Ceritinib Enhances the Efficacy of Trametinib in BRAF/NRAS-Wild-Type Melanoma Cell Lines

scientific article published on 13 November 2017

Change or die: targeting adaptive signaling to kinase inhibition in cancer cells

scientific article

Combination Therapies for Melanoma: A New Standard of Care?

scientific article published on 10 February 2016

Combined BRAF and HSP90 Inhibition in Patients with Unresectable -Mutant Melanoma

Conjunctival melanomas harbor BRAF and NRAS mutations--Letter

scientific article published on 28 October 2013

Dabrafenib inhibits the growth of BRAF-WT cancers through CDK16 and NEK9 inhibition

scientific article published on 7 November 2017

Decitabine limits escape from MEK inhibition in uveal melanoma

scientific article published on 23 November 2019

Defining the conditions for the generation of melanocytes from human embryonic stem cells

scientific article published on 30 March 2006

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

scientific article

Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment

scientific article

Differentiation of human melanoma cells through p38 MAP kinase is associated with decreased retinoblastoma protein phosphorylation and cell cycle arrest.

scientific article

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

scientific article

Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells

scientific article published on February 2007

ERK Inhibition: A New Front in the War against MAPK Pathway-Driven Cancers?

scientific article published in February 2018

Evaluating kinase ATP uptake and tyrosine phosphorylation using multiplexed quantification of chemically labeled and post-translationally modified peptides.

scientific article published on 14 March 2015

Evaluating melanoma drug response and therapeutic escape with quantitative proteomics

scientific article

Experimental Treatments for Leptomeningeal Metastases From Solid Malignancies

scientific article

Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects

scientific article published on April 2002

Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells

scientific article published on June 2003

Feeling energetic? New strategies to prevent metabolic reprogramming in melanoma

scientific article published on 23 May 2015

Fibroblast-mediated drug resistance in cancer

scientific article published on 29 January 2013

Fibroblasts contribute to melanoma tumor growth and drug resistance.

scientific article published on 8 November 2011

Fibroblasts protect melanoma cells from the cytotoxic effects of doxorubicin.

scientific article

Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells.

scientific article

Frontiers in pigment cell and melanoma research

scientific article published on 03 October 2018

GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation

scientific article published on 19 July 2012

Genetic subgrouping of melanoma reveals new opportunities for targeted therapy

scientific article published on 07 April 2009

Get with the Program! Stemness and Reprogramming in Melanoma Metastasis

scientific article published in January 2018

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Identification of BRAF mutations in eruptive melanocytic nevi: new insights into melanomagenesis?

scientific article

Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression

scientific article published on July 2008

Improved survival of patients with melanoma brain metastases in the era of targeted BRAF and immune checkpoint therapies.

scientific article published on 12 October 2017

Improving patient outcomes to targeted therapies in melanoma

scientific article published on 3 May 2016

In vitro three-dimensional tumor microenvironment models for anticancer drug discovery.

scientific article published on January 2008

In vivo and in silico pharmacokinetics and biodistribution of a melanocortin receptor 1 targeted agent in preclinical models of melanoma

scientific article published on 08 July 2013

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

scientific article published on September 2008

Increased immunity and BRAF inhibition: Yet another argument for combination therapy?

scientific article

Inhibition of BRAF and BRAF+MEK drives a metastatic switch in melanoma

scientific article published on 19 March 2015

Inhibition of BRAF and MEK in BRAF-mutant melanoma

scientific article published on 31 May 2015

Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma models

scientific article

Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma

scientific article published on 28 March 2013

Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma.

scientific article published on 21 February 2014

Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells.

scientific article published on 14 February 2017

Integrating BRAF/MEK inhibitors into combination therapy for melanoma.

scientific article published on 20 January 2009

Integrating tumor-initiating cells into the paradigm for melanoma targeted therapy

scientific article published on March 2009

Introducing a checklist for manuscript submission to Pharmacological Research

scientific article published on 30 October 2015

Introduction to the Biochemical Pharmacology special issue on targeted cancer therapy

scientific article published on 6 March 2010

Ipilimumab.

scientific article

Is ERK activation a good biomarker for estradiol and tamoxifen effects?

scientific article published on 01 January 2007

Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.

scientific article published on 23 January 2007

Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions

scientific article published on 08 January 2020

Life isn't flat: taking cancer biology to the next dimension

scientific article published on September 2006

Ligand internalization and recycling by human recombinant somatostatin type 4 (h sst(4)) receptors expressed in CHO-K1 cells

scientific article

Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype

scientific article

Loitering with intent: new evidence for the role of BRAF mutations in the proliferation of melanocytic lesions

scientific article published in October 2004

Long-term effects of BRAF inhibitors in melanoma treatment: friend or foe?

scientific article

Making sense of MEK1 mutations in intrinsic and acquired BRAF inhibitor resistance

scientific article published in May 2012

Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy

scientific article

Measurement of constitutive MAPK and PI3K/AKT signaling activity in human cancer cell lines

scientific article published on January 2010

Meeting report from the 2011 International Melanoma Congress, Tampa, Florida

scientific article published on 9 December 2011

Melanoma biomarkers: current status and utility in diagnosis, prognosis, and response to therapy

scientific article published on January 2009

Melanoma genotypes and phenotypes get personal ⬇️

scientific article published on July 1, 2013

Melanoma--an unlikely poster child for personalized cancer therapy.

scientific article

Methods for investigation of targeted kinase inhibitor therapy using chemical proteomics and phosphorylation profiling.

scientific article

Molecular pathways: targeting NRAS in melanoma and acute myelogenous leukemia

scientific article

Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

scientific article

Mutant BRAF: A Novel Mediator of Microenvironmental Escape in Melanoma? ⬇️

scientific article published on May 1, 2013

NRAS mutant melanoma: biological behavior and future strategies for therapeutic management ⬇️

scientific article published on October 15, 2012

Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression

scientific article published on April 2006

Novel treatments for melanoma brain metastases

scientific article published on October 2013

Overcoming melanoma drug resistance through metabolic targeting?

scientific article

PLX-4032, a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.

scientific article published on June 2010

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

scientific article published on December 2010

PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

scientific article

Paradoxical oncogenesis--the long-term effects of BRAF inhibition in melanoma

scientific article published on 28 May 2013

Pharmacological research and precision cancer medicine: A call for manuscripts

scientific article published on 02 November 2015

Phase i trials in melanoma: A framework to translate preclinical findings to the clinic

scientific article published on 27 September 2016

Phosphoproteomic analysis of basal and therapy-induced adaptive signaling networks in BRAF and NRAS mutant melanoma

scientific article

Preclinical and clinical development of targeted therapy in melanoma: attention to schedule

scientific article published on 13 July 2009

Preface: National Cancer Act

scientific article published on 01 January 2012

Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy.

scientific article

Reply to Improving the survival of patients with American Joint Committee on Cancer stage III and IV melanoma.

scientific article published on 15 March 2018

Resistance mechanisms to genetic suppression of mutant NRAS in melanoma

scientific article

Resistance to Raf inhibition in cancer

scientific article

Rewired ERK-JNK signaling pathways in melanoma

scientific article

Selective evolutionary pressure from the tissue microenvironment drives tumor progression

scientific article

Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach

scientific article published on 30 September 2013

Similar Biological Activities of Two Isostructural Ruthenium and Osmium Complexes

scientific article

SinCHet: a MATLAB toolbox for single cell heterogeneity analysis in cancer

scientific article published on 4 May 2017

Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy

scientific article published in 2022

Space Is the Place: Mapping the Cell–Cell Interactions That Predict Immunotherapy Responses in Melanoma

scientific article published in 2022

Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity

scientific article

Taming the wild-types: targeting PAK1 in melanomas that lack BRAF mutations

scientific article published on 27 March 2013

Targeted therapy for melanoma: is double hitting a home run?

scientific article published on 4 December 2012

Targeted therapy in melanoma

scientific article published on 01 March 2013

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

scientific article published on 24 April 2015

Targeting intracellular signaling pathways as a novel strategy in melanoma therapeutics

scientific article

Targeting mutant BRAF and KIT in metastatic melanoma: ASCO 2009 meeting report.

scientific article

Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies

scientific article published in March 2012

Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells

scientific article published on 17 October 2016

Targeting the stromal fibroblasts: a novel approach to melanoma therapy

scientific article

The Blood Brain Barrier and BRAF inhibitors: Implications for patients with melanoma brain metastases

scientific article published on 13 November 2017

The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms

scientific article

The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression

scientific article published on 14 April 2015

The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma

scientific article

The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling

scientific article published in 2013

The biology and therapeutic management of melanoma brain metastases

scientific article

The complexity of microenvironment-mediated drug resistance

scientific article published on September 2015

The current state of targeted therapy in melanoma: this time it's personal

scientific article published in April 2012

The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis

scientific article

The future of targeted therapy approaches in melanoma.

scientific article published on April 2009

The great escape: another way for melanoma to leave physiological control?

scientific article published on October 2003

The involvement of p38 mitogen-activated protein kinase in the alpha-melanocyte stimulating hormone (alpha-MSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells

scientific article published on 01 July 2000

The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel

scientific article published in January 2008

The role of altered cell-cell communication in melanoma progression

scientific article published in March 2004

The role of phenotypic plasticity in the escape of cancer cells from targeted therapy.

scientific article published on 24 June 2016

The state of melanoma: challenges and opportunities

scientific article

The treatment of advanced renal cell cancer with high-dose oral thalidomide

scientific article

Understanding melanoma signaling networks as the basis for molecular targeted therapy

scientific article published on January 2010

Up close and personal: the challenges of precision medicine in melanoma

scientific article published on 01 February 2014

Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion

scientific article

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma

scientific article published on April 2011

Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells

scientific article published on 29 January 2013

Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma

scientific article published on September 2014

Why do women with melanoma do better than men?

scientific article published on 16 January 2018

XL888 Limits Vemurafenib-Induced Proliferative Skin Events by Suppressing Paradoxical MAPK Activation

scientific article published on 3 June 2015

c-KIT signaling as the driving oncogenic event in sub-groups of melanomas

scientific article published on May 2009

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