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List of works by Robin Franklin

A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System

scientific article published on 18 September 2018

A map of transcriptional heterogeneity and regulatory variation in human microglia

scientific article published on 03 June 2021

Abnormal myelinogenesis in the central nervous system of the VF mutant rat with recoverable tremor.

scientific article published in October 2012

Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis

scientific article published on 21 June 2008

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

scientific article (publication date: 24 August 2008)

Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system

scientific article

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination

scientific article published on 30 April 2019

Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination

scientific article

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression ⬇️

scientific article

Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury.

scientific article

Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model

scientific article

Auxetic nuclei in embryonic stem cells exiting pluripotency.

scientific article published on 20 April 2014

Axon loss in multiple sclerosis.

scientific article published in August 1998

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy

scientific article published on 23 August 2016

Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.

scientific article published in July 2006

CNS Remyelination and the Innate Immune System

scientific article

CNS axons retain their competence for myelination throughout life.

scientific article published in February 2004

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

scientific article

Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system.

scientific article published on January 2007

Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

scientific article published on 01 October 2006

Cell therapy for spinal cord injuries: what is really going on?

scientific article published on 10 January 2014

Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.

scientific article

Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy.

scientific article

Clinical implications of myelin regeneration in the central nervous system

scientific article published on 29 December 2017

Comparison of cell populations derived from canine olfactory bulb and olfactory mucosal cultures.

scientific article published on June 2006

Congenital unilateral absence of the corticospinal tract in a Siamese cat.

scientific article published in November 2007

Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells.

scientific article published in December 2007

Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system.

scientific article published in March 2006

Current status of myelin replacement therapies in multiple sclerosis.

scientific article published on January 2012

Debris clearance by microglia: an essential link between degeneration and regeneration.

scientific article published on 20 June 2008

Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration

scientific article published on 01 January 2015

Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.

scientific article published on 28 January 2011

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

scientific article

Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination

scientific article published on 26 July 2005

Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter.

scientific article published on January 1995

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

scientific article published on 08 March 2022

Distinctive patterns of PDGF-A, FGF-2, IGF-I, and TGF-beta1 gene expression during remyelination of experimentally-induced spinal cord demyelination.

scientific article

Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?

scientific article published on 10 April 2019

Do olfactory glia have advantages over Schwann cells for CNS repair? ⬇️

scientific article published on December 1, 1997

Do your glial cells make you clever?

scientific article published in March 2013

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

scientific journal article

Effects of pre- versus post-anaesthetic buprenorphine on propofol-anaesthetized rats.

scientific article published in September 2005

Efficient Remyelination Requires DNA Methylation

scientific article published on 30 March 2017

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.

scientific article published on 28 July 2011

Electric Signals Regulate the Directional Migration of Oligodendrocyte Progenitor Cells (OPCs) via β1 Integrin.

scientific article

FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures.

scientific article published on 6 March 2010

Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS.

scientific article published on 22 June 2006

Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions.

scientific article

Fibronectin aggregation in multiple sclerosis lesions impairs remyelination ⬇️

scientific article published on January 1, 2013

Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency

scientific article published on 15 March 2012

Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage

scientific article published on 13 April 2016

Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.

scientific article published in January 2011

Glia Disease and Repair-Remyelination

scientific article published on 18 May 2015

Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS

scientific article published on 01 February 1995

Hereditary ataxia, myokymia and neuromyotonia in Jack Russell terriers

scientific article published on 01 August 2012

High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.

scientific article published on 31 October 2013

Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS.

scientific article published in November 2004

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.

scientific article

Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination.

scientific article published on 21 October 2013

Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes

scientific article published on November 2010

Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells

scientific article published on 17 September 2018

Isolation and long-term expansion of functional, myelinating oligodendrocyte progenitor cells from neonatal rat brain.

scientific article

Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells

scientific article

LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination.

scientific article published on 14 August 2017

Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system ⬇️

scientific article published on October 15, 1997

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

scientific article

Macrophages and CNS remyelination

scientific article published on 26 March 2014

Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres.

scientific article published on 25 January 2006

Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.

scientific article

Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

scientific article published on 3 July 2012

Mechanisms of CNS remyelination--the key to therapeutic advances.

scientific article

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

scientific article published on 6 July 2014

Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination.

scientific article published in January 2005

Multiple sclerosis genetics

scientific article published on 19 May 2014

Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs

scientific article published on 08 December 2006

Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation

scientific article

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells

scientific article published on October 2011

Myelin regeneration: a recapitulation of development?

scientific article published on January 2011

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

scientific article

Myokymia and neuromyotonia in veterinary medicine: a comparison with peripheral nerve hyperexcitability syndrome in humans.

scientific article published on 11 April 2013

Nasal and frontal sinus mucosa of the adult dog contain numerous olfactory sensory neurons and ensheathing glia.

scientific article

Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes

scientific article

Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.

scientific article published on August 2008

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination ⬇️

scientific article published on December 12, 2011

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis

scientific article published on 23 December 2013

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

scientific article

Neuronal vulnerability and multilineage diversity in multiple sclerosis

scientific article published on 17 July 2019

Neuroprotection and repair in multiple sclerosis ⬇️

scientific article published on 02 October 2012

Neuroscience. The mysteries of myelin unwrapped.

scientific article

Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.

scientific article published on 2 August 2004

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

scientific article

Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS

scientific article published on 10 January 2006

Oligodendrocyte progenitors: adult stem cells of the central nervous system?

scientific article published on 05 May 2014

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

scientific article published on 11 September 2018

Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat ⬇️

scientific article published on March 9, 2011

Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination

scientific article published on 04 May 2008

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

scientific article published on August 2017

Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis.

scientific article

Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes.

scientific article

Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.

scientific article published in February 2004

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination.

scientific article published on 7 January 2016

Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: defining cellular targets.

scientific article published on 13 June 2007

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

scientific article (publication date: March 2009)

Reconstruction of the glia limitans by sub-arachnoid transplantation of astrocyte-enriched cultures

scientific article published on 01 November 1995

Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease.

scientific article published on 23 February 2017

Regenerating CNS myelin - from mechanisms to experimental medicines.

scientific article published in November 2017

Regenerative Medicines for Remyelination: From Aspiration to Reality

scientific article published on 01 June 2015

Regulatory T cells promote myelin regeneration in the central nervous system.

scientific article published on 13 March 2017

Rejuvenation of Regeneration in the Aging Central Nervous System ⬇️

scientific article published on January 6, 2012

Remyelination - An effective means of neuroprotection.

scientific article published on 16 June 2009

Remyelination by transplanted olfactory ensheathing cells.

scientific article

Remyelination: the true regeneration of the central nervous system.

scientific article published on 05 July 2013

Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells

scientific article published in Nature

Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins

scientific article published on 01 February 2004

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

scientific article

Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis

scientific article published on 01 April 2011

Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System.

scientific article

Schwann cell remyelination is restricted to astrocyte-deficient areas after transplantation into demyelinated adult rat brain

scientific article published on 01 June 2000

Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival.

scientific article published in August 2000

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

scientific article published on 21 November 2018

Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination.

scientific article published on August 2015

Special issue on stem cells: "the end of the beginning".

scientific article

Stem cell treatments and multiple sclerosis

scientific article published on 11 March 2010

Stem cells, progenitors and myelin repair.

scientific article

Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

scientific article published on 08 February 2017

Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS

scientific article published on 01 November 2004

The Brown Animal Sanatory Institution--historical lessons for the present?

scientific article

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury

scientific article

The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination

scientific article published on 25 August 2014

The VF rat with abnormal myelinogenesis has a mutation in Dopey1.

scientific article

The biology of CNS remyelination: the key to therapeutic advances.

scientific article published on March 2008

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination

scientific article published on 04 February 2020

The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

scientific article published on 02 July 2013

The phagocytic capacity of neurones

scientific article published on 01 May 2007

The translational biology of remyelination: past, present, and future

scientific article published on 20 January 2014

Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors

scientific article published on 12 March 2019

Type 1 astrocytes fail to inhibit Schwann cell remyelination of CNS axons in the absence of cells of the O-2A lineage.

scientific article published on January 1992

Tyrosine kinases: maiming myelin in leprosy

scientific article published on 01 August 2006

Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin

scientific article published on 07 December 2016

Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.

scientific article published in November 2009

Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

scientific article

What roles do growth factors play in CNS remyelination?

scientific article

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