List of works - Hengming Ke

A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

scientific article

A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation

scientific article published on 17 September 2016

A Potential Substrate Binding Conformation of β-Lactams and Insight into the Broad Spectrum of NDM-1 Activity ⬇️

scientific article published on July 23, 2012

A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.

scientific article published in January 2017

Advances in targeting cyclic nucleotide phosphodiesterases

scientific article

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

scientific article

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

scientific article

Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors ⬇️

scientific article published on February 21, 2012

Computer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet Design

scientific article

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain ⬇️

scientific article published on September 21, 2010

Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

scientific article

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

scientific article

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

scientific article

Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding

scientific article

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

scientific article

Crystal structures of cyclophilin and its partners

scientific article published in September 2004

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

scientific article

Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity

scientific article published on January 2007

Crystallization of cyclic nucleotide phosphodiesterases

scientific article published in January 2005

Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E ⬇️

scientific article published on November 2, 2010

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

scientific article

Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors

scientific article published on December 2008

Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure

scientific article

Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure

scientific article

Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent

scientific article

Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate

scientific article

Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase

scientific article published on March 2006

Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability

scientific article published on 5 May 2006

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

scientific article

High-resolution design of a protein loop

scientific article

Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds

scientific article published on January 2011

Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis

scientific article

Is the cis-trans isomerization of cyclophilin involved in HIV-1 infectivity?

article

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡

scientific article

Molecular docking of competitive phosphodiesterase inhibitors

scientific article published in January 2002

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

scientific article

Phosphodiesterase Inhibitors as a New Generation of Antiprotozoan Drugs: Exploiting the Benefit of Enzymes that are Highly Conserved Between Host and Parasite ⬇️

scientific article published on August 1, 2011

Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain

scientific article published on 19 October 2008

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases ⬇️

scientific article published on February 3, 2012

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

scientific article published on 27 June 2012

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.

scientific article

Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine ⬇️

scientific article published on March 31, 2011

Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

scientific article

Structural Insight into the Substrate Specificity of Phosphodiesterases ⬇️

scientific article published on January 1, 2011

Structural insight into substrate specificity of phosphodiesterase 10

scientific article

Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design ⬇️

scientific article published on October 11, 2012

Structures of calcineurin and its complexes with immunophilins–immunosuppressants ⬇️

scientific article published on November 28, 2003

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding

scientific article

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

scientific article

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis, ⬇️

scientific article published on November 18, 2003

The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization

scientific article published on 25 March 2015

The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10

scientific article

Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases

scientific article published on January 2011

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

scientific article

[25] Overview of isomorphous replacement phasing.

scientific article published in January 1997

p53 Oligomerization is essential for its C-terminal lysine acetylation

scientific article

List of works by Hengming Ke

A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation

A Potential Substrate Binding Conformation of β-Lactams and Insight into the Broad Spectrum of NDM-1 Activity ⬇️

A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.

Advances in targeting cyclic nucleotide phosphodiesterases

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors ⬇️

Computer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet Design

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain ⬇️

Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

Crystal structures of cyclophilin and its partners

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity

Crystallization of cyclic nucleotide phosphodiesterases

Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E ⬇️

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors

Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure

Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure

Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent

Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate

Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase

Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

High-resolution design of a protein loop

Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds

Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis

Is the cis-trans isomerization of cyclophilin involved in HIV-1 infectivity?

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡

Molecular docking of competitive phosphodiesterase inhibitors

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

Phosphodiesterase Inhibitors as a New Generation of Antiprotozoan Drugs: Exploiting the Benefit of Enzymes that are Highly Conserved Between Host and Parasite ⬇️

Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases ⬇️

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.

Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine ⬇️

Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

Structural Insight into the Substrate Specificity of Phosphodiesterases ⬇️

Structural insight into substrate specificity of phosphodiesterase 10

Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design ⬇️

Structures of calcineurin and its complexes with immunophilins–immunosuppressants ⬇️

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis, ⬇️

The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization

The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10

Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

[25] Overview of isomorphous replacement phasing.

p53 Oligomerization is essential for its C-terminal lysine acetylation