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List of works by Doron Merkler

Aggravation of viral hepatitis by platelet-derived serotonin

scientific article published on 30 May 2008

B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.

scientific article published on 06 October 2016

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

scientific article published on 01 June 2019

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

scientific article published on 04 July 2016

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

scientific article published on 09 September 2019

Clival chordoma: a single-centre outcome analysis

scientific article

Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report.

scientific article

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior ⬇️

scientific article published on January 17, 2012

Enhanced Voluntary Exercise Improves Functional Recovery following Spinal Cord Injury by Impacting the Local Neuroglial Injury Response and Supporting the Rewiring of Supraspinal Circuits

scientific article published on 10 August 2018

Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

scientific article published on 17 March 2020

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.

scientific article

Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

scientific article published on 4 November 2007

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

scientific article published on 30 August 2018

Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours.

scientific article published on 14 August 2017

Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells

scientific article published on 11 August 2014

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner.

scientific article published on 7 March 2018

IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

scientific article published on 08 June 2022

IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system

scientific article

Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis

scientific article

In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology

scientific article published on 06 March 2016

Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients

scientific article published on 24 July 2017

Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers

scientific article

Interferon-driven deletion of antiviral B cells at the onset of chronic infection.

scientific article published on October 2016

Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever.

scientific article

Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

scientific article published in February 2012

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses.

scientific article published on 20 April 2016

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

scientific article published on 18 November 2007

Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue

scientific article published on January 2014

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

scientific article

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

scientific article published on 29 October 2018

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

scientific article published on 30 August 2018

Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE)

scientific article published on 01 January 2016

Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity

scientific article published on 10 November 2014

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

scientific article published on 05 May 2021

Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

scientific article published on 12 February 2021

Rapid induction of autoantibodies against Nogo‐A and MOG in the absence of an encephalitogenic T cell response: implication for immunotherapeutic approaches in neurological diseases ⬇️

scientific article published on October 16, 2003

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

scientific article

Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review

scientific article

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy.

scientific article

Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?

article

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells.

scientific article published on 24 November 2017

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

scientific article published on 01 April 2020

T cell-dependence of Lassa fever pathogenesis

scientific article

TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells

scientific article published on August 2016

Targeted ablation of oligodendrocytes triggers axonal damage

scientific article (publication date: 2011)

The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs.

scientific article published on 30 October 2017

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 T cells

scientific article published on 06 June 2018

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

scientific article published on 21 August 2012

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

scientific article published on 20 April 2015

[CORRECTION] High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

scientific article published in March 2018

pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion

scientific article published on 31 October 2016

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