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List of works by Gideon Bollag

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

scientific article

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

scientific article

An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling

scientific article published on 28 July 2016

An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling

scientific article

Anaphase-Promoting Complex Adaptor FZR1/CDH1 Blocks BRAF Signaling Both by Targeting BRAF for Proteolytic Degradation and by Disrupting BRAF Dimerization

scientific article published in April 2017

Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer ⬇️

scientific article published on December 16, 2011

BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor

scientific article published on 31 January 2018

Biochemical and functional characterization of germ line KRAS mutations

scientific article published on 17 September 2007

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer ⬇️

scientific article published on February 15, 2013

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397

scientific article published on 6 April 2015

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

scientific article

Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma

scientific article published on 10 December 2015

Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2.

scientific article

Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells

scientific article published in December 2009

Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells

scientific article

Deregulated Ras signaling in developmental disorders: new tricks for an old dog.

scientific article published on February 2007

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor ⬇️

scientific article published on March 14, 2013

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

scientific article

Drug discovery: Pocket of opportunity

scientific article published on 20 November 2013

GTPase activating proteins: critical regulators of intracellular signaling

scientific article

Germline KRAS mutations cause Noonan syndrome

scientific article

Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders

scientific article

Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy

scientific article

Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer

scholarly article by Wei Guan et al published 1 January 2019 in Endocrine-related cancer

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

scientific article published on 5 May 2015

Interrogating the kinome ⬇️

scientific article published on November 8, 2011

KRAS Engages AGO2 to Enhance Cellular Transformation

scientific article published on 03 February 2016

KRAS insertion mutations are oncogenic and exhibit distinct functional properties

scientific article published on 8 February 2016

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition ⬇️

scientific article published on October 26, 2012

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation

scientific article published in May 2011

PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras

scientific article published on 3 December 2013

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

scientific article published on December 2010

Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma ⬇️

scientific article published on August 1, 2010

Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma

scientific article

Phosphodiesterase-4 as a potential drug target

scientific article

Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer

scientific article

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

scientific article published in January 2010

RAF inhibitors that evade paradoxical MAPK pathway activation

scientific article

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

scientific article published on January 2012

RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

scientific article published on 15 June 2010

Raf pathway inhibitors in oncology

scientific article published on December 2003

Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents ⬇️

scientific article published on December 18, 2012

Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation ⬇️

scientific article published on December 28, 2011

Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo

scientific article published on 13 November 2017

Scaffold-based design of kinase inhibitors for cancer therapy

scientific article

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

scientific article

Setting up a Kinase Discovery and Development Project ⬇️

scientific article published on January 1, 2012

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

scientific article published on 21 November 2011

Structural basis for the activity of drugs that inhibit phosphodiesterases

scientific article

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

scientific article

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner ⬇️

scientific article published on July 28, 2010

The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis ⬇️

scientific article published on July 29, 2011

The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma

scientific article

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

scientific article published on 18 August 2015

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

scholarly article

Vemurafenib: the first drug approved for BRAF-mutant cancer ⬇️

scientific article published on October 12, 2012

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